{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:39:00Z","timestamp":1773236340903,"version":"3.50.1"},"reference-count":20,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T00:00:00Z","timestamp":1350259200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openbiomedicalengineeringjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOBEJ"],"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:p>We evaluated effects of an injectable complex of \u03b2-tricalcium phosphate (\u03b2-TCP) granules, hyaluronate, and recombinant human fibroblast growth factor-2 (rhFGF-2) on repair of unstable intertrochanteric fractures in elderly patients. Twenty-five patients (range, 76-91 years) having 31.A2 fractures (AO classification) were treated with injection of the complex followed by intramedullary nails. Bone regeneration and \u03b2-TCP resorption, unions of intertrochanteric fractures and displaced lesser trochanters to the shaft, and varus deformity of the femoral neck were assessed by X-ray and CT scans. Fracture union occurred in all cases and union of the displaced lesser trochanter to the shaft was obtained in 24 cases by 12 weeks. It is of interest that \u03b2-TCP granules were completely replaced by bone and marked new bone formation around the lesser trochanter was observed in all cases compared to cases not treated with the complex. This complex is a paste-like material that is easy to handle, and it may be of considerable use in treatment of both unstable intertrochanteric fractures and other cortical bone defects with minimal surgical invasion.<\/jats:p>","DOI":"10.2174\/1874120701206010098","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T05:44:06Z","timestamp":1350366246000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Use of an Injectable Complex of \u03b2-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures"],"prefix":"10.2174","volume":"6","author":[{"given":"T","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kitasato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Chazono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kumagae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mitsuhashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kakuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Marumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/(SICI)1097-4636(199602)30:2<193::AID-JBM9>3.0.CO;2-M","volume":"vol.30","author":"Ohura K","year":"1996","unstructured":"Ohura K, Bohner M, Hardouin P, Lemaitre J, Pasquier Flautre B. \u201cResorption of and bone formation from, new betatricalcium phosphate-monocalcium phosphate ceramics\u201d J Biomed Mater Res 1996; vol.30 : 193-200.","journal-title":"J. Biomed. Mater. Res"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/1097-4636(20001205)52:3<460::AID-JBM3>3.0.CO;2-U","volume":"vol.52","author":"Ohsawa K","year":"2000","unstructured":"Ohsawa K, Neo M, Matsuoka H, et al. \u201cThe expression of bone matrix protein mRNAs around beta-TCP particles implanted into bone\u201d J Biomed Mater Res 2000; vol.52 : 460-6.","journal-title":"J. Biomed. Mater. Res"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1016\/S0142-9612(02)00193-X","volume":"vol.23","author":"Dong J","year":"2002","unstructured":"Dong J, Uemura T, Shirasaki Y, Tateishi T. \u201cPromotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteogenitor cells\u201d Biomaterials 2002; vol.23 : 4493-502.","journal-title":"Biomaterials"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/jbm.10380","volume":"vol.63","author":"Ogose A","year":"2002","unstructured":"Ogose A, Hotta T, Hatano H, Kawashima H, Tokunaga K, Endo N. \u201cHistological examination of beta-tricalcium phosphate graft in human femur\u201d J Biomed Mater Res 2002; vol.63 : 601-4.","journal-title":"J. Biomed. Mater. Res"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jbm.a.30094","volume":"vol.15","author":"Chazono M","year":"2004","unstructured":"Chazono M, Tanaka T, Komaki H, Fujii K. \u201cBone formation and bioresorption after implantation of beta-tricalcium phosphate granules-hyaluronate complex in rabbit bone defects\u201d J Biomed Mater Res 2004; vol.15 : 542-9.","journal-title":"J. Biomed. Mater. Res"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/ten.2005.11.331","volume":"vol.11","author":"Tanaka T","year":"2005","unstructured":"Tanaka T, Komaki H, Chazono M, Fujii K. \u201cUse of a biphasic graft constructed with chondrocytes overlying a betatricalcium phosphate block in the treatment of rabbit osteochondral defects\u201d Tissue Eng 2005; vol.11 : 331-9.","journal-title":"Tissue Eng"},{"key":"refR7","first-page":"23","volume":"vol.53","author":"Tanaka T","year":"2006","unstructured":"Tanaka T, Chazono M, Komaki H. \u201cClinical application of beta-tricalcium phosphate in human bone defects\u201d Jikeikai Med J 2006; vol.53 : 23-31.","journal-title":"Jikeikai Med. J"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jbm.b.31041","volume":"vol.86","author":"Tanaka T","year":"2008","unstructured":"Tanaka T, Kumagae Y, Saito M, et al. \u201cBone formation and resorption in patients after implantation of beta-tricalcium phosphate blocks with 60% and 75% porosity in opening wedge high tibial osteotomy\u201d J Biomed Mater Res Part B Appl Biomater 2008; vol.86 : 453-9.","journal-title":"J. Biomed. Mater. Res. Part B Appl Biomater"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1016\/j.biomaterials.2006.05.031","volume":"vol.27","author":"Komaki H","year":"2006","unstructured":"Komaki H, Tanaka T, Chazono M, Kikuchi T. \u201cRepair of segmental bone defects in rabbit tibiae using a complex of betatricalcium phosphate, type I collagen, and fibroblast growth factor- 2\u201d Biomaterials 2006; vol.27 : 5118-26.","journal-title":"Biomaterials"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1210\/endo-125-4-2118","volume":"vol. 125","author":"McCarthy TL","year":"1989","unstructured":"McCarthy TL, Centrella M, Canalis E. \u201cEffects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells\u201d Endocrinology 1989; vol. 125 : 2118-6.","journal-title":"Endocrinology"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.109.1.1","volume":"vol.109","author":"Rifkin DB","year":"1989","unstructured":"Rifkin DB, Moscatelli D. \u201cRecent development in the cell biology of basic fibroblast growth factor\u201d J Cell Biol 1989; vol.109 : 1-6.","journal-title":"J. Cell Biol"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/endo.135.2.8033826","volume":"vol.135","author":"Kawaguchi H","year":"1994","unstructured":"Kawaguchi H, Kurokawa T, Hanada K, et al. \u201cStimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats\u201d Endocrinology 1994; vol.135 : 774-81.","journal-title":"Endocrinology"},{"key":"refR13","doi-asserted-by":"crossref","unstructured":"Muller ME, Allgower M, Schneider R, Willenegger H. Manual of internal fixation: techniques recommended by the AOASIF group. 3rd ed. Berlin Heidelberg, New York: Springer-Verlag 1991; pp. 270-81.","DOI":"10.1007\/978-3-662-02695-3"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/17453678909149323","volume":"vol. 60","author":"Aspenberg P","year":"1989","unstructured":"Aspenberg P, Lohmander LS. Fibroblast growth factor stimulates bone formation\u201d Acta Orthop Scand 1989; vol. 60 : 473-6.","journal-title":"Acta. Orthop. Scand"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jor.1100160605","volume":"vol.16","author":"Kato T","year":"1998","unstructured":"Kato T, Kawaguchi H, Hanada K, et al. \u201cSingle local injection of recombinant fibroblast growth factor-2 stimulates healing of segmental bone defects in rabbits\u201d J Orthop Res 1998; vol.16 : 654-9.","journal-title":"J. Orthop. Res"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1359\/jbmr.1998.13.6.942","volume":"Vol 13","author":"Nakamura T","year":"1998","unstructured":"Nakamura T, Hara Y, Tagawa M, et al. \u201cRecombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture\u201d J Bone Miner Res 1998; Vol 13 : 942-9.","journal-title":"J. Bone Miner. Res"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jor.1100170422","volume":"vol.17","author":"Radomsky ML","year":"1999","unstructured":"Radomsky ML, Aufdemorte TB, Swain LD, Fox WC, Spiro RC, Poser JW. \u201cNovel formulation of fibroblast growth factor-2 in a hyaluronan gel accelerates fracture healing in nonhuman primates\u201d J Orthop Res 1999; vol.17 : 607-14.","journal-title":"J. Orthop. Res"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3171\/jns.1999.91.5.0851","volume":"vol.91","author":"Tabata Y","year":"1999","unstructured":"Tabata Y, Yamada K, Hong L, Miyamoto S, Hashimoto N, Ikada Y. \u201cSkull bone regeneration in primates in response to basic fibroblast growth factor\u201d J Neurosurg 1999; vol.91 : 851-6.","journal-title":"J. Neurosurg"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jor.20315","volume":"vol.25","author":"Kawaguchi H","year":"2007","unstructured":"Kawaguchi H, Jingushi S, Izumi T, et al. \u201cLocal application of recombinant human fibroblast growth factor-2 on bone repair: A dose-escalation prospective trial on patients with osteotomy\u201d J Orthop Res 2007; vol.25 : 480-7.","journal-title":"J. Orthop. Res"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jbm.a.32560","volume":"vol. 93","author":"Tanaka T","year":"2010","unstructured":"Tanaka T, Saito M, Chazono M, et al. \u201cEffects of alendronate on bone formation and osteoclastic resorption of beta-tricalcium phosphate\u201d J Biomed Mater Res 2010; vol. 93 : 469-74.","journal-title":"J. Biomed. Mater. Res"}],"updated-by":[{"DOI":"10.2174\/1874120701610010001","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"record-id":"2773"}],"container-title":["The Open Biomedical Engineering Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openbiomedicalengineeringjournal.com\/contents\/volumes\/V6\/TOBEJ-6-98\/TOBEJ-6-98.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openbiomedicalengineeringjournal.com\/contents\/volumes\/V6\/TOBEJ-6-98\/TOBEJ-6-98.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openbiomedicalengineeringjournal.com\/contents\/volumes\/V6\/TOBEJ-6-98\/TOBEJ-6-98.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T08:35:51Z","timestamp":1714466151000},"score":1,"resource":{"primary":{"URL":"https:\/\/openbiomedicalengineeringjournal.com\/VOLUME\/6\/PAGE\/98\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,15]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10,15]]}},"alternative-id":["TOBEJ-6-98"],"URL":"https:\/\/doi.org\/10.2174\/1874120701206010098","relation":{},"ISSN":["1874-1207"],"issn-type":[{"value":"1874-1207","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10,15]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2012-5-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-8-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-8-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}