{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:51:21Z","timestamp":1791888681596,"version":"4.3.4"},"reference-count":21,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["opendentistryjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TODENTJ"],"published-print":{"date-parts":[[2016,8,31]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Local anaesthetics play a key role in reducing pain and anxiety during dental treatment. However the disadvantage of using syringe and needle technique in the maxilla, proximal to the apices of the teeth is that it is painful and also leads to collateral anaesthesia. Hence this systematic review aims to identify whether computer assisted local anaesthetic delivery system could produce predictable results similar to conventional syringe needle technique and also eliminate the disadvantages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>Electronic databases were searched for eligible studies. A pre-tested data extraction form was created and following data were extracted from each eligible study: trial site, year, trial methods, participants, interventions and outcomes. A significant heterogeneity was seen in between the eligible studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Six studies met the inclusion criteria and were included in the present review. One was cross-over and one split mouth, while others were parallel. Only one was open label and the rest were single blinded. Three studies were conducted in children while the rest in adults. The outcome measurement was directed to measure psychological attributes using visual analog scale, electric pulp testing and pain behaviour code.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Unfortunately because of the clinical heterogeneity, meta-analysis could not be performed. Hence it is difficult to conclude that the computer assisted delivery is better than the conventional method, although it was found to perform better. Many high quality studies assessing the efficacy and cost-efficiency of various modes of administration are required to confirm the utility of computer assisted delivery systems.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874210601610010454","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T11:07:04Z","timestamp":1472814424000},"page":"454-459","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Local Anaesthetic Drug Administration in Dentistry Using Computer Assisted Anaesthetic Delivery System: A Systematic Review"],"prefix":"10.2174","volume":"10","author":[{"given":"Gowri","family":"Sivaramakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Sridharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","first-page":"138","volume":"51","author":"Bahl R.","year":"2004","unstructured":"Bahl R. Local anesthesia in dentistry. Anesth Prog 2004; 51 (4) : 138-42.","journal-title":"Anesth. Prog."},{"key":"ref2","first-page":"546","volume":"68","author":"Haas D.A.","year":"2002","unstructured":"Haas DA. An update on local anesthetics in dentistry. J Can Dent Assoc 2002; 68 (9) : 546-51.","journal-title":"J. Can. Dent. Assoc."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Yagiela JA. Local anesthetics. In: Dionne RA, Phero JC, Becker DE, Eds. Pain and anxiety control in dentistry. Philadelphia: W. B. Saunders 2002; pp. 78-96.","DOI":"10.1016\/B0-7216-7278-7\/50010-1"},{"key":"ref4","unstructured":"Haas DA. Drugs in dentistry. In: Compendium of pharmaceuticals and specialties (CPS). 37th ed. Canada: Canadian Pharmaceutical Association 2002; pp. L26-9."},{"key":"ref5","unstructured":"United States Pharmacopeial Drug Information Index. Greenwood Village. 22nd ed. Colorado: Micromedex 2002."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.14219\/jada.archive.1999.0280","volume":"130","author":"Yagiela J.A.","year":"1999","unstructured":"Yagiela JA. Adverse drug interactions in dental practice: interactions associated with vasoconstrictors. Part V of a series. J Am Dent Assoc 1999; 130 (5) : 701-9.","journal-title":"J. Am. Dent. Assoc."},{"key":"ref7","first-page":"297","volume":"29","author":"Friedman M.J.","year":"1998","unstructured":"Friedman MJ, Hochman MN. The AMSA injection: a new concept for local anesthesia of maxillary teeth using a computer-controlled injection system. Quintessence Int 1998; 29 (5) : 297-303.","journal-title":"Quintessence Int."},{"key":"ref8","first-page":"247","volume":"27","author":"Ran D.","year":"2003","unstructured":"Ran D, Peretz B. Assessing the pain reaction of children receiving periodontal ligament anesthesia using a computerized device (Wand). J Clin Pediatr Dent 2003; 27 (3) : 247-50.","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.tripleo.2004.11.009","volume":"99","author":"Berlin J.","year":"2005","unstructured":"Berlin J, Nusstein J, Reader A, Beck M, Weaver J. Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99 (3) : 361-6.","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref10","unstructured":"Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. Version. 5.1.0, 2015 Available from: www.cochrane-handbook.org [Accessed on 15 Oct 2015]."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","volume":"62","author":"Moher D.","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62 (10) : 1006-12.","journal-title":"J. Clin. Epidemiol."},{"key":"ref12","first-page":"119","volume":"72","author":"Klein U.","year":"2005","unstructured":"Klein U, Hunzeker C, Hutfless S, Galloway A. Quality of anesthesia for the maxillary primary anterior segment in pediatric patients: comparison of the P-ASA nerve block using CompuMed delivery system vs traditional supraperiosteal injections. J Dent Child (Chic) 2005; 72 (3) : 119-25.","journal-title":"J. Dent. Child. (Chic.)"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.14219\/jada.archive.2004.0188","volume":"135","author":"Loomer P.M.","year":"2004","unstructured":"Loomer PM, Perry DA. Computer-controlled delivery versus syringe delivery of local anesthetic injections for therapeutic scaling and root planing. J Am Dent Assoc 2004; 135 (3) : 358-65.","journal-title":"J. Am. Dent. Assoc."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1590\/S1678-77572009000500012","volume":"17","author":"Yenisey M.","year":"2009","unstructured":"Yenisey M. Comparison of the pain levels of computer-controlled and conventional anesthesia techniques in prosthodontic treatment. J Appl Oral Sci 2009; 17 (5) : 414-20.","journal-title":"J. Appl. Oral Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/BF03321604","volume":"10","author":"Tahmassebi J.F.","year":"2009","unstructured":"Tahmassebi JF, Nikolaou M, Duggal MS. A comparison of pain and anxiety associated with the administration of maxillary local analgesia with Wand and conventional technique. Eur Arch Paediatr Dent 2009; 10 (2) : 77-82.","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.1038\/sj.bdj.2012.988","volume":"213","author":"Kandiah P.","year":"2012","unstructured":"Kandiah P, Tahmassebi JF. Comparing the onset of maxillary infiltration local anaesthesia and pain experience using the conventional technique vs. the Wand in children. Br Dent J 2012; 213 (9) : E15.","journal-title":"Br. Dent. J."},{"key":"ref17","first-page":"315","volume":"24","author":"Allen K.D.","year":"2002","unstructured":"Allen KD, Kotil D, Larzelere RE, Hutfless S, Beiraghi S. Comparison of a computerized anesthesia device with a traditional syringe in preschool children. Pediatr Dent 2002; 24 (4) : 315-20.","journal-title":"Pediatr. Dent."},{"key":"ref18","first-page":"216","volume":"55","author":"Flanagan T.","year":"2007","unstructured":"Flanagan T, Wahl MJ, Schmitt MM, Wahl JA. Size doesn\u2019t matter: needle gauge and injection pain. Gen Dent 2007; 55 (3) : 216-7.","journal-title":"Gen. Dent."},{"key":"ref19","first-page":"96","volume":"23","author":"de St Georges J.","year":"2004","unstructured":"de St Georges J. How dentists are judged by patients. Dent Today 2004; 23 (8) : 96-99, 98-99.","journal-title":"Dent. Today"},{"key":"ref20","unstructured":"Proceedings of the 1st Annual Computer-Controlled Local Anesthesia Delivery (C-CLAD) System meeting. Introductory remarks. New Orleans La 2008."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"647","DOI":"10.14219\/jada.archive.1997.0265","volume":"128","author":"McArdle B.F.","year":"1997","unstructured":"McArdle BF. Painless palatal anesthesia. J Am Dent Assoc 1997; 128 (5) : 647.","journal-title":"J. Am. Dent. 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