{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:30:06Z","timestamp":1777120206966,"version":"3.51.4"},"reference-count":41,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2009,9,7]],"date-time":"2009-09-07T00:00:00Z","timestamp":1252281600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["opendentistryjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TODENTJ"],"published-print":{"date-parts":[[2009,9,7]]},"abstract":"<jats:p>IL-10 and TNF-\u03b1 are cytokines that have complex and opposing roles in the inflammatory responses. G\/A polymorphisms at position \u20131082 of<jats:italic>IL10<\/jats:italic>and \u2013308 of<jats:italic>TNFA<\/jats:italic>genes have been reported to influence the expression of IL-10 and TNF-\u03b1, respectively. The aim of this study was to investigate the association between the<jats:italic>IL10<\/jats:italic>(-1082) and<jats:italic>TNFA<\/jats:italic>(- 308) gene polymorphisms with different clinical forms or severity of periodontitis in a sample of Brazilian individuals. DNA was obtained from oral swabs of 165 Brazilian individuals, which were divided into three groups: individuals with chronic periodontitis, aggressive periodontitis and individuals without clinical evidence of periodontitis. Evaluation of<jats:italic>IL10<\/jats:italic>and<jats:italic>TNFA<\/jats:italic>polymorphisms was performed by RFLP analysis. Statistical analysis of data was performed using the \u03c7<jats:sup>2<\/jats:sup>likelihood ratio and Fisher`s exact test. No significant differences in the genotype and allele distribution of either<jats:italic>IL10<\/jats:italic>or<jats:italic>TNFA<\/jats:italic>were observed among individuals with different clinical forms or with different degrees of severity of periodontitis. Moreover, combined analysis of<jats:italic>IL10<\/jats:italic>and<jats:italic>TNFA<\/jats:italic>polymorphisms did not show any association with periodontal status. As conclusion, the<jats:italic>IL10<\/jats:italic>and<jats:italic>TNFA<\/jats:italic>gene promoter polymorphisms investigated are not associated with different clinical forms of periodontitis or with severity of the disease in the Brazilian population polymorphisms.<\/jats:p>","DOI":"10.2174\/1874210600903010184","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T12:51:54Z","timestamp":1252673514000},"page":"184-190","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["TNFA and IL10 Gene Polymorphisms are not Associated with Periodontitis in Brazilians"],"prefix":"10.2174","volume":"3","author":[{"given":"P. R","family":"Moreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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