{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:13:27Z","timestamp":1761290007635,"version":"build-2065373602"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T00:00:00Z","timestamp":1297728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["opencardiovascularmedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOCMJ"],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"\n Objective:<\/jats:title>\n The cannabinoid receptor 2 (CB2) has been implicated to play a role in various inflammatory processes. Since atherosclerosis is currently considered a chronic inflammatory disease, we studied the effect of haematopoietic CB2 deficiency on atherosclerosis development.<\/jats:p>\n <\/jats:sec>\n \n Methods and results:<\/jats:title>\n \n To investigate the effect of CB2 deficiency in immune cells on atherogenesis\n in vivo<\/jats:italic>\n , a bone marrow transplantation was performed in irradiated LDL receptor deficient mice (LDLr\n -\/-<\/jats:sup>\n ), using CB2 deficient (CB2\n -\/-<\/jats:sup>\n ) or wildtype (WT) donor mice. After 12 weeks on a high fat-high cholesterol diet, en face analysis showed that atherosclerosis in the aortic arch was significantly increased in CB2\n -\/-<\/jats:sup>\n transplanted animals (6.40 \u00b1 3.21%) as compared to WT transplanted mice (3.85 \u00b1 1.61%). Although the total lesion area in the aortic root was not significantly different between WT and CB2\n -\/-<\/jats:sup>\n transplanted mice (0.45 \u00b1 0.13 mm\n 2<\/jats:sup>\n and 0.51 \u00b1 0.17 mm\n 2<\/jats:sup>\n , respectively), CB2\n -\/-<\/jats:sup>\n transplanted mice showed a significantly larger plaque area (0.13 \u00b1 0.07 mm\n 2<\/jats:sup>\n ) than WT transplanted mice (0.08 \u00b1 0.05 mm\n 2<\/jats:sup>\n ) in the aortic valve in which atherogenesis is in an earlier stage than in the other aortic valves.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Lack of endocannabinoid signaling via the CB2 receptor aggravates early atherosclerosis development in LDLr\n -\/-<\/jats:sup>\n mice, suggesting that CB2 specific activation may prevent the development of atherosclerosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1874192401105010015","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T03:35:04Z","timestamp":1300246504000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cannabinoid Receptor 2 Deficiency in Haematopoietic cells Aggravates Early Atherosclerosis in LDL Receptor Deficient Mice"],"prefix":"10.2174","volume":"5","author":[{"given":"Dianne J.M","family":"Delsing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P","family":"Leijten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Arts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans van","family":"Eenennaam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Garritsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion J.J","family":"Gijbels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menno P.J","family":"de Winther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"van Elsas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","volume":"352","author":"Hansson GK","year":"2005","unstructured":"Hansson GK. \n Inflammation, atherosclerosis, and coronary artery disease \n N Engl J Med \n 2005; 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