{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:33:24Z","timestamp":1773329604022,"version":"3.50.1"},"reference-count":14,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["opendentistryjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TODENTJ"],"published-print":{"date-parts":[[2018,1,31]]},"abstract":"\n Introduction:<\/jats:title>\n Von Willebrand Disease is the most common inherited bleeding disorder. In the general population, 1\/8000 patients are affected. Primary hemostasis (platelet adhesion) and coagulation (protection of Factor VIII) are altered. Among several bleeding symptoms, these patients suffer from excessive bleeding of oral mucosa and dental management requires a close collaboration between haematologists and oral surgeons.<\/jats:p>\n <\/jats:sec>\n \n Materials & Methods:<\/jats:title>\n Guided implant surgery can be used to increase the accuracy of implant placement and to reduce the overall morbidity of this surgical procedure by using a flapless surgery technique.<\/jats:p>\n <\/jats:sec>\n \n Case Report:<\/jats:title>\n We report the case of a 49 years old woman having a Type 2A von Willebrand disease and who presented to replace tooth #.46 because of interradicular fracture and peri-apical infection. After planning the implant surgery using Codiagnostix\u00ae<\/jats:sup> software, a surgical guide was prepared. The patient received 4 injections of von Willebrand factor (Willfactin\u00ae<\/jats:sup>) for this particular surgical procedure. The implant was placed immediately after tooth removal and local haemostasis was performed.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n The follow-up was uneventful and the implant was restored by a crown 4 months later. Two cases of implant placement in haemophiliac patients have been reported before in the literature.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n As far as we know, this is the first case report of implant placement in a patient having a von Willebrand disease. The use of guided surgery allowed to perform a mini-invasive procedure and thus contributed to prevent bleeding complications in this patient.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1874210601812010080","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T23:31:31Z","timestamp":1518046291000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report"],"prefix":"10.2174","volume":"12","author":[{"given":"Mathilde","family":"F\u00e9nelon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Castet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Fricain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Catros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1056\/NEJMra1601561","volume":"375","author":"Leebeek F.W.","year":"2016","unstructured":"Leebeek FW, Eikenboom JC. \n Von Willebrand\u2019s disease. \n N Engl J Med \n 2016; \n 375\n (21)\n : 2067-80.","journal-title":"N. Engl. J. Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.ajoms.2016.06.005","volume":"28","author":"Aparna M.","year":"2016","unstructured":"Aparna M. \n A medical elaboration on von Willebrand disease with its dental management. \n J Oral Maxillofac Surg Med Pathol \n 2016; \n 28\n : 442-5.","journal-title":"J Oral Maxillofac Surg Med Pathol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.paed.2015.05.005","volume":"25","author":"Williams M.","year":"2015","unstructured":"Williams M, Patel J. \n Von Willebrand disease: Diagnosis and management. \n Paediatr Child Health \n 2015; \n 25\n : 354-9.","journal-title":"Paediatr. 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Surg."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1601-0825.2005.01111.x","volume":"11","author":"Morimoto Y.","year":"2005","unstructured":"Morimoto Y, Yoshioka A, Sugimoto M, Imai Y, Kirita T. \n Haemostatic management of intraoral bleeding in patients with von Willebrand disease. \n Oral Dis \n 2005; \n 11\n (4)\n : 243-8.","journal-title":"Oral Dis."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jdent.2012.12.008","volume":"41","author":"Diz P.","year":"2013","unstructured":"Diz P, Scully C, Sanz M. \n Dental implants in the medically compromised patient. \n J Dent \n 2013; \n 41\n (3)\n : 195-206.","journal-title":"J. Dent."},{"key":"ref8","first-page":"CD011385","author":"van Galen K.P.","year":"2015","unstructured":"van Galen KP, Engelen ET, Mauser-Bunschoten EP, van Es RJ, Schutgens RE. \n Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. \n Cochrane Database Syst Rev \n 2015; \n (12): \n CD011385.","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e231","DOI":"10.4317\/medoral.20203","volume":"20","author":"Balaguer-Mart\u00ed J-C.","year":"2015","unstructured":"Balaguer-Mart\u00ed J-C, Pe\u00f1arrocha-Oltra D, Balaguer-Mart\u00ednez J, Pe\u00f1arrocha-Diago M. \n Immediate bleeding complications in dental implants: A systematic review. \n Med Oral Patol Oral Cir Bucal \n 2015; \n 20\n (2)\n : e231-8.","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.joms.2005.01.009","volume":"63","author":"Gornitsky M.","year":"2005","unstructured":"Gornitsky M, Hammouda W, Rosen H. \n Rehabilitation of a hemophiliac with implants: A medical perspective and case report. \n J Oral Maxillofac Surg \n 2005; \n 63\n (5)\n : 592-7.","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"911","DOI":"10.11607\/jomi.2627","volume":"28","author":"Smith R.B.","year":"2013","unstructured":"Smith RB, Tarnow DP. \n Classification of molar extraction sites for immediate dental implant placement: Technical note. \n Int J Oral Maxillofac Implants \n 2013; \n 28\n (3)\n : 911-6.","journal-title":"Int. J. Oral Maxillofac. 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