{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:47:09Z","timestamp":1762098429838,"version":"build-2065373602"},"reference-count":16,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openneurologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TONEUJ"],"published-print":{"date-parts":[[2012,10,5]]},"abstract":"Four federally funded randomized placebo-controlled treatment trials of post-treatment Lyme syndrome in the United States have been conducted. Most international treatment guidelines summarize these trials as having shown no acute or sustained benefit to repeated antibiotic therapy. The goal of this paper is to determine whether this summary con-clusion is supported by the evidence.<\/jats:p>\n \n Methods:<\/jats:title>\n The methods and results of the 4 U.S. treatment trials are described and their critiques evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n 2 of the 4 U.S. treatment trials demonstrated efficacy of IV ceftriaxone on primary and\/or secondary outcome measures.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Future treatment guidelines should clarify that efficacy of IV ceftriaxone for post-treatment Lyme fatigue was demonstrated in one RCT and supported by a second RCT, but that its use was not recommended primarily due to adverse events stemming from the IV route of treatment. While repeated IV antibiotic therapy can be effective, safer modes of delivery are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1874205x01206010079","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T02:06:34Z","timestamp":1350007594000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome"],"prefix":"10.2174","volume":"06","author":[{"given":"Brian A","family":"Fallon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Petkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G","family":"Keilp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn B","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","volume":"43","author":"Wormser GP","year":"2006","unstructured":"Wormser GP, Dattwyler RJ, Shapiro ED, et al. \n The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America \n Clin Infect Dis \n 2006; \n 43\n (9\n )\n : 1089-34.","journal-title":"Clin Infect Dis"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1212\/01.wnl.0000265517.66976.28","volume":"69","author":"Halperin JJ","year":"2007","unstructured":"Halperin JJ, Shapiro ED, Logigian E, et al. \n Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology \n Neurology \n 2007; \n 69\n (1\n )\n : 91-102.","journal-title":"Neurology"},{"key":"refR3","first-page":"329","volume":"65","year":"2011","unstructured":"British Infection Association. 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