{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:32:38Z","timestamp":1780806758348,"version":"3.54.1"},"reference-count":39,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:00:00Z","timestamp":1246320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":["openneurologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TONEUJ"],"published-print":{"date-parts":[[2009,6,30]]},"abstract":"<jats:p>The present study was undertaken to evaluate the possible alterations of the triangle of Guillain and Mollaret (G-Mt), a neuronal brainstem\/cerebellum network (from the dentate nucleus to red nucleus and inferior olivary nucleus) already known for its involvement in the pathogenesis of the palatal myoclonus, in sudden unexplained perinatal and infant death. In 44 cases of perinatal and infant death victims, aged from 26 gestational weeks to 10 months of life, we investigated, besides the histological morphology of the three nuclei, the c-fos and apoptotic expression, as well as the possible effects elicited by maternal cigarette smoking.<\/jats:p>\n                  <jats:p>A significant increase of lesions (hypoplasia and\/or increased c-fos and apoptotic neuronal immunopositivity) of the three nuclei was found in unexplained death victims, compared with age-matched controls. These alterations were related to maternal cigarette smoking habit.<\/jats:p>\n                  <jats:p>We postulated that the G-Mt is an important network involved in the pathogenesis of a wide spectrum of pathological manifestations and that maternal smoking during pregnancy can exert an adverse influence on this complex, even leading to sudden death in vulnerable periods of perinatal or infant development.<\/jats:p>","DOI":"10.2174\/1874205x00903010048","type":"journal-article","created":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T12:07:28Z","timestamp":1246536448000},"page":"48-53","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neuropathology of the Guillain-Mollaret Triangle (Dentato-Rubro-Olivary Network) in Sudden Unexplained Perinatal Death and SIDS"],"prefix":"10.2174","volume":"03","author":[{"given":"Anna Maria","family":"Lavezzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Corna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Matturri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/brain\/113.6.1645","volume":"113","author":"Deuschl G","year":"1990","unstructured":"Deuschl G, Mischke G, Schenck E, Schulte-M\u00f6nting J, L\u00fccking CH. \n                    Symptomatic and essential rhythmic palatal myoclonus \n                    Brain  \n                    1990; 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\n                    220\n                    : 223-30.","journal-title":"J Neurol"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1179\/016164107X166308","volume":"29","author":"Lavezzi AM","year":"2007","unstructured":"Lavezzi AM, Ottaviani G, Mauri M, Matturri L. \n                    Biopathology of the olivocerebellar network in sudden unexplained perinatal and sudden infant death syndrome related to maternal cigarette smoking \n                    Neurol Res  \n                    2007; \n                    29\n                    : 525-32.","journal-title":"Neurol Res"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0034-5687(97)00090-X","volume":"110","author":"Ackland GL","year":"1997","unstructured":"Ackland GL, Noble R, Hanson MA. \n                    Red nucleus inhibits breathing during hypoxia in neonates \n                    Respir Physiol  \n                    1997; \n                    110\n                    : 251-60.","journal-title":"Respir Physiol"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1113\/jphysiol.1996.sp021586","volume":"495","author":"Waites BA","year":"1996","unstructured":"Waites BA, Ackland GL, Noble R, Hanson MA. \n                    Red nucleus abolish the biphasic respiratory response to isocapnic hypoxia in decerebrate rabbits \n                    J Physiol  \n                    1996; 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