{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:15:34Z","timestamp":1754486134552},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,9]]},"abstract":"\nBackground:<\/jats:title>\nAsthenospermia is defined as the forward motility of sperm less than\n32%.<\/jats:p>\n<\/jats:sec>\n\nAim\/Objective:<\/jats:title>\nThis study aimed to establish a mouse model of asthenospermia through triggering\nD-galactose mediated oxidative stress.<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:title>\n A total of 40 Kunming male mice were randomly divided into control group, low-dose\ngroup (administrating D-galactose at 60 mg\/kg), high-dose group (administrating D-galactose at\n120 mg\/kg), and high-dose+feed addition group (administrating D-galactose at 120 mg\/kg together\nwith oral D-galactose). The testicular weight, testicular organ coefficient, sperm viability, sperm\nconcentration, and survival rate of the tail of epididymis were measured. Oxidative damage of D--\ngalactose to the reproductive system of mice was evaluated by measuring superoxide dismutase\n(SOD) and malondialdehyde (MDA) in the testicular homogenate of mice.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\n The sperm motility, motility rate, concentration, and survival rate of low-dose, high-dose\nand high-dose+feed addition group were decreased, compared to that in the control group. However,\nthere background:was a significant difference between high-dose group\/high dose+feed group\nand the control group (p<0.05): the forward motile sperm motility rate and total motility rate are accorded\nwith critical criteria of asthenospermia. As compared with the control group, the activity of\nSOD of model group mice significantly decreased, and MDA concentration significantly increased\n(p<0.05), except for low-dose versus control group for SOD activity. This suggests that testicular\ntissues suffered from oxidative damage.<\/jats:p>\n<\/jats:sec>\n\nConclusions:<\/jats:title>\n This study successfully established a mouse asthenospermia model through D-galactose\nmediated oxidative stress injury. The establishment of asthenospermia model in this study\nwould provide new promising insight and act as a potential approach for studying asthenospermia\nin vivo levels.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666201116111142","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T10:50:22Z","timestamp":1605610222000},"page":"1634-1640","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of a Mouse Asthenospermia Model through Triggering D-Galactose Mediated Oxidative Stress Injury"],"prefix":"10.2174","volume":"21","author":[{"given":"Nanjun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Endocrine, Metabolic & Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/188000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/188000\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/188000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T10:11:33Z","timestamp":1637835093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/188000\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530320666201116111142","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}