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The rapidly increasing financial and personal costs will affect the world's economies, health care systems, and many families. Researchers are now exploring a possible connection among AD, vascular dementia (VD), diabetes mellitus (type 2, T2DM) and cardiovascular diseases (CD). This correlation may be due to a strong association of cardiovascular risk factors with AD and VD, suggesting that these diseases share some biologic pathways. Since heart failure is associated with an increased risk of AD and VD, keeping the heart healthy may prove to keep the brain healthy as well. The risk for dementia is especially high when diabetes mellitus is comorbid with severe systolic hypertension or heart disease. In addition, the degree of coronary artery disease (CAD) is independently associated with cardinal neuropathological lesions of AD. Thus, the contribution of T2DM and CD to AD and VD implies that cardiovascular therapies may prove useful in preventing AD and dementia.<\/jats:p>","DOI":"10.2174\/1874091x01004010029","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T13:14:13Z","timestamp":1270646053000},"page":"29-52","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cardiovascular Dementia - A Different Perspective"],"prefix":"10.2174","volume":"04","author":[{"given":"Udhaya","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Heese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archneur.64.3.354","volume":"64","author":"Graff-Radford NR","year":"2007","unstructured":"Graff-Radford NR, Crook JE, Lucas J, et al. \n                Association of low plasma Abeta42\/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease \n                Arch Neurol  \n                2007; \n                64\n                : 354-62.","journal-title":"Arch. 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Alzheimer Res"},{"key":"refR30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.2174\/156720509787602861","volume":"6","author":"Pepeu G","year":"2009","unstructured":"Pepeu G, Giovannini MG. \n                Cholinesterase inhibitors and beyond \n                Curr Alzheimer Res  \n                2009; \n                6\n                : 86-96.","journal-title":"Curr. Alzheimer Res"},{"key":"refR31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1124\/pr.108.000562","volume":"61","author":"Buckingham SD","year":"2009","unstructured":"Buckingham SD, Jones AK, Brown LA, Sattelle DB. \n                Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection \n                Pharmacol Rev  \n                2009; \n                61\n                : 39-61.","journal-title":"Pharmacol. 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Alzheimers Dis"},{"key":"refR34","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.pneurobio.2008.03.002","volume":"85","author":"Wang JZ","year":"2008","unstructured":"Wang JZ, Liu F. \n                Microtubule-associated protein tau in development, degeneration and protection of neurons \n                Prog Neurobiol  \n                2008; \n                85\n                : 148-75.","journal-title":"Prog. 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Neuropathol"},{"key":"refR37","first-page":"341","volume":"107","author":"Iqbal K","year":"2006","unstructured":"Iqbal K, Novak M. \n                From tangles to tau protein \n                Bratisl Lek Listy  \n                2006; \n                107\n                : 341-2.","journal-title":"Bratisl. Lek. Listy"},{"key":"refR38","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1126\/science.1064684","volume":"293","author":"Lee VM","year":"2001","unstructured":"Lee VM. \n                Biomedicine. 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(Barc)"},{"key":"refR48","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0140-6736(92)92814-V","volume":"340","author":"Martin BC","year":"1992","unstructured":"Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. \n                Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study \n                Lancet  \n                1992; \n                340\n                : 925-.","journal-title":"Lancet"},{"key":"refR49","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrm2327","volume":"9","author":"Muoio DM","year":"2008","unstructured":"Muoio DM, Newgard CB. \n                Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes \n                Nat Rev Mol Cell Biol  \n                2008; \n                9\n                : 193-205.","journal-title":"Nat. Rev. Mol. 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