{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:17:35Z","timestamp":1792685855691,"version":"4.5.0"},"reference-count":34,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,1,26]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>We aimed prospectively to investigate the laboratory and electrocardiographic\nparameters (heart rate, QRS, QT, QTc, Tpe, Tpe\/QTc, and arrhythmia prevalence) in patients with\nGraves\u2019 disease before and after antithyroid therapy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Seventy-one patients (48 female, and 23 male), of age between 18-50 years (mean\u00b1SD:\n36.48\u00b112.20) with GD were included in the study. Patients were treated with antithyroid therapy\n(thioamides and\/or surgical therapy) to maintain euthyroid status. Patients were examined in terms of\nelectrocardiographic parameters before and after the treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>ean TSH, free thyroxin (fT4), and tri-iodothyrionine (fT<jats:sub>3<\/jats:sub>) levels of all patients were\n0.005\u00b10.21, 3.27\u00b1 1.81, 11.42\u00b17.44, respectively. While 9 patients (group 2) underwent surgical therapy,\nhad suspicious malignant nodule or large goiter, and unresponsiveness to medical treatment; the\nother patients (n=62, group 1) were treated with medical therapy. Patients with surgical therapy had\nmore increased serum fT4 (p=0.045), anti-thyroglobulin value (p=0.018) and more severe graves orbitopathy\n(n=0.051) before treatment when compared to a medical therapy group. Baseline Tpe duration\nand baseline Tpe\/QTc ratio and frequency of supraventricular ectopic beats were found to be significantly\nhigher in group 2 when compared to group 1 (p=0.00, p=0.005). Otherwise, the baseline mean\nheart rate, QRS duration, QTc values of both groups were similar. Although the patients came at their\neuthyroid status, group 2 patients still suffered from more sustained supraventricular ectopics beats\nthan group 1.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Distinct from the medical treatment group, surgical treatment group with euthyroidism for\nat least 3 months still suffered from an arrhythmia (Tpe, Tpe\/QTc, supraventricular and ventricular\nectopic beats).<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200729145100","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T08:06:16Z","timestamp":1596960376000},"page":"183-191","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of 24-Hour Electrocardiogram Parameters in Patients with Graves\u2019 Disease Before and After Anti-Thyroid Therapy"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-159X","authenticated-orcid":true,"given":"Gamze","family":"Akku\u015f","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Cukurova University, Adana,Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-4754","authenticated-orcid":true,"given":"Yeliz","family":"S\u00f6kmen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Antakya State Hospital, Hatay,Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-4775","authenticated-orcid":true,"given":"Mehmet","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Antakya State Hospital, Hatay,Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zkan","family":"Bekler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay,Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-7027","authenticated-orcid":true,"given":"O\u011fuz","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay,Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1159\/000490384","volume":"7","author":"Kahaly G.J.","year":"2018","unstructured":"Kahaly G.J.; Bartalena L.; Heged\u00fcs L.; Leenhardt L.; Poppe K.; Pearce S.H.; 2018 European Thyroid association guideline for the management of Graves\u2019 hyperthyroidism. 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