{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:22:27Z","timestamp":1790245347347,"version":"4.1.0"},"reference-count":24,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T00:00:00Z","timestamp":1244678400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["opencardiovascularmedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOCMJ"],"published-print":{"date-parts":[[2009,6,11]]},"abstract":"<jats:p>The atherogenic effect of cigarette smoking is already recognizable in coronary arteries of fetuses in the last gestational weeks. In this study we analyzed the atherogenic effect of mother\u2019s and father\u2019s smoking habit on coronary arteries and even on adnexa of 30 human fresh fetuses died from 32 to 41 gestational weeks. In 12 cases only the mothers of the victims were cigarette smokers, in 7 cases only the fathers were smokers, whereas in 11 cases nobody smoked.<\/jats:p>\n                <jats:p>We observed pre-atherosclerotic and initial atherosclerotic lesions of the adnexa in 21 cases, of which 11 cases had only mother smokers and 6 cases only father smokers. The atherogenic effect is statistically significant in both smoker groups, but stronger in maternal one. The atherosclerotic lesions found in umbilical and placental arteries are similar to those described in fetal coronary arteries: thickening of the arterial walls caused by proliferation and migration of the smooth muscle cells of the tunica media with loss of polarity and infiltration of the subendothelial connective tissue.<\/jats:p>","DOI":"10.2174\/1874192400903010051","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T12:43:52Z","timestamp":1245329032000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feto-Placental Atherosclerotic Lesions in Intrauterine Fetal Demise: Role of Parental Cigarette Smoking"],"prefix":"10.2174","volume":"3","author":[{"given":"D","family":"Mecchia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M","family":"Lavezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Matturri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","first-page":"74","volume":"447","author":"Matturri L","year":"2005","unstructured":"Matturri L, Ottaviani G, Lavezzi AM. \n                    Early atherosclerotic lesions in infancy: role of parental cigarette smoking \n                    Virkows Arch  \n                    2005; \n                    447\n                    : 74-80.","journal-title":"Virkows Arch"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1046\/j.1538-7836.2003.00409.x","volume":"1","author":"Matturri L","year":"2003","unstructured":"Matturri L, Lavezzi AM, Ottaviani G, Rossi L. \n                    Intimal preatherosclerotic thickening of the coronary arteries in human fetuses of smoker mothers \n                    J Thromb Haemost  \n                    2003; \n                    1\n                    : 2234-8.","journal-title":"J Thromb Haemost"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.prp.2004.03.004","volume":"200","author":"Matturri L","year":"2004","unstructured":"Matturri L, Ottaviani G, Corti G, Lavezzi AM. \n                    Pathogenesis of early atherosclerotic lesions in Infant \n                    Pathol Res Pract  \n                    2004; \n                    200\n                    : 403-10.","journal-title":"Pathol Res Pract"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.carpath.2004.05.003","volume":"13","author":"Matturri L","year":"2005","unstructured":"Matturri L, Ottaviani G, Lavezzi AM, Rossi L. \n                    Early atherosclerotic lesions of the cardiac conduction system arteries in infant \n                    Cardiovasc Pathol  \n                    2005; \n                    13\n                    : 276-81.","journal-title":"Cardiovasc Pathol"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10024-004-2020-x","volume":"7","author":"Redline RW","year":"2004","unstructured":"Redline RW, Ariel I, Boergen RN, et al. \n                    Fetal obstructive lesions: nosology and reproducibility of placental reaction patterns \n                    Pediatr Dev Pathol  \n                    2004; \n                    7\n                    : 443-52.","journal-title":"Pediatr Dev Pathol"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.29.Suppl_10.1","volume":"10","author":"Fox H","year":"1976","unstructured":"Fox H. \n                    The hystopatology of placental insufficiency \n                    J Clin Pathol Suppl (R Coll Pathol)  \n                    1976; \n                    10\n                    : 1-8.","journal-title":"J Clin Pathol Suppl (R Coll Pathol)"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0002-9149(79)90248-0","volume":"44","author":"Roberts W","year":"1979","unstructured":"Roberts W, Jones FA. \n                    Quantitation of coronary arterial narrowing at necroscopy in sudden coronary death. 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