{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:42:47Z","timestamp":1778622167562,"version":"3.51.4"},"reference-count":33,"publisher":"Bentham Science Publishers Ltd.","issue":"1","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["206\/2018"],"award-info":[{"award-number":["206\/2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["BIOT"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Early childhood caries is a sugar-dependent disease with multifactorial modulating factors affecting deciduous dentition. It is defined as the presence of at least one decayed tooth, absence of a tooth due to caries or the existence of a temporary restoration in a tooth in a child between zero and 71 months of age. No BRP varnish was found in intellectual property banks, therefore it was registered and deposited with patent number BR1020160190142.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The objective of this study was to evaluate the dose-response concentration of alcoholic extract of Brazilian red propolis (BRP), in the form of dental varnish, against Streptococcus mutans (S. mutans) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Twenty-four children, aged between 36 and 71 months, of both genders and without caries, were selected to participate in this pilot study and grouped randomly into four groups to receive different concentrations of BRP varnish (1%, 2.5%, 5% and 10%). The varnish was applied to the surface of all second deciduous molars. The antimicrobial activity was observed in saliva, which was collected in two phases: before applying the BRP varnish and after use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>There was microbiological reduction of S. mutans in the oral cavity of the children in all the tested concentrations. The highest percentage reduction of S. mutans was observed at the concentration of 2.5% (P = 0.0443).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The BRP extract in the form of dental varnish has antimicrobial activity against S. mutans and constitutes a possible alternative in the prevention of dental caries.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1872208313666190826145453","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T20:08:13Z","timestamp":1566850093000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dose-response Evaluation of Propolis Dental Varnish in Children: A Randomized Control Study"],"prefix":"10.2174","volume":"14","author":[{"given":"Edilson Martins Rodrigues","family":"Neto","sequence":"first","affiliation":[{"name":"Postgraduate Program in Drug Development, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00eddia Audrey Rocha","family":"Valadas","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Drug Development, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Leal Dantas","family":"Lobo","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Department of Pharmacology, School of Medicine, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Analice Mendes Barreto","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Drug Development, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said Gon\u00e7alves","family":"da Cruz Fonseca","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Drug Development, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Vagnaldo","family":"Fechine","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, School of Dentistry-Campus Sobral, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Josimar Gir\u00e3o","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Drug Development, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anne Medeiros","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Drug Development, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Maria","family":"de Fran\u00e7a Fonteles","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Catholic Center University, Quixada, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"31","volume":"27","year":"2005-2006","unstructured":"Policy on early childhood caries (ECC): classifications, consequences, and preventive strategies. 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