{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:10:13Z","timestamp":1785809413424,"version":"3.56.0"},"reference-count":23,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:00:00Z","timestamp":1305244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["opencardiovascularmedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOCMJ"],"published-print":{"date-parts":[[2011,5,13]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Matrix metalloproteinases (MMPs) and Tissue Inhibitor of Matrix Metalloproteinases (TIMPs) may be associated with atherogenesis and plaque rupture. We evaluated the relationship between MMP-1, MMP-9, TIMP-1 and IL-6 levels and risk factors, presentation, extent and severity of atherosclerotic coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive patients who underwent coronary angiography were randomly included. The serum concentrations of MMP-1, MMP-9, TIMP-1 and IL-6 were analyzed with ELISA method in 134 patients. Participants were divided into 5 groups; stable angina pectoris (SAP; n= 34), unstable angina pectoris (USAP; n=29), non-ST elevation myocardial infarction (NSTEMI; n=16), acute ST elevation myocardial infarction (STEMI; n=25) and controls (n=30). Coronary angiographic Gensini score was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>MMP-1 levels were higher in STEMI and NSTEMI groups compared with USAP, SAP and control groups (STEMI vs USAP p=0.005; STEMI vs SAP p=0.001; STEMI vs control p&lt;0.001; NSTEMI vs USAP p=0.02; NSTEMI vs SAP p=0.027; NSTEMI vs control p&lt;0.001). In STEMI group, MMP-9 levels were higher than USAP and control groups (p=0.002; p&lt;0,001). TIMP-1 levels were not significantly different within all 5 groups. MMP-1 levels were found to be elevated in diabetic patients (p=0.020); whereas MMP-9 levels were higher in smokers (p=0.043). Higher MMP-1, MMP-9 and IL-6 levels were correlated with severe Left Anterior Descending artery (LAD) stenosis and higher angiographic Gensini Score (for severe LAD stenosis; r = 0.671, 0.363, 0.509 p&lt;0.001; for Gensini score; r = 0.717, 0.371, 0.578 p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Serum levels of MMP-1, MMP-9, and IL-6 are elevated in patients with CAD; more so in acute coronary syndromes. MMP-1, MMP-9 and IL-6 are associated with more extensive and severe CAD (as represented by Gensini score).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874192401105010110","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T01:56:23Z","timestamp":1305683783000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Relationship Between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease"],"prefix":"10.2174","volume":"5","author":[{"given":"Asli","family":"Tanindi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asife","family":"Sahinarslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehri","family":"Elbeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Cemri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7326\/0003-4819-153-6-201009210-00272","volume":"153","author":"Alsheikh-Ali AA","year":"2010","unstructured":"Alsheikh-Ali AA, Kitsios GD, Balk EM, Lau J, Ip S. \n          The vulnerable atherosclerotic plaque: scope of the literature \n          Ann Intern Med  \n          2010; \n          153\n          : 387-95.","journal-title":"Ann Intern Med"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12038-009-0035-1","volume":"34","author":"Arakaki PA","year":"2009","unstructured":"Arakaki PA, Marques MR, Santos MCLG. \n          MMP-1 polymorphism and its relationship to pathological processes \n          J Biosci  \n          2009; \n          34\n          : 313-20.","journal-title":"J Biosci"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","volume":"69","author":"Nagase H","year":"2006","unstructured":"Nagase H, Visse R, Murphy G. \n          Structure and function of matrix metalloproteinases and TIMPs \n          Cardiovasc Res  \n          2006; \n          69\n          : 562-73.","journal-title":"Cardiovasc Res"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.ATV.0000239461.87113.0b","volume":"26","author":"Choudhary S","year":"2006","unstructured":"Choudhary S, Higgins CL, Chen IY, et al. \n          Quantitation and localization of matrix metalloproteinases and their inhibitors in human carotid endarterectomy tissue \n          Arterioscler Thromb Vasc Biol  \n          2006; \n          26\n          : 2351-58.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/01.STR.0000196986.50059.e0","volume":"37","author":"Sluijter JP","year":"2006","unstructured":"Sluijter JP, Pulskens WP, Schoneveld AH, et al. \n          Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms \n          Stroke  \n          2006; \n          37\n          : 235-9.","journal-title":"Stroke"},{"key":"refR6","first-page":"215","volume":"51","author":"Amalinei C","year":"2010","unstructured":"Amalinei C, Caruntu ID, Gius\u00e7a SE, Balan RA. \n          Matrix metalloproteinases involvement in pathologic conditions \n          Rom J Morphol Embryol  \n          2010; \n          51\n          : 215-8.","journal-title":"Rom J Morphol Embryol"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cardiores.2005.11.003","volume":"69","author":"Dollery CM","year":"2006","unstructured":"Dollery CM, Libby P. \n          Atherosclerosis and proteinase activation \n          Cardiovasc Res  \n          2006; \n          69\n          : 625-35.","journal-title":"Cardiovasc Res"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cardiores.2005.08.002","volume":"69","author":"Newby AC","year":"2006","unstructured":"Newby AC. \n          Matrix metalloproteinases regulate migration, proliferation and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates \n          Cardiovasc Res  \n          2006; \n          69\n          : 614-24.","journal-title":"Cardiovasc Res"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1253\/circj.69.1180","volume":"69","author":"Higo S","year":"2005","unstructured":"Higo S, Uematsu M, Yamagishi M, et al. \n          Elevation of plasma matrix metalloproteinase-9 in the culprit coronary artery in patients with acute myocardial infarction: clinical evidence from distal protection \n          Circ J  \n          2005; \n          69\n          : 1180-5.","journal-title":"Circ J"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"A33","DOI":"10.1016\/j.jacc.2006.08.011","volume":"48","author":"Libby P","year":"2006","unstructured":"Libby P, Ridker PM. \n          Inflammation and atherosclerosis: from population biology and bench research to clinical practice \n          J Am Coll Cardiol  \n          2006; \n          48\n          : A33-46.","journal-title":"J Am Coll Cardiol"},{"key":"refR11","author":"Talukder MAH","year":"2010","unstructured":"Talukder MAH, Johnson WM, Varadharaj S, et al. \n          Chronic cigarette smoking causes hypertension, increased oxidative stres, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice \n          Am J Physiol Heart Circ Physiol \n          2010.\n          \n         doi: 10.1152\/ajpheart.00868.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1073\/pnas.0506201102","volume":"102","author":"Ohnson JL","year":"2005","unstructured":"Ohnson JL, George SJ, Newby AC, Jackson CL. \n          Divergent effects of matrix metalloproteinases 3,7,9 and 12 on atherosclerotic plaque stability in Mouse brachiocephalic arteries \n          Proc Natl Acad Sci USA  \n          2005; \n          102\n          : 15575-80.","journal-title":"Proc Natl Acad Sci USA"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000265564","volume":"47","author":"Thomas AC","year":"2010","unstructured":"Thomas AC, Newby AC. \n          Effect of matrix metalloproteinase-9 knockout on vein graft remodelling in mice \n          J Vasc Res  \n          2010; \n          47\n          : 299-308.","journal-title":"J Vasc Res"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"H987","DOI":"10.1152\/ajpheart.2001.281.3.H987","volume":"281","author":"Etoh T","year":"2001","unstructured":"Etoh T, Joffs C, Deschamps AM, et al. \n          Myocardial and interstitial matrix metalloproteinase activity after acute myocardial infarction in pigs \n          Am J Physiol Heart Circ Physiol  \n          2001; \n          281\n          : H987-94.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.amjcard.2009.10.013","volume":"105","author":"Brunner S","year":"2010","unstructured":"Brunner S, Kim JO, Methe H. \n          Relation of matrix metallo-proteinase-9\/tissue inhibitor of metalloproteinase-1 ratio in peripheral circulating CD+14 monocytes to progression of coronary artery disease \n          Am J Cardiol  \n          2010; \n          105\n          : 429-34.","journal-title":"Am J Cardiol"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/VHRM.S5789","volume":"6","author":"Palazzuoli A","year":"2010","unstructured":"Palazzuoli A, Gallotta M, Quatrini I, Nuti R. \n          Natriuretic peptides (BNP and NT-pro BNP): measurement and relevance in heart failure \n          Vasc Health Risk Manag  \n          2010; \n          6\n          : 411-8 .","journal-title":"Vasc Health Risk Manag"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1373\/49.8.1337","volume":"49","author":"Alehagen U","year":"2003","unstructured":"Alehagen U, Lindstedt G, Eriksson H, et al. \n          Utility of the amino-terminal fragment of pro-brain natriuretic peptide in plasma for the evaluation of cardiac dysfunction in elderly patients in primary health care \n          Clin Chem  \n          2003; \n          49\n          : 1337-46.","journal-title":"Clin Chem"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"61A","DOI":"10.1016\/j.amjcard.2007.11.025","volume":"101","author":"Omland T","year":"2008","unstructured":"Omland T, de Lemos JA. \n          Amino-terminal pro-B-type Natriuretic peptides in stable and unstable Ischemic heart disease \n          Am J Cardiol  \n          2008; \n          101\n          : 61A-A.","journal-title":"Am J Cardiol"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/eurheartj\/ehi038","volume":"26","author":"Jarai R","year":"2005","unstructured":"Jarai R, Iordanova N, Jarai R, et al. \n          Risk assessment in patients with unstable angina\/non-ST elevation myocardial infarction  and normal N-terminal pro-brain natriuretic peptide levels by  N-terminal pro-atrial natriuretic peptide \n          Eur Heart J  \n          2005; \n          26\n          :  250-6.","journal-title":"Eur Heart J"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.0000013290.12884.A3","volume":"90","author":"Spinale FG","year":"2002","unstructured":"Spinale FG. \n          Matrix metalloproteinases: regulation and dysregulation in the failing heart \n          Circ Res  \n          2002; \n          90\n          : 520-30.","journal-title":"Circ Res"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2009.08.073","volume":"388","author":"Yang D","year":"2009","unstructured":"Yang D, Ma S, Li D, Tang B, Yang Y. \n          Angiotensin II receptor blockade improves matrix metalloproteinases\/tissue inhibitor of matrix metalloproteinase-1 balance and restores fibronectin expression in rat infarcted myocardium \n          Biochem Biophys Res Commun  \n          2009; \n          388\n          : 66-11.","journal-title":"Biochem Biophys Res Commun"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1253\/circj.67.301","volume":"67","author":"Soejima H","year":"2003","unstructured":"Soejima H, Ogawa H, Sakamoto T, et al. \n          Increased Serum matrix metalloproteinase-1 concentration predicts Advanced Left ventricular remodelling in patients with acute myocardial infarction \n          Circ J  \n          2003; 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