{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:12:26Z","timestamp":1756897946492},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","funder":[{"DOI":"10.13039\/501100006319","name":"CNRST","doi-asserted-by":"publisher","award":["PPR\/2015\/35"],"award-info":[{"award-number":["PPR\/2015\/35"]}],"id":[{"id":"10.13039\/501100006319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:sec>\n<jats:title>Aims:<\/jats:title>\n<jats:p>The aim of the study was to investigate the effect of aqueous aerial part extract of\nMentha pulegium L. (Pennyrile) (MPAE) on arterial pressure parameters in rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Mentha pulegium is a medicinal plant used to treat hypertension in the Moroccon\npopulation.\n<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In the current study, MPAE was prepared and its antihypertensive activity was pharmacologically\ninvestigated. L-NAME-hypertensive and normotensive rats received MPAE (180 and 300\nmg\/kg) orally for six hours for acute experiment and during seven days for the sub-chronic treatment.\nThereafter, systolic, diastolic, mean arterial blood pressure and heart rate were evaluated. In\nthe in vitro experiment, isolated denuded and intact thoracic aortic rings were suspended in a tissue\nbath system and the tension changes were recorded.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A fall in blood pressure was observed in L-NAME-induced hypertensive treated with\nMPAE. The extract also produced a dose-dependent relaxation of aorta pre-contracted with NE and\nKCl. The study showed that the vasorelaxant ability of MPAE seems to be exerted through the\nblockage of extracellular Ca<jats:sup>2+<\/jats:sup> entry.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> The results demonstrate that the extract of pennyrile exhibits antihypertensive activity.\nIn addition, the effect may be, at least in part, due to the dilation of blood vessels via blockage\nof Ca<jats:sup>2+<\/jats:sup> channels.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200909093908","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T11:55:15Z","timestamp":1599652515000},"page":"1289-1299","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vasorelaxant and Antihypertensive Effects of Mentha pulegium L. in Rats: An In vitro and In vivo Approach"],"prefix":"10.2174","volume":"21","author":[{"given":"Mohammed","family":"Ajebli","sequence":"first","affiliation":[{"name":"Department of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Eddouks","sequence":"additional","affiliation":[{"name":"Department of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185755\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T19:23:33Z","timestamp":1630005813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185755\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8,26]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666200909093908","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}