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T2DM was\nrandomly divided into 5 groups: diabetic control mice treated with vehicle (model group, n=10), metformin-\ntreated group (metformin: 150 mg\/kg.d, n=10), three CS-treated groups (CS: 300, 600 and\n1200 mg\/kg.d, n=10). After four weeks of CS treatment, the body weight, FBG, IR, TC, TG, LDL-C,\nMDA and SOD levels of mice were measured. In addition, the liver tissue was histomorphologically\nanalyzed by HE stain followed a light microscopy observation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>4-week CSE treatment significantly reduced FBG and enhanced the glucose tolerance; improved\nIR indicated by decreased HOMA-IR and elevated ISI; alleviated hyperlipidemia indicated by\ndecreased TC, TG, LDL-C, and increased HDL-C; reduced oxidative stress by decreased MDA and\nelevated SOD activity; decreased hepatic lipid accumulation and prevented liver tissue morphological\nchange in T2DM. In addition, CSE treatments effectively prevent the weight gain loss of diabetic mice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>These results confirmed the traditionally claimed benefits of corn silk on DM, which\nsuggested that the corn silk possessed the anti-diabetic potential and could be further developed as a\ncheap and plant-derived agent for the treatment of type 2 diabetes mellitus.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200606224708","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T19:37:37Z","timestamp":1591472257000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of Anti-Diabetic Potential of Corn Silk in High-Fat Diet\/ Streptozotocin-Induced Type 2 Diabetes Mice Model"],"prefix":"10.2174","volume":"21","author":[{"given":"Li","family":"Sheng","sequence":"first","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Di","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-172X","authenticated-orcid":true,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/414782a","volume":"414","author":"Zimmet P.","year":"2001","unstructured":"Zimmet P.; Alberti K.G.; Shaw J.; Global and societal implications of the diabetes epidemic. 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