{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:33:16Z","timestamp":1793316796182,"version":"4.5.0"},"reference-count":40,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":["opendentistryjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TODENTJ"],"published-print":{"date-parts":[[2016,7,29]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation defects in beagle dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Collagen hydrogel was fabricated from bovine type I collagen with an ascorbate-copper ion cross-linking system. Collagen hydrogel was mingled with FGF2 and injected into sponge-form collagen. Subsequently, FGF2 (50 \u00b5g)\/collagen hydrogel scaffold and collagen hydrogel scaffold alone were implanted into class II furcation defects in dogs. In addition, no implantation was performed as a control. Histometric parameters were assessed at 10 days and 4 weeks after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result:<\/jats:title><jats:p>FGF2 application to scaffold promoted considerable cell and tissue ingrowth containing numerous cells and blood vessel-like structure at day 10. At 4 weeks, reconstruction of alveolar bone was stimulated by implantation of scaffold loaded with FGF2. Furthermore, periodontal attachment, consisting of cementum-like tissue, periodontal ligament-like tissue and Sharpey\u2019s fibers, was also repaired, indicating that FGF2-loaded scaffold guided self-assembly and then re-established the function of periodontal organs. Aberrant healing, such as ankylosis and root resorption, was not observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>FGF2-loaded collagen hydrogel scaffold possessed excellent biocompatibility and strongly promoted periodontal tissue engineering, including periodontal attachment re-organization.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874210601610010347","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T04:32:39Z","timestamp":1470198759000},"page":"347-359","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog"],"prefix":"10.2174","volume":"10","author":[{"given":"Takehito","family":"Momose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Miyaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syusuke","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Kawanami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1097\/SCS.0000000000000830","volume":"25","author":"Cicci\u00f9 M.","year":"2014","unstructured":"Cicci\u00f9 M, Herford AS, Cicci\u00f9 D, Tandon R, Maiorana C. Recombinant human bone morphogenetic protein-2 promote and stabilize hard and soft tissue healing for large mandibular new bone reconstruction defects. J Craniofac Surg 2014; 25 (3) : 860-2.","journal-title":"J. Craniofac. Surg."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/452750","volume":"2013","author":"Petrauskaite O","year":"2013","unstructured":"Petrauskaite O, Gomes Pde S, Fernandes MH, et al. Biomimetic mineralization on a macroporous cellulose-based matrix for bone regeneration. Biomed Res Int 2013; 2013 : 1-9. (Article ID 452750)","journal-title":"Biomed Res Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2174\/1874210601105010071","volume":"5","author":"Maiorana C.","year":"2011","unstructured":"Maiorana C, Beretta M, Battista Grossi G, et al. Histomorphometric evaluation of anorganic bovine bone coverage to reduce autogenous grafts resorption: preliminary results. Open Dent J 2011; 5 : 71-8.","journal-title":"Open Dent. J."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.4317\/medoral.16.e115","volume":"16","author":"Park J.B.","year":"2011","unstructured":"Park JB. The use of hydrogels in bone-tissue engineering. Med Oral Patol Oral Cir Bucal 2011; 16 (1) : e115-8.","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s10856-005-0526-z","volume":"16","author":"Barralet J.E.","year":"2005","unstructured":"Barralet JE, Wang L, Lawson M, Triffitt JT, Cooper PR, Shelton RM. Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels. J Mater Sci Mater Med 2005; 16 (6) : 515-9.","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s10856-006-0615-7","volume":"17","author":"Cui F.Z.","year":"2006","unstructured":"Cui FZ, Tian WM, Hou SP, Xu QY, Lee IS. Hyaluronic acid hydrogel immobilized with RGD peptides for brain tissue engineering. J Mater Sci Mater Med 2006; 17 (12) : 1393-401.","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/jbm.a.30837","volume":"79","author":"Hong Y.","year":"2006","unstructured":"Hong Y, Mao Z, Wang H, Gao C, Shen J. Covalently crosslinked chitosan hydrogel formed at neutral pH and body temperature. J Biomed Mater Res A 2006; 79 (4) : 913-22.","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jbm.a.32696","volume":"94","author":"Hesse E.","year":"2010","unstructured":"Hesse E, Hefferan TE, Tarara JE, et al. Collagen type I hydrogel allows migration, proliferation, and osteogenic differentiation of rat bone marrow stromal cells. J Biomed Mater Res A 2010; 94 (2) : 442-9.","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1097\/SAP.0b013e31819b6c52","volume":"64","author":"Asamura S.","year":"2010","unstructured":"Asamura S, Mochizuki Y, Yamamoto M, Tabata Y, Isogai N. Bone regeneration using a bone morphogenetic protein-2 saturated slow-release gelatin hydrogel sheet: evaluation in a canine orbital floor fracture model. Ann Plast Surg 2010; 64 (4) : 496-502.","journal-title":"Ann. Plast. Surg."},{"key":"ref10","first-page":"791","volume":"26","author":"Ishikawa K.","year":"1997","unstructured":"Ishikawa K, Matsui R, Takano Y, Katakura T. Preparation of biodegradable hydrogel. Jpn J Artif Organs 1997; 26 : 791-7.","journal-title":"Jpn J Artif Organs"},{"key":"ref11","first-page":"772","volume":"26","author":"Matsui R.","year":"1997","unstructured":"Matsui R, Ishikawa K, Takano Y, Katakura T. Application of collagen hydrogel material onto model delayed closing of full-thickness skin defect wound on guinea-pig. Jpn J Artif Organs 1997; 26 : 772-8.","journal-title":"Jpn J Artif Organs"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1600-0765.2012.01475.x","volume":"47","author":"Kosen Y.","year":"2012","unstructured":"Kosen Y, Miyaji H, Kato A, Sugaya T, Kawanami M. Application of collagen hydrogel\/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs. J Periodontal Res 2012; 47 (5) : 626-34.","journal-title":"J. Periodontal Res."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1874210601509010052","volume":"9","author":"Kato A.","year":"2015","unstructured":"Kato A, Miyaji H, Ishizuka R, et al. Combination of root surface modification with BMP-2 and collagen hydrogel scaffold implantation for periodontal healing in beagle dogs. Open Dent J 2015; 9 : 52-9.","journal-title":"Open Dent. J."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.bone.2008.12.017","volume":"44","author":"Kodama N.","year":"2009","unstructured":"Kodama N, Nagata M, Tabata Y, Ozeki M, Ninomiya T, Takagi R. A local bone anabolic effect of rhFGF2-impregnated gelatin hydrogel by promoting cell proliferation and coordinating osteoblastic differentiation. Bone 2009; 44 (4) : 699-707.","journal-title":"Bone"},{"key":"ref15","first-page":"1","volume":"1","author":"Yun YR","year":"2010","unstructured":"Yun YR, Won JE, Jeon E, et al. Fibroblast growth factors: biology, function, and application for tissue regeneration. J Tissue Eng 2010; 1 : 1-18. (Article ID 218142)","journal-title":"J Tissue Eng"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1056\/NEJM199909023411006","volume":"341","author":"Singer A.J.","year":"1999","unstructured":"Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341 (10) : 738-46.","journal-title":"N. Engl. J. Med."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1210\/endo.138.10.5425","volume":"138","author":"Martin I.","year":"1997","unstructured":"Martin I, Muraglia A, Campanile G, Cancedda R, Quarto R. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 1997; 138 (10) : 4456-62.","journal-title":"Endocrinology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S8756-3282(99)00252-5","volume":"26","author":"Zellin G.","year":"2000","unstructured":"Zellin G, Linde A. Effects of recombinant human fibroblast growth factor-2 on osteogenic cell populations during orthopic osteogenesis in vivo.. Bone 2000; 26 (2) : 161-8.","journal-title":"Bone"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1034\/j.1600-0765.2003.00640.x","volume":"38","author":"Murakami S","year":"2003","unstructured":"Murakami S, Takayama S, Kitamura M, et al. Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs. J Periodont Res 2003; 38 : 97-103.","journal-title":"J Periodont Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1177\/00220345010800121001","volume":"80","author":"Takayama S.","year":"2001","unstructured":"Takayama S, Murakami S, Shimabukuro Y, Kitamura M, Okada H. Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res 2001; 80 (12) : 2075-9.","journal-title":"J. Dent. Res."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/639502","volume":"2013","author":"Ibara A","year":"2013","unstructured":"Ibara A, Miyaji H, Fugetsu B, et al. Osteoconductivity and biodegradability of collagen scaffold coated with nano-\u03b2-TCP and fibroblast growth factor 2. J Nanomater 2013; 2013 : 1-11. (Article ID 639502)","journal-title":"J Nanomater"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1902\/jop.2012.120307","volume":"84","author":"Kim Y.T.","year":"2013","unstructured":"Kim YT, Wikesj\u00f6 UM, Jung UW, Lee JS, Kim TG, Kim CK. Comparison between a \u03b2-tricalcium phosphate and an absorbable collagen sponge carrier technology for rhGDF-5-stimulated periodontal wound healing\/regeneration. J Periodontol 2013; 84 (6) : 812-20.","journal-title":"J. Periodontol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/249123a0","volume":"249","author":"Gospodarowicz D.","year":"1974","unstructured":"Gospodarowicz D. Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 1974; 249 (453) : 123-7.","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1046\/j.1523-1755.2000.00997.x","volume":"57","author":"Strutz F.","year":"2000","unstructured":"Strutz F, Zeisberg M, Hemmerlein B, et al. Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int 2000; 57 (4) : 1521-38.","journal-title":"Kidney Int."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1359\/jbmr.1998.13.4.645","volume":"13","author":"Debiais F.","year":"1998","unstructured":"Debiais F, Hott M, Graulet AM, Marie PJ. The effects of fibroblast growth factor-2 on human neonatal calvaria osteoblastic cells are differentiation stage specific. J Bone Miner Res 1998; 13 (4) : 645-54.","journal-title":"J. Bone Miner. Res."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.archoralbio.2006.07.007","volume":"52","author":"Donzelli E.","year":"2007","unstructured":"Donzelli E, Salvad\u00e8 A, Mimo P, et al. Mesenchymal stem cells cultured on a collagen scaffold: In vitro osteogenic differentiation. Arch Oral Biol 2007; 52 (1) : 64-73.","journal-title":"Arch. Oral Biol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/BF02634001","volume":"31","author":"Talley-Ronsholdt D.J.","year":"1995","unstructured":"Talley-Ronsholdt DJ, Lajiness E, Nagodawithana K. Transforming growth factor-beta inhibition of mineralization by neonatal rat osteoblasts in monolayer and collagen gel culture. In Vitro Cell Dev Biol Anim 1995; 31 (4) : 274-82.","journal-title":"Cell. Dev. Biol. Anim."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.ph.53.030191.001245","volume":"53","author":"Klagsbrun M.","year":"1991","unstructured":"Klagsbrun M, D\u2019Amore PA. Regulators of angiogenesis. Annu Rev Physiol 1991; 53 : 217-39.","journal-title":"Annu. Rev. Physiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/0022034513511640","volume":"93","author":"Yanagita M.","year":"2014","unstructured":"Yanagita M, Kojima Y, Kubota M, et al. Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells. J Dent Res 2014; 93 (1) : 89-95.","journal-title":"J. Dent. Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1034\/j.1600-0757.2000.2220104.x","volume":"22","author":"Aukhil I.","year":"2000","unstructured":"Aukhil I. Biology of wound healing. Periodontol 2000 2000; 22 (22) : 44-50.","journal-title":"Periodontol. 2000"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1054\/bjom.2001.0647","volume":"39","author":"Fujimura K.","year":"2001","unstructured":"Fujimura K, Bessho K, Kusumoto K, Konishi Y, Ogawa Y, Iizuka T. Experimental osteoinduction by recombinant human bone morphogeneticprotein 2 in tissue with low blood flow: a study in rats. Br J Oral Maxillofac Surg 2001; 39 (4) : 294-300.","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.archoralbio.2011.12.003","volume":"57","author":"Hidaka T.","year":"2012","unstructured":"Hidaka T, Nagasawa T, Shirai K, Kado T, Furuichi Y. FGF-2 induces proliferation of human periodontal ligament cells and maintains differentiation potentials of STRO-1(+)\/CD146(+) periodontal ligament cells. Arch Oral Biol 2012; 57 (6) : 830-40.","journal-title":"Arch. Oral Biol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1097\/SCS.0b013e318292c2ce","volume":"24","author":"Herford A.S.","year":"2013","unstructured":"Herford AS, Tandon R, Stevens TW, Stoffella E, Cicciu M. Immediate distraction osteogenesis: the sandwich technique in combination with rhBMP-2 for anterior maxillary and mandibular defects. J Craniofac Surg 2013; 24 (4) : 1383-7.","journal-title":"J. Craniofac. Surg."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1097\/SCS.0b013e31824dbdd4","volume":"23","author":"Cicci\u00f9 M.","year":"2012","unstructured":"Cicci\u00f9 M, Herford AS, Juod\u017ebalys G, Stoffella E. Recombinant human bone morphogenetic protein type 2 application for a possible treatment of bisphosphonates-related osteonecrosis of the jaw. J Craniofac Surg 2012; 23 (3) : 784-8.","journal-title":"J. Craniofac. Surg."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1097\/SCS.0b013e3181f502fa","volume":"21","author":"Herford A.S.","year":"2010","unstructured":"Herford AS, Cicci\u00f9 M. Recombinant human bone morphogenetic protein type 2 jaw reconstruction in patients affected by giant cell tumor. J Craniofac Surg 2010; 21 (6) : 1970-5.","journal-title":"J. Craniofac. Surg."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/oxfordjournals.jbchem.a122123","volume":"102","author":"Kano Y.","year":"1987","unstructured":"Kano Y, Sakano Y, Fujimoto D. Cross-linking of collagen by ascorbate-copper ion systems. J Biochem 1987; 102 (4) : 839-42.","journal-title":"J. Biochem."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1054\/bjps.2000.3426","volume":"53","author":"Suzuki S.","year":"2000","unstructured":"Suzuki S, Kawai K, Ashoori F, Morimoto N, Nishimura Y, Ikada Y. Long-term follow-up study of artificial dermis composed of outer silicone layer and inner collagen sponge. Br J Plast Surg 2000; 53 (8) : 659-66.","journal-title":"Br. J. Plast. Surg."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0007-1226(92)90170-3","volume":"45","author":"Abramo A.C.","year":"1992","unstructured":"Abramo AC, Viola JC. Heterologous collagen matrix sponge: histologic and clinical response to its implantation in third-degree burn injuries. Br J Plast Surg 1992; 45 (2) : 117-22.","journal-title":"Br. J. Plast. Surg."},{"key":"ref39","first-page":"ZC52","volume":"8","author":"D\u2019lima J.P.","year":"2014","unstructured":"D\u2019lima JP, Paul J, Palathingal P, Varma B, Bhat M, Mohanty M. Histological and histometrical evaluation of two synthetic hydroxyapatite based biomaterials in the experimental periodontal defects in dogs. J Clin Diagn Res 2014; 8 (9) : ZC52-5.","journal-title":"J. Clin. Diagn. Res."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/0142-9612(96)84674-6","volume":"17","author":"Matsui R.","year":"1996","unstructured":"Matsui R, Okura N, Osaki K, Konishi J, Ikegami K, Koide M. Histological evaluation of skin reconstruction using artificial dermis. Biomaterials 1996; 17 (10) : 995-1000.","journal-title":"Biomaterials"}],"container-title":["The Open Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opendentistryjournal.com\/contents\/volumes\/V10\/TODENTJ-10-347\/TODENTJ-10-347.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/opendentistryjournal.com\/contents\/volumes\/V10\/TODENTJ-10-347\/TODENTJ-10-347.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/opendentistryjournal.com\/contents\/volumes\/V10\/TODENTJ-10-347\/TODENTJ-10-347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T17:16:03Z","timestamp":1718730963000},"score":1,"resource":{"primary":{"URL":"https:\/\/opendentistryjournal.com\/VOLUME\/10\/PAGE\/347\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,29]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7,29]]}},"alternative-id":["TODENTJ-10-347"],"URL":"https:\/\/doi.org\/10.2174\/1874210601610010347","relation":{},"ISSN":["1874-2106"],"issn-type":[{"value":"1874-2106","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2015-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-6-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-6-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}