{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:19:54Z","timestamp":1793841594699,"version":"4.6.1"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Thyroid peroxidase (TPO) gene mutation leads to a change in enzyme built\nstructure resulting in the anti-TPO autoantibodies production that may cause thyroid destruction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>To evaluate the association of three single nucleotide polymorphisms (SNPs) of the TPO gene\nand anti-TPO levels in Egyptian patients with autoimmune hypothyroidism and correlate them with the\ndisease severity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> Two hundred patients with newly discovered autoimmune hypothyroidism were included in\nthe study (100 with subclinical hypothyroidism and 100 of them with overt hypothyroidism) and 100\nhealthy individuals as a control group were genotyped by PCR-REFLP.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The TT genotype of rs2071400 C\/T and the T allele were significantly more frequent in patients\nwith subclinical hypothyroidism and overt hypothyroidism than in the control group. But there were no\nsignificant differences in the TT genotype and T allele between subclinical and overt hypothyroidism\npatients. As regards TPO rs732609 A\/C polymorphism, the CC genotype of rs732609 A\/C and the C\nallele were significantly increased in patients with subclinical hypothyroidism and overt hypothyroidism\nthan in controls. There was a significant difference in the CC genotype and C allele between subclinical\nand overt hypothyroidism patients. Concerning TPO rs1126797 C\/T polymorphism, there were no\nsignificant differences of genotype or allele frequencies between patients groups and control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>We found an association of rs2071400 C\/T and rs732609A\/C polymorphisms with autoimmune hypothyroidism and correlated anti-TPO levels with different genotypes in hypothyroid patients. Also, we found an association of rs732609A\/C polymorphism with the disease severity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200715101907","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T05:16:21Z","timestamp":1594876581000},"page":"734-742","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti- TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-8611","authenticated-orcid":true,"given":"Hanan S.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig,Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman A.M.","family":"Nsrallah","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig,Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza H.","family":"Abdel-Fatah","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig,Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira A.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig,Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer A.","family":"Fikry","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig,Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/BOR.0b013e32834ddb27","volume":"24","author":"Stathatos N.","year":"2012","unstructured":"Stathatos N.; Daniels G.H.; Autoimmune thyroid disease. 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