{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:43Z","timestamp":1790268763596,"version":"4.1.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Hormonal contraceptives contain an Estrogen and\/or a Progestin, which are the substrates of\nthe CYP3A4 enzyme and the drugs inducing the CYP3A4 enzyme can decrease the plasma concentrations\nand thereby therapeutic efficacy of Hormonal contraceptives resulting in unintended pregnancy.\nMoreover, the hormonal contraceptives associated risk of thrombotic events are further exacerbated by\nthe simultaneous administration of drugs like Tranexamic acid and tobacco smoke. Therefore, while\nprescribing hormonal contraception and other drugs to women, drug interactions should always be\nconsidered because there could be a possible contraceptive failure or other adverse drug effects. This\narticle provides a summary of guidance to healthcare professionals such as prescribers and pharmacists\non pharmacokinetic based interactions between hormonal contraception and other drugs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200820092534","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T10:40:22Z","timestamp":1598006422000},"page":"1219-1231","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetic Approach of Clinically Important Drug Interactions of Hormonal Contraceptives \u2013 A Review"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-9783","authenticated-orcid":true,"given":"Naina M.P.","family":"Maideen","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Dubai Health Authority, PB No: 4545, Dubai, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-7800","authenticated-orcid":true,"given":"Rajkapoor","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam 638 183, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1454-9582","authenticated-orcid":true,"given":"Sambathkumar","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam 638 183, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185133\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T19:23:24Z","timestamp":1630005804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185133\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8,26]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666200820092534","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}