{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:32:24Z","timestamp":1791977544517,"version":"4.4.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The beneficial effects of vitamin D, together with the high prevalence of\nvitamin D deficiency, have led to an expanding use of vitamin D analogues. While inappropriate\nconsumption is a recognized cause of harm, the determination of doses at which vitamin D becomes\ntoxic remains elusive.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case presentation:<\/jats:title>\n<jats:p>A 56-year woman was admitted to our Hospital following a 3-week history of\nnausea, vomiting, and muscle weakness. The patient had been assuming a very high dose of cholecalciferol\nfor 20 months (cumulative 78,000,000UI, mean daily 130,000UI), as indicated by a non--\nconventional protocol for multiple sclerosis. Before starting vitamin D integration, serum calcium\nand phosphorus levels were normal, while 25OH-vitamin D levels were very low (12.25 nmol\/L).\nOn admission, hypercalcemia (3.23 mmol\/L) and acute kidney injury (eGFR 20 mL\/min) were detected,\nassociated with high concentrations of 25OH-vitamin D (920 nmol\/L), confirming the suspicion\nof vitamin D intoxication. Vitamin D integration was stopped, and in a week, hypercalcemia\nnormalized. It took about 6 months for renal function and 18 months for vitamin D values to go\nback to normal.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>This case confirms that vitamin D intoxication is possible, albeit with a high dose.\nThe doses used in clinical practice are far lower than these and, therefore, intoxication rarely occurs\neven in those individuals whose baseline vitamin D serum levels have never been assessed. Repeated\nmeasurements of vitamin D are not necessary for patients under standard integrative therapy.\nHowever, patients and clinicians should be aware of the potential dangers of vitamin D overdose.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666201007152230","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:18:43Z","timestamp":1602148723000},"page":"1653-1659","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["How Much Vitamin D is Too Much? A Case Report and Review of the Literature"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-5683","authenticated-orcid":true,"given":"Sara","family":"De Vincentis","sequence":"first","affiliation":[{"name":"Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Russo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Unit of Metabolic Medicine, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9886-0698","authenticated-orcid":true,"given":"Amedeo","family":"Lonardo","sequence":"additional","affiliation":[{"name":"Unit of Metabolic Medicine, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-3921","authenticated-orcid":true,"given":"Maria C.","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-0696","authenticated-orcid":true,"given":"Vincenzo","family":"Rochira","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2133-4304","authenticated-orcid":true,"given":"Manuela","family":"Simoni","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-982X","authenticated-orcid":true,"given":"Bruno","family":"Madeo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186719\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T10:11:38Z","timestamp":1637835098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186719\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666201007152230","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}