{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:18:09Z","timestamp":1773800289507,"version":"3.50.1"},"reference-count":22,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["opendentistryjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TODENTJ"],"published-print":{"date-parts":[[2017,11,24]]},"abstract":"<jats:sec><jats:title>Aim:<\/jats:title><jats:p>The purpose of this study was to compare IL-1\u03b2 and IL-12 gene expression in the gingival tissue of smokers and non-smokers either with healthy periodontium or with chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>41 individuals consisting of 21 healthy controls (11 non-smokers and 10 smokers) and 20 chronic periodontitis patients (10 non-smokers and 10 smokers) participated in this study. Samples were collected from papillary regions of targeted areas and cytokines were analyzed using Real Time PCR. Shapiro-Wilk, Mann-Witney and Independent T tests were employed for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>IL-1\u03b2 gene expression in gingival tissue of non-smoker group with chronic periodontitis was significantly higher than non-smoker-healthy group (<jats:italic>p<\/jats:italic>=0.011). Smoker-chronic periodontitis group showed lower IL-1\u03b2 gene expression than non-smoker-chronic periodontitis group (<jats:italic>p<\/jats:italic>=0.003). IL-12 gene expression was not significantly different between analyzed groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>IL-1\u03b2 gene expression increases in gingival tissue of non-smoker-chronic periodontitis patients due to inflammatory processes but smoking reduces the expression of this cytokine in diseased periodontal tissues. On the other hand periodontal condition and smoking habits do not seem to affect IL-12 gene expressions in gingival tissues. Authors concluded that reduced levels of IL1 and in some extent IL12 in smoking patients are responsible for higher tissue and bone degenerations and less treatment responses in smokers.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874210601711010595","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T06:31:21Z","timestamp":1511505081000},"page":"595-602","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Effects of Smoking on Expression of IL-12 and IL-1\u03b2 in Gingival Tissues of Patients with Chronic Periodontitis"],"prefix":"10.2174","volume":"11","author":[{"given":"Amir","family":"Moeintaghavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Arab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Abdol","family":"Rahim Rezaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani","family":"Naderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Shiezadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saber","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najme","family":"Anvari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Martinez-Canut P, Lorca A, Mag\u00e1n R. Smoking and periodontal disease severity. J Clin Periodontol 1995; 22 (10) : 743-9.","DOI":"10.1111\/j.1600-051X.1995.tb00256.x"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Bergstr\u00f6m J. Cigarette smoking as risk factor in chronic periodontal disease. Community Dent Oral Epidemiol 1989; 17 (5) : 245-7.","DOI":"10.1111\/j.1600-0528.1989.tb00626.x"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Calsina G, Ram\u00f3n JM, Echeverr\u00eda JJ. Effects of smoking on periodontal tissues. J Clin Periodontol 2002; 29 (8) : 771-6. [eng.].","DOI":"10.1034\/j.1600-051X.2002.290815.x"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Garcia RI. Smokers have less reductions in probing depth than non-smokers following nonsurgical periodontal therapy. Evid Based Dent 2005; 6 (2) : 37-8.","DOI":"10.1038\/sj.ebd.6400326"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Ryder MI, Saghizadeh M, Ding Y, Nguyen N, Soskolne A. 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