{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:29:53Z","timestamp":1759332593959},"reference-count":69,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2010,8,8]],"date-time":"2010-08-08T00:00:00Z","timestamp":1281225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openbiomedicalengineeringjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOBEJ"],"published-print":{"date-parts":[[2010,8,8]]},"abstract":"<jats:p>Diabetes mellitus (DM) has a growing incidence and prevalence in modern societies, pushed by the aging and change of life styles. Despite the huge resources dedicated to improve their quality of life, mortality and morbidity rates, these are still very poor. In this work, DM pathology is revised from clinical and metabolic points of view, as well as mathematical models related to DM, with the aim of justifying an evolution of DM therapies towards the correction of the physiological metabolic loops involved. We analyze the reliability of mathematical models, under the perspective of virtual physiological human (VPH) initiatives, for generating and integrating customized knowledge about patients, which is needed for that evolution. Wearable smart sensors play a key role in this frame, as they provide patient\u2019s information to the models.<\/jats:p>\n                <jats:p>A telehealthcare computational architecture based on distributed smart sensors (first processing layer) and personalized physiological mathematical models integrated in Human Physiological Images (HPI) computational components (second processing layer), is presented. This technology was designed for a renal disease telehealthcare in earlier works and promotes crossroads between smart sensors and the VPH initiative. We suggest that it is able to support a truly personalized, preventive, and predictive healthcare model for the delivery of evolved DM therapies.<\/jats:p>","DOI":"10.2174\/1874120701004010236","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T04:50:03Z","timestamp":1288932603000},"page":"236-249","update-policy":"http:\/\/dx.doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Smart Sensors and Virtual Physiology Human Approach as a Basis of Personalized Therapies in Diabetes Mellitus"],"prefix":"10.2174","volume":"4","author":[{"given":"Carlos M","family":"Fern\u00e1ndez Peruchena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Prado-Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.apnum.2005.04.023","volume":"56","author":"Makroglou A","year":"2006","unstructured":"Makroglou A, Li J, Kuang Y. \n                    \"Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: an overview\" \n                    Appl Numer Math  \n                    2006; \n                    56\n                    : 559-73.","journal-title":"Appl. Numer. Math"},{"key":"refR2","unstructured":"Guyton A C, Hall J E. \n                    Textbook of Medical Physiology.  Eleventh Edition. \n                    Elsevier Saunders 2006."},{"key":"refR3","first-page":"RA130","volume":"12","author":"Tripathi B K","year":"2006","unstructured":"Tripathi B K, Srivastava A K. \n                    \"Diabetes mellitus: complications and therapeutics\" \n                    Med Sci Monit  \n                    2006 July 1; \n                    \n                    \n                    12\n                    : RA130-47.","journal-title":"Med. Sci. Monit"},{"key":"refR4","unstructured":"WHO Consultation. \n                    \"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications\" \n                    1999.\n                    \n                 WHO WHO\/NCD\/NCS\/99.2"},{"key":"refR5","first-page":"RA359","volume":"11","author":"Haag M","year":"2005","unstructured":"Haag M, Dippenaar N G. \n                    \"Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection\" \n                    Med Sci Monit  \n                    2005; \n                    11\n                    : RA359-367.","journal-title":"Med. Sci. Monit"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1463-1326.2006.00642.x","volume":"9","author":"Shepherd J","year":"2007","unstructured":"Shepherd J. \n                    Dyslipidaemia in diabetic patients: time for a rethink \n                    Diabetes Obes Metab  \n                    2007; \n                    9\n                    : 609-16.","journal-title":"Diabetes Obes. Metab"},{"key":"refR7","unstructured":"\"Diabetes Action Now Initiative, \"Diabetes Action Now: an iniative\nof the World Health Organization and the International Diabetes\nFederation,\". \n                    Switzerland: WHO and IDF 2004."},{"key":"refR8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","volume":"27","author":"Wild S","year":"2004","unstructured":"Wild S, Roglic G, Green A, Sicree R, King H. \n                    Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030 \n                    Diabetes Care  \n                    2004 May  1; \n                    \n                    \n                    27\n                    : 1047-53.","journal-title":"Diabetes Care"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ijmedinf.2006.05.042","volume":"75","author":"Green C J","year":"2006","unstructured":"Green C J, Fortin P, Maclure M, Macgregor A, Robinson S. \n                    \"Information system support as a critical success factor for chronic disease management: Necessary but not sufficient\" \n                    Int J Med Inf  \n                    2006; \n                    75\n                    : 818-28.","journal-title":"Int. J. Med. Inf"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1109\/4233.720526","volume":"2","author":"Carson E R","year":"1998","unstructured":"Carson E R, Cramp D G, Morgan A, Roudsari A V. \n                    \"Clinical decision support, systems methodology, and telemedicine: their role in the management of chronic disease\" \n                    IEEE Trans Inf Technol Biomed  \n                    1998; \n                    2\n                    : 80-.","journal-title":"IEEE Trans. Inf. Technol. Biomed"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/diacare.28.11.2697","volume":"28","author":"Farmer A J","year":"2005","unstructured":"Farmer A J, Gibson O J, Dudley C, et al. \n                    \"A randomized controlled trial of the effect of real-time telemedicine support on glycemic control in young adults with type 1 diabetes (ISRCTN 46889446)\" \n                    Diabetes Care  \n                    2005 November 1; \n                    \n                    \n                    28\n                    : 2697-702.","journal-title":"Diabetes Care"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1089\/tmj.2006.12.50","volume":"12","author":"Wei J C","year":"2006","unstructured":"Wei J C, Valentino D J, Bell D S, Baker R S. \n                    \"A web-based telemedicine system for diabetic retinopathy screening using digital fundus photography\" \n                    Telemed J Health  \n                    2006; \n                    12\n                    : 50-7.","journal-title":"Telemed. J. Health"},{"key":"refR13","unstructured":"Medina J M, Medina F S d, Vargas A. \n                    \n                  Bioqu\u00edmica\n                     In: \n                    Madrid: Editorial Sintesis. \n                     1996."},{"key":"refR14","unstructured":"Kauffman S. \n                    Investigaciones In: \n                    Barcelona: Tusquet Editores. \n                     2003."},{"key":"refR15","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.pcbi.0040023","volume":"4","author":"Hintze A","year":"2008","unstructured":"Hintze A, Adami C. \n                    \"Evolution of complex modular biological networks\" \n                    PLoS Comput Biol  \n                    2008 February  01; \n                    \n                    \n                    4\n                    : e23.","journal-title":"PLoS Comput. Biol"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cell.2005.04.020","volume":"121","author":"Aderem A","year":"2005","unstructured":"Aderem A. \n                    \"Systems biology: Its practice and challenges\" \n                    Cell  \n                    2005; \n                    121\n                    : 511-3.","journal-title":"Cell"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/sj.ki.5002045","volume":"71","author":"O'Sullivan A J","year":"2006","unstructured":"O'Sullivan A J, Kelly J J. \n                    \"Insulin resistance and protein catabolism in non-diabetic hemodialysis patients\" \n                    Kidney Int  \n                    2006; \n                    71\n                    : 98-100.","journal-title":"Kidney Int"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"E890","DOI":"10.1152\/ajpendo.00359.2007","volume":"293","author":"Bertram R","year":"2007","unstructured":"Bertram R, Sherman A, Satin L S. \n                    \"Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion\" \n                    Am J Physiol Endocrinol Metab  \n                    2007 October 1; \n                    \n                    \n                    293\n                    : E890-900.","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1172\/JCI107011","volume":"51","author":"Grodsky G","year":"1972","unstructured":"Grodsky G. \n                    \"A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling\" \n                    J Clin Investig  \n                    1972; \n                    51\n                    : 2047-59.","journal-title":"J. Clin. Investig"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF02558793","volume":"35","author":"Licko V","year":"1973","unstructured":"Licko V. \n                    \"Threshold secretory mechanism: a model of derivative element in biological control\" \n                    Bull Math Biol  \n                    1973; \n                    35\n                    : 51-8.","journal-title":"Bull. Math. Biol"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2362.1974.tb02345.x","volume":"4","author":"Cerasi E","year":"1974","unstructured":"Cerasi E, Fick G, Rudemo M. \n                    \"A mathematical model for the glucose induced insulin release in man\" \n                    Eur J Clin Investig  \n                    1974; \n                    4\n                    : 267-78.","journal-title":"Eur. J. Clin. Investig"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2337\/diab.29.12.979","volume":"29","author":"Toffolo G","year":"1980","unstructured":"Toffolo G, Bergman R, Finegood D, Bowden C, Cobelli C. \n                    \"Quantitative estimation of beta cell sensitivity to glucose in the intact organism: a minimal model of insulin kinetics in the dog\" \n                    Diabetes  \n                    1980; \n                    29\n                    : 979-90.","journal-title":"Diabetes"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1006\/jtbi.2000.2150","volume":"206","author":"Topp B","year":"2000","unstructured":"Topp B, Promislow K, deVries G, Miura R, Finegood D. \n                    \"A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes\" \n                    J Theor Biol  \n                    2000; \n                    206\n                    : 605-19.","journal-title":"J. Theor. Biol"},{"key":"refR24","unstructured":"Hernandez R, Lyles D, Rubin D, Voden T, Wirkus S. \n                    \"A model of beta-cell mass, insulin, glucose, and receptor dynamics with applications to diabetes\" \n                    Cornell University Department of Biological Statistics and Computational Biology Technical Report BU-1579-M \n                    2001."},{"key":"refR25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/45280","volume":"402","author":"Maechler P","year":"1999","unstructured":"Maechler P, Wollheim C B. \n                    \"Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis\" \n                    Nature  \n                    1999; \n                    402\n                    : 685-9.","journal-title":"Nature"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.bulm.2003.12.005","volume":"66","author":"Bertram R","year":"2004","unstructured":"Bertram R, Sherman A. \n                    \"A calcium-based phantom bursting model for pancreatic islets\" \n                    Bull Math Biol  \n                    2004; \n                    66\n                    : 1313-44.","journal-title":"Bull. Math. Biol"},{"key":"refR27","first-page":"E667","volume":"236","author":"Bergman R","year":"1979","unstructured":"Bergman R, Ider Y, Bowden C, Cobelli C. \n                    \"Quantitative estimation of insulin sensitivity\" \n                    Am J Physiol  \n                    1979; \n                    236\n                    : E667-77.","journal-title":"Am. J. Physiol"},{"key":"refR28","first-page":"119","volume":"4","author":"Himsworth H","year":"1939","unstructured":"Himsworth H, Ker R. \n                    \"Insulin-sensitive and insulin insensitive types of diabetes mellitus\" \n                    Clin Sci  \n                    1939; \n                    4\n                    : 119-22.","journal-title":"Clin. Sci"},{"key":"refR29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1152\/jappl.1961.16.5.783","volume":"16","author":"Bolie V","year":"1961","unstructured":"Bolie V. \n                    \"Coefficients of normal blood glucose regulation\" \n                    J Appl Physiol  \n                    1961; \n                    16\n                    : 783-8.","journal-title":"J. Appl. Physiol"},{"key":"refR30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0021-9290(02)00055-6","volume":"35","author":"Derouich M","year":"2002","unstructured":"Derouich M, Boutayeb A. \n                    \"The effect of physical exercise on the dynamics of glucose and insulin\" \n                    J Biomech  \n                    2002; \n                    35\n                    : 911-7.","journal-title":"J. Biomech"},{"key":"refR31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s002850050007","volume":"40","author":"De Gaetano A","year":"2000","unstructured":"De Gaetano A, Arino O. \n                    \"Mathematical Modelling of the Intravenous Glucose Tolerance Test\" \n                    J Math Biol  \n                    2000; \n                    40\n                    : 136-68.","journal-title":"J. Math. Biol"},{"key":"refR32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0895-7177(00)00020-0","volume":"31","author":"De Gaetano A","year":"2000","unstructured":"De Gaetano A, Arino O. \n                    \"A statistical approach to the determination of stability for dynamical systems modelling physiological processes\" \n                    Math Comput Model  \n                    2000; \n                    31\n                    : 41-51.","journal-title":"Math. Comput. Model"},{"key":"refR33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3934\/dcdsb.2004.4.407","volume":"4","author":"Mukhopadhyay A","year":"2004","unstructured":"Mukhopadhyay A, De Gaetano A, Arino O. \n                    \"Modelling the intravenous glucose tolerance test: A global study for single-distributed- delay model\" \n                    Discr Cont Dyn Syst Ser B  \n                    2004; \n                    4\n                    : 407-17.","journal-title":"Discr. Cont. Dyn. Syst. Ser. B"},{"key":"refR34","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1350-4533(02)00147-9","volume":"24","author":"Lam Z","year":"2002","unstructured":"Lam Z, Hwang K, Lee J, Chase J, Wake G. \n                    \"Active insulin infusion using optimal and derivative-weighted control\" \n                    Med Eng Phys  \n                    2002; \n                    24\n                    : 663-72.","journal-title":"Med. Eng. Phys"},{"key":"refR35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0169-2607(00)00071-7","volume":"62","author":"Nucci G","year":"2000","unstructured":"Nucci G, Cobelli C. \n                    \"Models of subcutaneous insulin kinetics. A critical review\" \n                    Comp Meth Progr Biomed  \n                    2000; \n                    62\n                    : 249-57.","journal-title":"Comp. Meth. Progr. Biomed"},{"key":"refR36","unstructured":"Prado M, Roa L. \n                    \n                    \"Simulation Languages\" In: M A, Ed. \n                    Wiley Encyclopedia of Biomedical Engineering.  \n                    John Wiley and Sons, Inc 2006; pp. \n                    \n                    41-52."},{"key":"refR37","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1098\/rsta.2006.1769","volume":"364","author":"Mar\u00e9e A","year":"2006","unstructured":"Mar\u00e9e A, Kublik R, Finegood D, Edelstein-Keshet L. \n                    \"Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?\" \n                    Philos Transact A Math Phys Eng Sci  \n                    2006; \n                    364\n                    : 1267-82.","journal-title":"Philos. Transact. A Math. Phys. Eng. Sci"},{"key":"refR38","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.compchemeng.2006.10.004","volume":"31","author":"Hetherington J","year":"2007","unstructured":"Hetherington J, Bogle I, Saffrey P, et al. \n                    \"Addressing the challenges of multiscale model management in systems biology\" \n                    Comput Chem Eng  \n                    2007; \n                    31\n                    : 962-79.","journal-title":"Comput. Chem. Eng"},{"key":"refR39","first-page":"450","author":"Hucka M","year":"2002","unstructured":"Hucka M, Finney A, Sauro H, Bolouri H, Doyle J, Kitano H. \n                    \"The ERATO Systems Biology Workbench: enabling interaction and exchange between software tools for computational biology\" \n                    Pac Symp Biocomput  \n                    2002; \n                    450-61.","journal-title":"Pac. Symp. Biocomput"},{"key":"refR40","unstructured":"Watne D, Turney P, Watne D. \n                    Auditing EDP Systems \n                    2002."},{"key":"refR41","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00011-004-0357-2","volume":"53","author":"Elstein A","year":"2004","unstructured":"Elstein A. \n                    \"On the origins and development of evidence-based medicine and medical decision making\" \n                    Inflamm Res  \n                    2004; \n                    53\n                    : 184-9.","journal-title":"Inflamm. Res"},{"key":"refR42","unstructured":"Jacobson A, de Groot M, Samson J. \n                    Dimsdale J, Baum A. \n                    \"Quality of life research in patients with Diabetes Mellitus in Quality if Life in Behavior Medicine Research In: \n             \n                    Lawrence: Erlbaum Associates 1995."},{"key":"refR43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2337\/diacare.11.9.725","volume":"11","author":"waqqas s","year":"1988","unstructured":"waqqas s. \n                    DCCT Research Group. \n                    \"Reliability and validity of a diabetes quality of life measure for the diabetes control and complication trial (DCCT)\" \n                    Diabetes Care  \n                    1988; \n                    11\n                    : 725-32.","journal-title":"Diabetes Care"},{"key":"refR44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/diacare.15.2.166","volume":"15","author":"Lloyd C","year":"1992","unstructured":"Lloyd C, Matthews K, Wing R, Orchard T. \n                    \"Psychosocial factors and complications of IDDM\" \n                    Diabetes Care  \n                    1992; \n                    15\n                    : 166-72.","journal-title":"Diabetes Care"},{"key":"refR45","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2337\/diacare.15.7.877","volume":"15","author":"Selam J","year":"1992","unstructured":"Selam J, Micossi P, Dunn F. \n                    \"Clinical trial of programmable implantable insulin pump for Type I diabetes\" \n                    Diabetes Care  \n                    1992; \n                    15\n                    : 877-85.","journal-title":"Diabetes Care"},{"key":"refR46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"Ware J","year":"1992","unstructured":"Ware J, Sherbourne C. \n                    \"The MOS 36-Item Short Form From Health Survey (SF-36). Conceptual framework and item selection\" \n                    Med Care  \n                    1992; \n                    30\n                    : 473-83.","journal-title":"Med. Care"},{"key":"refR47","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1176\/ajp.145.8.976","volume":"145","author":"Wells K","year":"1988","unstructured":"Wells K, Golding J, Burnam M. \n                    \"Psychiatric disorder in a sample of the general population with and without chronic medical conditions\" \n                    Am J Psychiatry  \n                    1988; \n                    145\n                    : 976-81.","journal-title":"Am. J. Psychiatry"},{"key":"refR48","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/bmj.38922.650521.80","volume":"333","author":"Marshall S M","year":"2006","unstructured":"Marshall S M, Flyvbjerg A. \n                    \"Prevention and early detection of vascular complications of diabetes\" \n                    BMJ (Clinical Research Ed)  \n                    2006 September 2; \n                    \n                    \n                    333\n                    : 475-80.","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"refR49","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1210\/en.2006-0152","volume":"147","author":"Hattersley A T","year":"2006","unstructured":"Hattersley A T, Pearson E R. \n                    \"Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, {beta}-cell physiology, and genetics in diabetes\" \n                    Endocrinology  \n                    2006 June 1; \n                    \n                    \n                    147\n                    : 2657-63.","journal-title":"Endocrinology"},{"key":"refR50","doi-asserted-by":"crossref","first-page":"758","DOI":"10.2337\/diacare.28.3.758","volume":"28","author":"Codner E","year":"2005","unstructured":"Codner E, Flanagan S, Ellard S, Garcia H, Hattersley A T. \n                    \"High-dose glibenclamide can replace insulin therapy despite transitory diarrhea in early-onset diabetes caused by a novel R201L Kir6.2 mutation\" \n                    Diabetes Care  \n                    2005 March 1; \n                    \n                    \n                    28\n                    : 758-9.","journal-title":"Diabetes Care"},{"key":"refR51","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00125-005-1731-5","volume":"48","author":"Klupa T","year":"2005","unstructured":"Klupa T, Edghill E, Nazim J, et al. \n                    \"The identification of a R201H mutation in KCNJ11, which encodes Kir6.2, and successful transfer to sustained-release sulphonylurea therapy in a subject with neonatal diabetes: evidence for heterogeneity of beta cell function among carriers of the R201H mutation\" \n                    Diabetologia  \n                    2005 May 1; \n                    \n                    \n                    48\n                    : 1029-31.","journal-title":"Diabetologia"},{"key":"refR52","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1210\/jc.2004-1241","volume":"89","author":"Zung A","year":"2004","unstructured":"Zung A, Glaser B, Nimri R, Zadik Z. \n                    \"Glibenclamide Treatment in Permanent Neonatal Diabetes Mellitus due to an Activating Mutation in Kir6.2\" \n                    J Clin Endocrinol Metab  \n                    2004 November 1; \n                    \n                    \n                    89\n                    : 5504-7.","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"refR53","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2337\/dc06-1628","volume":"30","author":"Malecki M T","year":"2007","unstructured":"Malecki M T, Skupien J, Klupa T, et al. \n                    \"Transfer to sulphonylurea therapy in adult subjects with permanent neonatal diabetes due to KCNJ11-activating mutations: evidence for improvement in insulin sensitivity\" \n                    Diabetes Care  \n                    2007 January 1; \n                    \n                    \n                    30\n                    : 147-9.","journal-title":"Diabetes Care"},{"key":"refR54","doi-asserted-by":"crossref","unstructured":"Knopf G, Bassi A. \n                    Smart Biosensor Technology. \n                     2006.","DOI":"10.1201\/9781420019506"},{"key":"refR55","doi-asserted-by":"crossref","unstructured":"Prado-Velasco M, R\u00edo-Cidoncha M G d, Ort\u00edz-Mar\u00edn R. \n                    \"The Inescapable Smart Impact detection System (ISIS): an\nubiquitous and personalized fall detector based on a distributed\n\"divide and conquer strategy\" \n                    \n                     In: Personalized Healthcare through Technology, 30th Annual International Conference of the\nIEEE Engineering in Medicine and Biology Society; \n                    Vancouver, British Columbia, Canada. 2008; pp. \n                    3332-5.","DOI":"10.1109\/IEMBS.2008.4649918"},{"key":"refR56","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1109\/JPROC.2006.871765","volume":"94","author":"Coatrieux J-L","year":"2006","unstructured":"Coatrieux J-L, Bassingthwaighte J. \n                    \"Special issue on the physiome and beyond\" \n                    Proc IEEE  \n                    2006; \n                    94\n                    : 671-7.","journal-title":"Proc. IEEE"},{"key":"refR57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00424-002-0890-1","volume":"445","author":"Hunter P","year":"2002","unstructured":"Hunter P, Robbins P, Noble D. \n                    \"The IUPS human physiome project\" \n                    Eur J Physiol  \n                    2002; \n                    445\n                    : 1-9.","journal-title":"Eur. J. Physiol"},{"key":"refR58","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1114\/1.1315650","volume":"28","author":"Ngon D","year":"2000","unstructured":"Ngon D, Patrick J M, Dewey C F. \n                    \"The human physiome as an information environment\" \n                    Ann Biomed Eng  \n                    2000; \n                     28\n                    : 1032.","journal-title":"Ann. Biomed. Eng"},{"key":"refR59","unstructured":"Bronzino J D. \n                    \"The biomedical engineering handbook\" In: \n                    in The Electrical engineering handbook series.  2nd. \n                    Florida: CRC Press 2000; 2: p. \n                    \n                    \n                    \n                    \n                    1512."},{"key":"refR60","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1109\/JPROC.2006.871767","volume":"94","author":"Hunter P J","year":"2006","unstructured":"Hunter P J. \n                    \"Modeling human physiology: The IUPS\/EMBS physiome project\" \n                    Proc IEEE  \n                    2006; \n                    94\n                    : 678-91.","journal-title":"Proc. IEEE"},{"key":"refR61","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1109\/TBME.2002.805454","volume":"49","author":"Prado M","year":"2002","unstructured":"Prado M, Roa L, Reina-Tosina J, Palma A, Mil\u00e1n J A. \n                    Virtual center for renal support: technological approach to Patient Physiological Image \n                    IEEE Trans Biomed Eng  \n                    2002 Dec; \n                    \n                    49\n                    : 1420-30.","journal-title":"IEEE Trans. Biomed. Eng"},{"key":"refR62","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ijmedinf.2006.03.005","volume":"75","author":"Prado M","year":"2006","unstructured":"Prado M, Roa L M, Reina-Tosina J. \n                    \"Viability study of a personalized and adaptive knowledge-generation telehealthcare system for nephrology (NEFROTEL)\" \n                    Int J Med Inf  \n                    2006; \n                    75\n                    : 646-57.","journal-title":"Int. J. Med. Inf"},{"key":"refR63","doi-asserted-by":"crossref","unstructured":"Hood L. \n                    \"Systems Biology and Systems Medicine: From Reactive to Predictive, Personalized, Preventive and Participatory Medicine\" \n                    \n                     In: Personalized Healthcare through Technology, 30th\nAnnual International Conference of the IEEE Engineering in\nMedicine and Biology Society; \n                    Vancouver, British Columbia. 2008.","DOI":"10.1109\/IEMBS.2008.4649061"},{"key":"refR64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/153056203766437499","volume":"9","author":"Prado M","year":"2003","unstructured":"Prado M, Roa L, Reina-Tosina J, Palma A, Mil\u00e1n J A. \n                    \"Renal telehealthcare system based on a patient physiological image: a novel hybrid approach in telemedicine\" \n                    Telemed J Health  \n                    2003; \n                    9\n                    : 149-65.","journal-title":"Telemed. J. Health"},{"key":"refR65","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s001250051671","volume":"44","author":"Bardoux P","year":"2001","unstructured":"Bardoux P, Ahloulay M, Le Maout S, Bankir L, Trinh-Trang-Tan M. \n                    \"Aquaporin-2 and urea transporter-A1 are up-regulated in rats with type I diabetes mellitus\" \n                    Diabetologia  \n                    2001 May 1; \n                    \n                    \n                    44\n                    : 637-45.","journal-title":"Diabetologia"},{"key":"refR66","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.0894-0959.2004.17211.x","volume":"17","author":"Briggs J P","year":"2004","unstructured":"Briggs J P. \n                    \"Evidence-Based medicine in the dialysis unit: a few lessons from the USRDS and the NCDS and HEMO trials\" \n                    Semin Dial  \n                    2004; \n                    17\n                    : 136-41.","journal-title":"Semin. Dial"},{"key":"refR67","first-page":"RA241","volume":"12","author":"Jenicek M","year":"2006","unstructured":"Jenicek M. \n                    \"Evidence-based medicine: Fifteen years later. Golem\nthe good, the bad, and the ugly in need of a review?\" \n                    Med Sci Monit  \n                    2006; \n                    12\n                    : RA241-251.","journal-title":"Med. Sci. Monit"},{"key":"refR68","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1472-6947-8-34","volume":"8","author":"Rosenbaum S","year":"2008","unstructured":"Rosenbaum S, Glenton C, Cracknell J. \n                    \"User experiences of evidence-based online resources for health professionals: User testing of The Cochrane Library\" \n                    BMC Med Inf Decis Mak  \n                    2008; \n                    8\n                    : 34.","journal-title":"BMC Med. Inf. Decis. Mak"},{"key":"refR69","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ijmedinf.2008.01.002","volume":"77","author":"Otieno G O","year":"2008","unstructured":"Otieno G O, Hinako T, Motohiro A, Daisuke K, Keiko N. \n                    \"Measuring effectiveness of electronic medical records systems: Towards building a composite index for benchmarking hospitals\" \n                    Int J Med Inf  \n                    2008; \n                    77\n                    : 657-69.","journal-title":"Int. J. Med. 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