{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:51:57Z","timestamp":1792709517470,"version":"4.5.0"},"reference-count":99,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openneurologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TONEUJ"],"published-print":{"date-parts":[[2012,10,5]]},"abstract":"<jats:p>\n                    With cases now documented in every province, Lyme borreliosis (LB) is emerging as a serious public health risk in Canada. Controversy over the contribution of LB to the burden of chronic disease is maintained by difficulty in capturing accurate Canadian statistics, especially early clinical cases of LB. The use of dogs as sentinel species demon-strates that potential contact with\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    spirochetes, as detected by C6 peptide, extends across the country. Dissemination of infected ticks by migratory birds and rapid establishment of significant levels of infection have been well described. Canadian public health response has focused on identification of established populations of the tick vectors,\n                    <jats:italic>Ixodes scapularis<\/jats:italic>\n                    and\n                    <jats:italic>I. pacificus<\/jats:italic>\n                    , on the assumption that these are the only important vectors of the disease across Canada. Strains of\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    circulating in Canada and the full range of their reservoir species and coinfections remain to be explored. Ongoing surveys and historical records demonstrate that\n                    <jats:italic>Borrelia<\/jats:italic>\n                    -positive\n                    <jats:italic>Ixodes<\/jats:italic>\n                    species are regu-larly present in regions of Canada that have previously been considered to be outside of the ranges of these species in re-cent modeling efforts. We present data demonstrating that human cases of LB are found across the nation. Consequently, physician education and better early diagnoses are needed to prevent long term sequelae. An international perspective will be paramount for developing improved Canadian guidelines that recognize the complexity and diversity of Lyme borreliosis.\n                  <\/jats:p>","DOI":"10.2174\/1874205x01206010094","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T02:06:34Z","timestamp":1350007594000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evolving Perspectives on Lyme Borreliosis in Canada"],"prefix":"10.2174","volume":"06","author":[{"given":"JLH","family":"Sperling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Middelveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FAH","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/pgmj.2005.037754","volume":"82","author":"Genuis SJ","year":"2006","unstructured":"Genuis SJ. \n            Dismembering the ethical physician \n            Postgrad Med J  \n            2006; \n            82\n            (966\n            )\n            : 233-8.","journal-title":"Postgrad Med J"},{"key":"refR2","unstructured":"Groopman JE. \n            How doctors think. \n            Boston: Houghton Mifflin Co 2007."},{"key":"refR3","unstructured":"Artsob H. \n            NCCID Purple Paper Canada: National Collaborating Centre for Infectious Diseases  \n            2010; \n            17."},{"key":"refR4","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1503\/cmaj.080148","volume":"180","author":"Ogden NH","year":"2009","unstructured":"Ogden NH, Lindsay LR, Morshed M, Sockett PN, Artsob H. \n            The emergence of Lyme disease in Canada \n            CMAJ  \n            2009; \n            180\n            (12\n            )\n            : 1221-4.","journal-title":"CMAJ"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4039\/n08-CPA04","volume":"141","author":"Sperling JLH","year":"2009","unstructured":"Sperling JLH, Sperling FAH. \n            Lyme borreliosis in Canada: biological diversity and diagnostic complexity from an entomological perspective \n            Can Entomol  \n            2009; \n            141\n            : 521-49.","journal-title":"Can Entomol"},{"key":"refR6","unstructured":"Association of Medical Microbiology and Infectious Disease. 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