{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:42Z","timestamp":1762004742102,"version":"3.41.0"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openneurologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TONEUJ"],"published-print":{"date-parts":[[2015,6,26]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Dilative arteriopathy plus leucencephalopathy as a manifestation of a mitochondrial disorder (MID) is rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report:<\/jats:title><jats:p>In a 70yo Caucasian female, height 160cm, weight 62kg, with mild right-sided hemiparesis due to subacute ischemic stroke in the posterior leg of the left internal capsule, a megadolichobasilar artery and marked leucencephalopathy and gliosis of the pons were detected. In addition, microbleeds in a peripheral distribution at the cortical\/subcortical border were noted. After the exclusion of various differentials, which could have explained her abnormalities, a MID was suspected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Dilative arteriopathy of the intra-cerebral arteries, in association with recurrent stroke and supra- and infratentorial leucencephalopathy, but the absence of neurofibromatosis or increased low-density lipoprotein values, is most likely attributable to a non-syndromic MID.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874205x01509010028","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T04:52:43Z","timestamp":1436503963000},"page":"28-31","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dilative Arteriopathy and Leucencephalopathy as Manifestations of a Neurometabolic Disease"],"prefix":"10.2174","volume":"9","author":[{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Bastovansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2176\/nmc.35.104","volume":"35","author":"Aiba T","year":"1995","unstructured":"Aiba T, Nakazawa T. Non-communicating hydrocephalus due to megadolichobasilar artery--case report Neurol Med Chir (Tokyo) 1995; 35 : 104-6.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1054\/jocn.2001.0991","volume":"9","author":"Byrne E","year":"2002","unstructured":"Byrne E. Does mitochondrial respiratory chain dysfunction have a role in common neurodegenerative disorders\u03ba J Clin Neurosci 2002; 9 : 497-501.","journal-title":"J Clin Neurosci"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jamaneurol.2013.618","volume":"70","author":"Cambron M","year":"2013","unstructured":"Cambron M, Van Hooff RJ, Nieboer K, De Keyser J, Brouns R. Successful repetitive intravenous thrombolysis in a patient with recurrent brainstem infarctions due to megadolichobasilar ectasia JAMA Neurol 2013; 70 : 520-1.","journal-title":"JAMA Neurol"},{"key":"refR4","first-page":"332","volume":"82","author":"Campos E","year":"1984","unstructured":"Campos E, Mat\u00edas-Gu\u00edu J, Romero F, Fern\u00e1ndez JM, D\u00e1valos A. Megadolichobasilar presentation as facial hemispasm Med Clin (Barc) 1984; 82 : 332.","journal-title":"Med Clin (Barc)"},{"key":"refR5","first-page":"611","volume":"14","author":"D'Andrea F","year":"1992","unstructured":"D'Andrea F, Maiuri F, Gangemi M, Iaconetta G. Megadolichobasilar anomaly.Clinical and diagnostic considerations on 30 cases. Acta Neurol (Napoli) 1992; 14 : 611-9.","journal-title":"Acta Neurol (Napoli)"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s13760-012-0009-1","volume":"112","author":"Finsterer J","year":"2012","unstructured":"Finsterer J. Dilative arteriopathy in metabolic myopathies, particularly Pompe's disease Acta Neurol Belg 2012; 112 : 15-8.","journal-title":"Acta Neurol Belg"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.numecd.2012.01.002","volume":"22","author":"Finsterer J","year":"2012","unstructured":"Finsterer J, Mahjoub SZ. Primary mitochondrial arteriopathy Nutr Metab Cardiovasc Dis 2012; 22 : 393-9.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/brain\/awh546","volume":"128","author":"Garzuly F","year":"2005","unstructured":"Garzuly F, Mar\u00f3di L, Erd\u00f6s M, et al. Megadolichobasilar anomaly with thrombosis in a family with Fabry's disease and a novel mutation in the alpha-galactosidase A gene Brain 2005; 128 : 2078-83.","journal-title":"Brain"},{"key":"refR9","first-page":"337","volume":"48","author":"Guiral H","year":"1997","unstructured":"Guiral H, Risco J, Ferrer F. Otoneurological manifestations of basilar dolicoectasia A report of six cases Acta Otorrinolaringol Esp 1997; 48 : 337-40.","journal-title":"A report of six cases. Acta Otorrinolaringol Esp"},{"key":"refR10","first-page":"pii: S1052","volume":"doi","author":"Heckmann JG","year":"2013","unstructured":"Heckmann JG, Ernst S. Central Alveolar Hypoventilation (Ondine's Curse) Caused by Megadolichobasilar Artery J Stroke Cerebrovasc Dis 2013; doi : pii: S1052-.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.07.002","volume":"21","author":"Ichikawa H","year":"2012","unstructured":"Ichikawa H, Mukai M, Ohno H, Shimizu Y, Itaya K, Kawamura M. Dee white matter hyperintensities, decreased serum low-density lipoprotein, and dilative large arteriopathy J Stroke Cerebrovasc Dis 2012; 21 : 225-30.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.01.011","volume":"18","author":"Ichikawa H","year":"2009","unstructured":"Ichikawa H, Takahashi N, Mukai M, Katoh H, Akizawa T, Kawamura M. Intracranial dilative arteriopathy is associated with chronic kidney disease and small vessel diseases in the elderly J Stroke Cerebrovasc Dis 2009; 18 : 435-2.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"refR13","first-page":"359","volume":"44","author":"Ishikawa T","year":"2004","unstructured":"Ishikawa T, Nagayama M, Iida M, Shinohara Y. Bulbovascular compression by megadolichobasilar artery manifested as neurogenic and refractory hypertension Rinsho Shinkeigaku 2004; 44 : 359-64.","journal-title":"Rinsho Shinkeigaku"},{"key":"refR14","first-page":"707","volume":"44","author":"Ikeda K","year":"2004","unstructured":"Ikeda K, Iwasaki Y. Megadolichobasilar artery and neurogenic hypertension Rinsho Shinkeigaku 2004; 44 : 707-10.","journal-title":"Rinsho Shinkeigaku"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00383269","volume":"14","author":"Klinge H","year":"1991","unstructured":"Klinge H, Braunsdorf WE. Clinical signs associated with megadolichobasilar artery anomaly Neurosurg Rev 1991; 14 : 303-7.","journal-title":"Neurosurg Rev"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0303-8467(03)00045-3","volume":"106","author":"Krasnianski M","year":"2003","unstructured":"Krasnianski M, Gaul C, Neudecker S, Behrmann C, Schl\u00fcter A, Winterholler M. Yawning despite trismus in a patient with locked-in syndrome caused by a thrombosed megadolichobasilar artery Clin Neurol Neurosurg 2003; 106 : 44-6.","journal-title":"Clin Neurol Neurosurg"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/01.wnl.0000313367.09469.13","volume":"70","author":"Lafor\u00eat P","year":"2008","unstructured":"Lafor\u00eat P, Petiot P, Nicolino M, et al. Dilative arteriopathy and basilar artery dolichoectasia complicating late-onset Pompe disease Neurology 2008; 70 : 2063-6.","journal-title":"Neurology"},{"key":"refR18","first-page":"310","volume":"5","author":"Lemke AJ","year":"1995","unstructured":"Lemke AJ, Sander B, Benndorf G, et al. Megadolichobasilar artery as a rare cause of hydrocephalus internus synopsis of modern imaging methods Aktuelle Radiol 1995; 5 : 310-4.","journal-title":"Aktuelle Radiol"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ana.410400105","volume":"40","author":"Mitsias P","year":"1996","unstructured":"Mitsias P, Levine SR. Cerebrovascular complications of Fabry's disease Ann Neurol 1996; 40 : 8-17.","journal-title":"Ann Neurol"},{"key":"refR20","first-page":"1395","volume":"29","author":"Okabe S","year":"1989","unstructured":"Okabe S, Oda N, Ishii M. Agenesis of left internal carotid artery associated with megadolichobasilar anomaly and olivopontocerebellar atrophy Rinsho Shinkeigaku 1989; 29 : 1395-400.","journal-title":"Rinsho Shinkeigaku"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s001060050411","volume":"47","author":"Otterstedde CR","year":"1999","unstructured":"Otterstedde CR, Tischendorf M, Reisser C. Megadolichobasilar artery as the etiology of sensorineural deafness in differential sudden deafness diagnosis HNO 1999; 47 : 494-6.","journal-title":"HNO"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00115-007-2263-7","volume":"78","author":"Roth C","year":"2007","unstructured":"Roth C, Gaiser T, Nagelmeier I, R\u00fcschoff J, Ferbert A. Type I neurofibromatosis and megadolichobasilar artery Nervenarzt 2007; 78 : 1195-9.","journal-title":"Nervenarzt"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"638","DOI":"10.33588\/rn.4110.2005367","volume":"41","author":"Santos-Garcia D","year":"2005","unstructured":"Santos-Garcia D, Prieto JM, Blanco-Gonzalez M, Iglesias-Gomez S, Rodriguez-Constenla I, Lema M. SUNCT syndrome secondary to megadolichobasilar anomaly Rev Neurol 2005; 41 : 638-9.","journal-title":"Rev Neurol"},{"key":"refR24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0149-936X(85)90055-4","volume":"9","author":"Shirakuni T","year":"1985","unstructured":"Shirakuni T, Tamaki N, Matsumoto S, Fujiwara M. Megadolichobasilar anomaly associated with brain stem infarction a case report J Comput Tomogr 1985; 9 : 79-81.","journal-title":"J Comput Tomogr"},{"key":"refR25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/BF02336569","volume":"11","author":"Uncini A","year":"1990","unstructured":"Uncini A, Lugaresi A, Porrini AM, Gallucci M. Recurrent cranial nerve palsies, midbrain infarction and hydrocephalus due to megadolichobasilar artery Ital J Neurol Sci 1990; 11 : 489-92.","journal-title":"Ital J Neurol Sci"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00106-006-1498-0","volume":"56","author":"Unkelbach MH","year":"2008","unstructured":"Unkelbach MH, Radeloff A, Bink A, Gst\u00f6ttner W, Ziemann U. Megadolichobasilar anomaly causing acute deafness with vertigo HNO 2008; 56 : 62-4.","journal-title":"HNO"},{"key":"refR27","first-page":"1235","volume":"60","author":"Uyama E","year":"2008","unstructured":"Uyama E. Fabry disease in light of recent review Brain Nerve 2008; 60 : 1235-44.","journal-title":"Brain Nerve"},{"key":"refR28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1620\/tjem.172.327","volume":"172","author":"Yoshida M","year":"1994","unstructured":"Yoshida M, Asano M. Direct compression by megadolichobasilar anomaly as a cause of trigeminal neuralgia; a case diagnosed by MRI Tohoku J Exp Med 1994; 172 : 327-.","journal-title":"Tohoku J Exp Med"},{"key":"refR29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1179\/016164110X12670144526345","volume":"32","author":"Zhang ZQ","year":"2010","unstructured":"Zhang ZQ, Niu ST, Liang XH, Jian F, Wang Y. Vascular involvement in the pathogenesis of mitochondrial encephalo-myopathies Neurol Res 2010; 32 : 403-8.","journal-title":"Neurol Res"}],"container-title":["The Open Neurology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openneurologyjournal.com\/contents\/volumes\/V9\/TONEUJ-9-28\/TONEUJ-9-28.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openneurologyjournal.com\/contents\/volumes\/V9\/TONEUJ-9-28\/TONEUJ-9-28.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openneurologyjournal.com\/contents\/volumes\/V9\/TONEUJ-9-28\/TONEUJ-9-28.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:33:13Z","timestamp":1748489593000},"score":1,"resource":{"primary":{"URL":"https:\/\/openneurologyjournal.com\/VOLUME\/9\/PAGE\/28\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,6,26]]}},"alternative-id":["TONEUJ-9-28"],"URL":"https:\/\/doi.org\/10.2174\/1874205x01509010028","relation":{},"ISSN":["1874-205X"],"issn-type":[{"type":"print","value":"1874-205X"}],"subject":[],"published":{"date-parts":[[2015,6,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2014-1-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-3-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-3-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-6-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}