{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:02:50Z","timestamp":1776405770148,"version":"3.51.2"},"reference-count":37,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/100015807","name":"Hangzhou Municipal Commission of Health and Family Planning Science and Technology Program","doi-asserted-by":"publisher","award":["OO20190253"],"award-info":[{"award-number":["OO20190253"]}],"id":[{"id":"10.13039\/100015807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011493","name":"Scientific Research fund of Taizhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2018C320007"],"award-info":[{"award-number":["2018C320007"]}],"id":[{"id":"10.13039\/501100011493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2014KYB219"],"award-info":[{"award-number":["2014KYB219"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2017196976"],"award-info":[{"award-number":["2017196976"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004862","name":"Key Project of Zhejiang Province Science and Technology Plan","doi-asserted-by":"publisher","award":["2014C03048-1"],"award-info":[{"award-number":["2014C03048-1"]}],"id":[{"id":"10.13039\/501100004862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472861"],"award-info":[{"award-number":["81472861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Mixed medullary and follicular thyroid carcinoma (MMFC) displays heterogeneous\nmorphological components and immunophenotypical features intermingled within the same\nlesion, which is rare and most described in the sporadic form. We report herein a Chinese patient with\nmultiple endocrine neoplasia type 2B (MEN2B) harboring germline RET M918T and associated\nMMFC.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A case of a 39-year-old male patient with MEN2B presented palpable neck masses in both\nthyroid lobes (maximum sizes: left, 3.9 cm; right, 5.4 cm) and a definitive phenotype. Serum levels of\ncalcitonin (Ctn; &gt;2000pg\/mL), carcinoembryonic antigen (CEA; 719.27ng\/mL), and thyroglobulin\n(Tg; 98.54ng\/mL) were high. Fine-needle aspiration cytology showed features positive for malignancy,\nsuggesting the possibility of medullary thyroid carcinoma (MTC). Total thyroidectomy, along with\nextending bilateral neck lymph nodes dissection, and subsequently, genetics family screening were\nperformed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The histopathological examination yielded a diagnosis of MMFC that showed immunohistochemical\ncharacteristic patterns of the component of MTC positive for Ctn and CEA, chromogranin A,\nand the follicular carcinoma components were positive for Tg. Lymph node metastasis was observed\nshowing medullary tumoral cells positive for Ctn and follicular-like structures lacking tumor cells positive\nfor Tg staining (T4bN1bM0). Genetics screening confirmed RET M918T (c.2753T&gt;C) mutation\nmanifested in the patient but was not detected in other family members. Follow up showed that the\nserum Ctn, CEA and Tg levels respectively dropped to 54.38pg\/ml, 4.16ng\/mL and 0.04ng\/mL 16\nmonths after the surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Particular and diverse patterns of MMFC should be recognized with immunostaining\nfeatures. MMFC occurring in a patient with MEN2B harboring RET M918T may be unique biological\nbehavior and the treatment is mostly radical surgery.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200713092633","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T06:12:21Z","timestamp":1594707141000},"page":"554-560","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple Endocrine Neoplasia Type 2B Associated Mixed Medullary and Follicular Thyroid Carcinoma in A Chinese Patient with RET M918T Germline Mutation"],"prefix":"10.2174","volume":"21","author":[{"given":"Xiao-Ping","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, 40 Jichang Road, Hangzhou 310004, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Bing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, The Affiliated Wenling Hospital of Wenzhou Medical University, Chuan\u2019an Nan Road, Chengxi Subdistrict, Wenling 317500, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, No.1 East Banshan Road, Hangzhou 310022, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, 40 Jichang Road, Hangzhou 310004, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Lie","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, 40 Jichang Road, Hangzhou 310004, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Hui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, No.1 East Banshan Road, Hangzhou 310022, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Qiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, No.1 East Banshan Road, Hangzhou 310022, Zhejiang Province,China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1089\/thy.2014.0335","volume":"25","author":"Wells S.A.","year":"2015","unstructured":"Wells S.A.; Asa S.L.; Dralle H.; Elisei R.; Evans D.B.; Gagel R.F.; Lee N.; Machens A.; Moley J.F.; Pacini F.; Raue F.; Frank-Raue K.; Robinson B.; Rosenthal M.S.; Santoro M.; Schlumberger M.; Shah M.; Waguespack S.G.; American thyroid association guidelines task force on medullary thyroid carcinoma. Revised American thyroid association guidelines for the management of medullary thyroid carcinoma. Thyroid 2015,25(6),567-610","journal-title":"Thyroid"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000346174","volume":"1","author":"Elisei R.","year":"2013","unstructured":"Elisei R.; Alevizaki M.; Conte-Devolx B.; Frank-Raue K.; Leite V.; Williams G.R.; 2012 European thyroid association guidelines for genetic testing and its clinical consequences in medullary thyroid cancer. Eur Thyroid J 2013,1(4),216-231","journal-title":"Eur Thyroid J"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/SLA.0b013e3182a6f43a","volume":"259","author":"Brauckhoff M.","year":"2014","unstructured":"Brauckhoff M.; Machens A.; Lorenz K.; Bj\u00f8ro T.; Varhaug J.E.; Dralle H.; Surgical curability of medullary thyroid cancer in multiple endocrine neoplasia 2B: a changing perspective. Ann Surg 2014,259(4),800-806","journal-title":"Ann Surg"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1210\/jc.2017-01884","volume":"103","author":"Raue F.","year":"2018","unstructured":"Raue F.; Dralle H.; Machens A.; Bruckner T.; Frank-Raue K.; Long-term survivorship in multiple endocrine neoplasia type 2B diagnosed before and in the new millennium. J Clin Endocrinol Metab 2018,103(1),235-243","journal-title":"J Clin Endocrinol Metab"},{"key":"ref=5","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/571692","author":"Tohidi M.","year":"2013","unstructured":"Tohidi M.; Pourbehi G.; Bahmanyar M.; Eghbali S.S.; Kalantar Hormozi M.; Nabipour I.; Mixed medullary-follicular carcinoma of the thyroid. Case Rep Endocrinol 2013","journal-title":"Case Rep Endocrinol"},{"key":"ref=6","first-page":"488","volume":"90","author":"Ben Salah R.","year":"2012","unstructured":"Ben Salah R.; Mekni A.; Doghri R.; Kchir N.; Haouet S.; Besbes G.; Bouchoucha S.; Zitouna M.; A mixed medullary-follicular thyroid carcinoma discovered by fine needle aspiration. Tunis Med 2012,90(6),488-490","journal-title":"Tunis Med"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1002\/dc.21560","volume":"39","author":"Hanna A.N.","year":"2011","unstructured":"Hanna A.N.; Michael C.W.; Jing X.; Mixed medullary-follicular carcinoma of the thyroid: diagnostic dilemmas in fine-needle aspiration cytology. Diagn Cytopathol 2011,39(11),862-865","journal-title":"Diagn Cytopathol"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1089\/thy.2012.0134","volume":"22","author":"Qi X.P.","year":"2012","unstructured":"Qi X.P.; Chen X.L.; Ma J.M.; Du Z.F.; Fei J.; Yang C.P.; Cheng J.; Song Q.Z.; Han J.S.; Jin H.Y.; Chen Z.G.; Wang J.Q.; Yang Y.P.; Ying R.B.; Liu W.T.; Zhao Y.; Chen C.Y.; Jiang H.L.; Ke H.P.; Zhang X.N.; RET proto-oncogene genetic screening of families with multiple endocrine neoplasia type 2 optimizes diagnostic and clinical management in China. Thyroid 2012,22(12),1257-1265","journal-title":"Thyroid"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10689-011-9487-1","volume":"11","author":"Qi X.P.","year":"2012","unstructured":"Qi X.P.; Ying R.B.; Ma J.M.; Liu W.T.; Du Z.F.; Fei J.; Yang C.P.; Song Q.Z.; Jin H.Y.; Chen Z.G.; Han J.S.; Wang J.Q.; Chen X.L.; Zhao Y.; Lu J.J.; Zhang X.N.; Case report: a p.C618S RET proto-oncogene germline mutation in a large Chinese pedigree with familial medullary thyroid carcinoma. Fam Cancer 2012,11(1),131-136","journal-title":"Fam Cancer"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/S0002-9440(10)65465-X","volume":"155","author":"Volante M.","year":"1999","unstructured":"Volante M.; Papotti M.; Roth J.; Saremaslani P.; Speel E.J.; Lloyd R.V.; Carney J.A.; Heitz P.U.; Bussolati G.; Komminoth P.; Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components. Am J Pathol 1999,155(5),1499-1509","journal-title":"Am J Pathol"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1055\/s-0029-1241851","volume":"118","author":"Frank-Raue K.","year":"2010","unstructured":"Frank-Raue K.; D\u00f6hring J.; Scheumann G.; Rondot S.; Lorenz A.; Schulze E.; Dralle H.; Raue F.; Leidig-Bruckner G.; New mutations in the RET protooncogene-L881V - associated with medullary thyroid carcinoma and -R770Q - in a patient with mixed medullar\/follicular thyroid tumour. Exp Clin Endocrinol Diabetes 2010,118(8),550-553","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/BF03343809","volume":"24","author":"Orlandi F.","year":"2001","unstructured":"Orlandi F.; Chiefari E.; Caraci P.; Mussa A.; Gonzatto I.; De Giuli P.; Giuffrida D.; Angeli A.; Filetti S.; RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma. J Endocrinol Invest 2001,24(1),51-55","journal-title":"J Endocrinol Invest"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.2169\/internalmedicine.50.4749","volume":"50","author":"Ueki I.","year":"2011","unstructured":"Ueki I.; Ando T.; Haraguchi A.; Horie I.; Imaizumi M.; Hayashi T.; Uga T.; Usa T.; Kawakami A.; A case of mixed medullary and follicular cell carcinoma of the thyroid. Intern Med 2011,50(12),1313-1316","journal-title":"Intern Med"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1385\/EP:11:4:353","volume":"11","author":"Shimizu M.","year":"2000","unstructured":"Shimizu M.; Hirokawa M.; LiVolsi, V.A.; Mizukami, Y.; Harada, T.; Itoh, T.; Manabe, T. Combined \u201cmixed medullary-follicular\u201d and \u201cpapillary\u201d carcinoma of the thyroid with lymph node metastasis. Endocr Pathol 2000,11(4),353-358","journal-title":"Endocr Pathol"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4038\/cmj.v45i1.7955","volume":"45","author":"Hewavisenthi S.J.","year":"2000","unstructured":"Hewavisenthi S.J.; Ariyarathne J.; Gunawardena P.A.; Mixed medullary follicular carcinoma--an unusual thyroid neoplasm. Ceylon Med J 2000,45(1),34-35","journal-title":"Ceylon Med J"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000078576","volume":"61","author":"Kostoglou-Athanassiou I.","year":"2004","unstructured":"Kostoglou-Athanassiou I.; Athanassiou P.; Vecchini G.; Gogou L.; Kaldrymides P.; Mixed medullary-follicular thyroid carcinoma. Report of a case and review of the literature. Horm Res 2004,61(6),300-304","journal-title":"Horm Res"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/01.rlu.0000122802.64681.2d","volume":"29","author":"Bhatnagar P.","year":"2004","unstructured":"Bhatnagar P.; Bhatnagar A.; Kishan S.; Bal C.S.; Saran R.K.; Sinha S.; Kashyap R.; Unusual widespread metastatic presentation of mixed medullary-follicular thyroid carcinoma. Clin Nucl Med 2004,29(5),303-305","journal-title":"Clin Nucl Med"},{"key":"ref=18","first-page":"CS31","volume":"14","author":"Maruna P.","year":"2008","unstructured":"Maruna P.; Duskova J.; Limanova Z.; Dvorakov\u00e1 S.; Vaclavikova E.; Bendlova B.; Mixed medullary and follicular cell carcinoma of the thyroid in a 71-year-old man with history of malignant melanoma. Med Sci Monit 2008,14(4),CS31-CS36","journal-title":"Med Sci Monit"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/PAP.0b013e3181e4ab3e","volume":"17","author":"Sadow P.M.","year":"2010","unstructured":"Sadow P.M.; Hunt J.L.; Mixed Medullary-follicular-derived carcinomas of the thyroid gland. Adv Anat Pathol 2010,17(4),282-285","journal-title":"Adv Anat Pathol"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000325524","volume":"52","author":"Hsieh M.H.","year":"2008","unstructured":"Hsieh M.H.; Lin M.C.; Shun C.T.; Chang T.C.; Fine needle aspiration cytology of mixed medullary-follicular thyroid carcinoma: a case report. Acta Cytol 2008,52(3),361-365","journal-title":"Acta Cytol"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1385\/EP:13:1:75","volume":"13","author":"Cakir M.","year":"2002","unstructured":"Cakir M.; Altunbas H.; Balci M.K.; Karayalcin U.; Karpuzoglu G.; Medullary thyroid carcinoma, follicular variant. Endocr Pathol 2002,13(1),75-79","journal-title":"Endocr Pathol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000326478","volume":"47","author":"Duskov\u00e1 J.","year":"2003","unstructured":"Duskov\u00e1 J.; Janotov\u00e1 D.; Svobodov\u00e1 E.; Nov\u00e1k Z.; Tretin\u00edk P.; Fine needle aspiration biopsy of mixed medullary-follicular thyroid carcinoma. A report of two cases. Acta Cytol 2003,47(1),71-77","journal-title":"Acta Cytol"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1365-2559.1993.tb00123.x","volume":"22","author":"Mizukami Y.","year":"1993","unstructured":"Mizukami Y.; Michigishi T.; Nonomura A.; Nakamura S.; Noguchi M.; Hashimoto T.; Itoh N.; Mixed medullary-follicular carcinoma of the thyroid occurring in familial form. Histopathology 1993,22(3),284-287","journal-title":"Histopathology"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1002\/1097-0142(19940801)74:3<928:AID-CNCR2820740321>3.0.CO;2-E","volume":"74","author":"Kovacs C.S.","year":"1994","unstructured":"Kovacs C.S.; Mas\u00e9 R.M.; Kovacs K.; Nguyen G.K.; Chik C.L.; Thyroid medullary carcinoma with thyroglobulin immunoreactivity in sporadic multiple endocrine neoplasia type 2-B. Cancer 1994,74(3),928-932","journal-title":"Cancer"},{"key":"ref=25","first-page":"109","volume":"17","author":"Papotti M.","year":"2000","unstructured":"Papotti M.; Volante M.; Komminoth P.; Sobrinho-Sim\u00f5es M.; Bussolati G.; Thyroid carcinomas with mixed follicular and C-cell differentiation patterns. Semin Diagn Pathol 2000,17(2),109-119","journal-title":"Semin Diagn Pathol"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s004280050049","volume":"430","author":"Papotti M.","year":"1997","unstructured":"Papotti M.; Negro F.; Carney J.A.; Bussolati G.; Lloyd R.V.; Mixed medullary-follicular carcinoma of the thyroid. A morphological, immunohistochemical and in situ hybridization analysis of 11 cases. Virchows Arch 1997,430(5),397-405","journal-title":"Virchows Arch"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1089\/thy.1991.1.249","volume":"1","author":"Noel M.","year":"1991","unstructured":"Noel M.; Delehaye M.C.; Segond N.; Lasmoles F.; Caillou B.; Gardet P.; Fragu P.; Moukhtar M.S.; Study of calcitonin and thyroglobulin gene expression in human mixed follicular and medullary thyroid carcinoma. Thyroid 1991,1(3),249-256","journal-title":"Thyroid"},{"key":"ref=28","author":"Lloyd R.V.","year":"2017","unstructured":"Lloyd R.V.; Osamura R.Y.; Kl\u00f6ppel G.; Rosai J.;  WHO Classification of Tumours Pathology and Genetics of Tumours of Endocrine Organs 2017","journal-title":"WHO Classification of Tumours Pathology and Genetics of Tumours of Endocrine Organs"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1967\/s002449910137","volume":"17","author":"Erhamamci S.","year":"2014","unstructured":"Erhamamci S.; Reyhan M.; Kocer N.E.; Nursal G.N.; Torun N.; Yapar A.F.; Simultaneous occurrence of medullary and differentiated thyroid carcinomas. Report of 4 cases and brief review of the literature. Hell J Nucl Med 2014,17(2),148-152","journal-title":"Hell J Nucl Med"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0046-8177(89)90208-6","volume":"20","author":"Tanaka T.","year":"1989","unstructured":"Tanaka T.; Yoshimi N.; Kanai N.; Mori H.; Nagai K.; Fujii A.; Sakata S.; Tokimitsu N.; Simultaneous occurrence of medullary and follicular carcinoma in the same thyroid lobe. Hum Pathol 1989,20(1),83-86","journal-title":"Hum Pathol"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/hed.20984","volume":"31","author":"Nangue C.","year":"2009","unstructured":"Nangue C.; Bron L.; Portmann L.; Volante M.; Ris H.B.; Monnier P.; Andrejevic-Blant S.; Mixed medullary-papillary carcinoma of the thyroid: report of a case and review of the literature. Head Neck 2009,31(7),968-974","journal-title":"Head Neck"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1245\/s10434-012-2357-8","volume":"19","author":"Wong R.L.","year":"2012","unstructured":"Wong R.L.; Kazaure H.S.; Roman S.A.; Sosa J.A.; Simultaneous medullary and differentiated thyroid cancer: a population-level analysis of an increasingly common entity. Ann Surg Oncol 2012,19(8),2635-2642","journal-title":"Ann Surg Oncol"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/dc.23924","volume":"46","author":"Liu Y.","year":"2018","unstructured":"Liu Y.; Yuan L.; Yang D.; Jin Y.; Serum calcitonin negative mixed medullary-follicular carcinoma initially diagnosed as medullary thyroid carcinoma by fine-needle aspiration cytology: A case report and review of the literatures. Diagn Cytopathol 2018,46(8),690-693","journal-title":"Diagn Cytopathol"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1089\/thy.2016.0399","volume":"27","author":"Lebeault M.","year":"2017","unstructured":"Lebeault M.; Pinson S.; Guillaud-Bataille M.; Gimenez-Roqueplo A.P.; Carrie A.; Barbu V.; Pigny P.; Bezieau S.; Rey J.M.; Delvincourt C.; Giraud S.; Veyrat-Durebex C.; Saulnier P.; Bouzamondo N.; Chabbert M.; Blin J.; Mohamed A.; Romanet P.; Borson-Chazot F.; Rohmer V.; Barlier A.; Mirebeau-Prunier D.; Nationwide French study of RET variants detected from 2003 to 2013 suggests a possible influence of polymorphisms as modifiers. Thyroid 2017,27(12),1511-1522","journal-title":"Thyroid"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1210\/jc.2013-1204","volume":"98","author":"Wells S.A.","year":"2013","unstructured":"Wells S.A.; Pacini F.; Robinson B.G.; Santoro M.; Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update. J Clin Endocrinol Metab 2013,98(8),3149-3164","journal-title":"J Clin Endocrinol Metab"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S2213-8587(18)30336-X","volume":"7","author":"Castinetti F.","year":"2019","unstructured":"Castinetti F.; Waguespack S.G.; Machens A.; Uchino S.; Hasse-Lazar K.; Sanso G.; Else T.; Dvorakova S.; Qi X.P.; Elisei R.; Maia A.L.; Glod J.; Louren\u00e7o D.M.; Valdes N.; Mathiesen J.; Wohllk N.; Bandgar T.R.; Drui D.; Korbonits M.; Druce M.R.; Brain C.; Kurzawinski T.; Patocs A.; Bugalho M.J.; Lacroix A.; Caron P.; Fainstein-Day P.; Borson Chazot F.; Klein M.; Links T.P.; Letizia C.; Fugazzola L.; Chabre O.; Canu L.; Cohen R.; Tabarin A.; Spehar Uroic A.; Maiter D.; Laboureau S.; Mian C.; Peczkowska M.; Sebag F.; Brue T.; Mirebeau-Prunier D.; Leclerc L.; Bausch B.; Berdelou A.; Sukurai A.; Vlcek P.; Krajewska J.; Barontini M.; Vaz Ferreira Vargas C.; Valerio L.; Ceolin L.; Akshintala S.; Hoff A.; Godballe C.; Jarzab B.; Jimenez C.; Eng C.; Imai T.; Schlumberger M.; Grubbs E.; Dralle H.; Neumann H.P.; Baudin E.; Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. Lancet Diabetes Endocrinol 2019,7(3),213-220","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1089\/thy.2018.0385","volume":"29","author":"Qi X.P.","year":"2019","unstructured":"Qi X.P.; Jin B.Y.; Li P.F.; Wang S.; Zhao Y.H.; Cao Z.L.; Yu X.H.; Cheng J.; Fang X.D.; Zhao J.Q.; RET S409Y Germline mutation and associated medullary thyroid carcinoma. Thyroid 2019,29(10),1447-1456","journal-title":"Thyroid"}],"container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/183694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.eurekaselect.com\/183694\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eurekaselect.com\/article\/download\/183694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T14:53:39Z","timestamp":1641999219000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/183694\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666200713092633","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}