{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:41:33Z","timestamp":1774352493156,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>We evaluated cardiovascular (CV) risk stratification for nonfunctioning adrenal incidentalomas\n(NFAIs) via the coronary-artery-calcium (CAC) score.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Method:<\/jats:title>\n<jats:p>The participants were patients with NFAI (n = 55). They were compared\nto patients with chest pain, a low-intermediate Framingham-risk score, and a non-diagnostic treadmill-\nexercise test, which served as the control group (n = 49). Subsequently, the NFAI group was\nsubdivided according to a CAC score of &lt;100 Agatston units \u2013 mild coronary-artery calcification\n(n = 40) \u2013 and \u2265100 Agatston units \u2013 moderate-to-severe calcification (n = 15).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Similar rates of traditional risk factors were observed between the NFAI and control\ngroups, and lower low-density lipoprotein cholesterol rates were observed in the NFAI group. The\nCAC score was significantly higher for the NFAI group than the control group. Glucose, potassium,\nadrenocorticotropic-hormone, and basal-cortisol levels were higher in those with a CAC score\nof \u2265100. High-density-lipoprotein cholesterol estimated glomerular filtration rate and ejection fraction\n(EF) were higher in those with a CAC score of &lt;100. Adenoma size and location were similar\nbetween the groups. Age, EF, and glucose were the most significant variables related to CAC score\nin patients with NFAI, at \u2265100 Agatston units.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Discussion:<\/jats:title>\n<jats:p> Patients with a low-intermediate CV risk profile and NFAI have a higher risk of\natherosclerosis when compared to patients with a low-intermediate CV risk profile, but no NFAI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In patients with NFAI, CAC score evaluation may be used to predict increased\natherosclerosis, especially in patients of an older age with higher glucose and decreased EF.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200910110337","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T11:52:36Z","timestamp":1599825156000},"page":"1319-1325","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased Rates of Coronary Artery Calcium Score in Patients with Non - Functioning Adrenal Incidentaloma"],"prefix":"10.2174","volume":"21","author":[{"given":"Oguz","family":"Akkus","sequence":"first","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Akkus","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Antakya State Hospital, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Kaypakli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma K.","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Gurkan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozkan","family":"Bekler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185812\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T19:23:37Z","timestamp":1630005817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185812\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8,26]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666200910110337","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}