{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T06:53:41Z","timestamp":1683183221946},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,10,8]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>Primary hyperparathyroidism (PHPT) is rare in pregnancy. PHPT and hypercalcemia\nare associated with negative maternofetal outcomes. Therefore, an early diagnosis and\nadequate treatment are essential.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case Presentation:<\/jats:title>\n<jats:p>We described the case of a pregnant woman complaining of nausea, vomiting\nand weight loss. Diagnosis of gestational PHPT (GPHPT) was made based on elevated serum calcium\nand parathyroid hormone levels (3.4 mmol\/L and 41.6 pmol\/L). Neck ultrasound documented a\nnodule suggestive of enlarged parathyroid, whereas the abdomen ultrasound revealed renal microlithiasis.\nConservative treatment was started with oral hydration and a low-calcium diet. Clinical\nand biochemical monitoring was weekly and multidisciplinary. Despite our suggestion, the patient\nrefused parathyroidectomy in the second trimester. Additional intravenous fluid rehydration\nfrom the 15th to the 25th week of gestation ameliorated the symptoms rapidly, and reduced calcium\nlevels progressively from the 23rd week. At week 40, the woman gave birth to a healthy girl. At\nmonth 8 postpartum, calcemia and PTH were still elevated, and accompanied by osteoporosis and\nnephrocalcinosis. Surgery was accepted, and a parathyroid adenoma was removed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In the absence of guidelines for GPHPT management, its treatment should be individualized.\nIn our case, despite high calcium levels, conservative treatment with strict monitoring led\nto a positive outcome of pregnancy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666201007151331","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:18:43Z","timestamp":1602148723000},"page":"1512-1517","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Conservative Management of Gestational Hypercalcemia Due to Primary Hyperparathyroidism with Lack of Complications"],"prefix":"10.2174","volume":"21","author":[{"given":"Flavia","family":"Di Bari","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Vita","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Borrielli","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, A.O.U. Policlinico G. Martino, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Lo Re","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, A.O.U. Policlinico G. Martino, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Panebianco","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery, San Vincenzo Hospital, Taormina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Benvenga","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186718\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T14:59:36Z","timestamp":1633964376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186718\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,10,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666201007151331","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}