{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:59:03Z","timestamp":1784948343332,"version":"3.55.0"},"reference-count":45,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,2,12]]},"abstract":"<jats:sec>\n<jats:title>Background and Objective:<\/jats:title>\n<jats:p>Carpal tunnel syndrome (CTS) is the most common form of\nnerve entrapment. Clinically, various signs and symptoms compare due to overexposure to mechanical\nvibrations transmitted to the wrist bones and cartilage, resulting in compression of the sensory and\nmotor nerve fibers of the median nerve. Early symptoms include nocturnal paresthesia and electromyography\nreveals reduced sensory nerve conduction velocity. Aim of this study was to evaluate the efficacy\nof a dietary integrator composed of acetyl-L-carnitine, \u03b1-lipoic acid, quercetin, bromelain, pantothenic\nacid, C and B1 and B2 and B6 and B12 vitamins in patients with early (minimal) carpal tunnel\nsyndrome.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> 36 patients (28 female and 8 male) with early CTS characterized by sensory nerve demyelination\nand inflammation of the transverse carpal ligament. Patients were divided into two groups,\ngroup A (18 patients received physical therapy) and group B (18 patients received physical therapy and\nan oral integrator). Clinical (sleep quality questionnaire to measure severity of paresthesia) and neurophysiological\nassessment (Sensory Nerve Conduction Velocity) performed at baseline, and then at 30\nand 60 days after treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Sleep quality and Sensory Nerve Conduction Velocity data analysis show improvement in\nboth groups at 30 and 60 days, with statistical difference between them in both time of analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>In the early CTS, with sensory fibers damage, use of dietary integrator, such as Micronil\nDol\u00ae, composed of acetyl-L-carnitine, \u03b1-lipoic acid, quercetin, bromelain, pantothenic acid, C and B1\nand B2 and B6 and B12 vitamins can be effective in quick recovery of median nerve sensory.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200728152953","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T06:25:43Z","timestamp":1596003943000},"page":"345-351","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome"],"prefix":"10.2174","volume":"21","author":[{"given":"Riccardo","family":"Marvulli","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari \u201cAldo Moro\u201d, Policlinico of Bari, Piazza G. 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