{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:21:00Z","timestamp":1793985660194,"version":"4.8.0"},"reference-count":57,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T00:00:00Z","timestamp":1268784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openmicrobiologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMICROJ"],"published-print":{"date-parts":[[2010,3,17]]},"abstract":"<jats:p>\n                    An extensive portion of the healthcare budget is allocated to chronic human infection. Chronic wounds in particular are a major contributor to this financial burden. Little is known about the types of bacteria which may contribute to the chronicity, biofilm and overall bioburden of the wound itself. In this study we compare the bacteriology of wounds and associated intact skin. Wound and paired intact skin swabs (from a contralateral location) were collected. The bacterial diversity was determined using bacterial Tag-encoded FLX amplicon pyrosequencing (bTEFAP). Diversity analysis showed intact skin to be significantly more diverse than wounds on both the species and genus levels (3% and 5% divergence). Furthermore, wounds show heightened levels of anaerobic bacteria, like\n                    <jats:italic>Peptoniphilus<\/jats:italic>\n                    ,\n                    <jats:italic>Finegoldia<\/jats:italic>\n                    , and\n                    <jats:italic>Anaerococcus<\/jats:italic>\n                    , and other detrimental genera such as\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    . Although some of these and other bacterial genera were found to be common between intact skin and wounds, notable opportunistic wound pathogens were found at lower levels in intact skin. Principal Component Analysis demonstrated a clear separability of the two groups. The findings of the study not only greatly support the hypothesis of differing bacterial composition of intact skin and wounds, but also contribute additional insight into the ecology of skin and wound microflora. The increased diversity and lowered levels of opportunistic pathogens found in skin make the system highly distinguishable from wounds.\n                  <\/jats:p>","DOI":"10.2174\/1874285801004010008","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T13:14:13Z","timestamp":1270646053000},"page":"8-19","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["A Comparison of Bacterial Composition in Diabetic Ulcers and Contralateral Intact Skin"],"prefix":"10.2174","volume":"4","author":[{"given":"Viktoria","family":"Gontcharova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunseog","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall D","family":"Wolcott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot E","family":"Dowd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2007.00283.x","volume":"16","author":"Bjarnsholt T","year":"2008","unstructured":"Bjarnsholt T, Kirketerp-Moller K, Jensen PO, et al. \n            Why chronic wounds will not heal: a novel hypothesis \n            Wound Repair Regen  \n            2008; 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\n            30\n            : 1473-9.","journal-title":"Diabetes Care"},{"key":"refR12","unstructured":"MMWR. History of foot ulcer among persons with diabetes-- United States, 2000-2002 \n            MMWR Morb Mortal Wkly Rep  \n            2003; \n            52\n            : 1098-2."},{"key":"refR13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.12968\/jowc.2009.18.8.43630","volume":"18","author":"Wolcott RD","year":"2009","unstructured":"Wolcott RD, Gontcharova V, Sun Y, Zischkau AM, Dowd SE. \n            Bacterial diversity in surgical site infections: not just aerobic cocci any more \n            J Wound Care  \n            2009; \n            18\n            : 317-23.","journal-title":"J Wound Care"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"e3326","DOI":"10.1371\/journal.pone.0003326","volume":"3","author":"Dowd SE","year":"2008","unstructured":"Dowd SE, Wolcott RD, Sun Y, McKeehan T, Smith E, Rhoads D. \n            Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP) \n            PLoS ONE  \n            2008; \n            3\n            : e3326.","journal-title":"PLoS ONE"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.tifs.2004.02.009","volume":"15","author":"Rowan NJ","year":"2004","unstructured":"Rowan NJ. \n            Viable but non-culturable forms of food and waterborne bacteria: Quo Vadis? \n            Trends Food Sci Technol  \n            2004; \n            15\n            : 462.","journal-title":"Trends Food Sci Technol"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.12968\/jowc.2008.17.12.31769","volume":"17","author":"Wolcott RD","year":"2008","unstructured":"Wolcott RD, Dowd SE. \n            A rapid molecular method for characterising bacterial bioburden in chronic wounds \n            J Wound Care  \n            2008; \n            17\n            : 513-6.","journal-title":"J Wound Care"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"Altschul SF","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. \n            Basic local alignment search tool \n            J Mol Biol  \n            1990; \n            215\n            : 403-10.","journal-title":"J Mol Biol"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1010920819831","volume":"45","author":"Hand DJ","year":"2001","unstructured":"Hand DJ, Till RJ. \n            A Simple Generalisation of the Area Under the ROC Curve for Multiple Class Classification Problems \n            Mach Learn  \n            2001; \n            45\n            : 171-86.","journal-title":"Mach Learn"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.patrec.2005.10.010","volume":"27","author":"Fawcett T","year":"2006","unstructured":"Fawcett T. \n            An introduction to ROC analysis \n            Pattern Recogn Lett  \n            2006; \n            27\n            : 861-74.","journal-title":"Pattern Recogn Lett"},{"key":"refR20","unstructured":"Theodoridis S, Koutroumbas K. \n            Pattern Recognition.  2nd. \n            San Diego, Ca: Academic Press 2008."},{"key":"refR21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1214\/ss\/1177012580","volume":"4","author":"Stigler SM","year":"1989","unstructured":"Stigler SM. \n            Francis Galton's Account of the Invention of Correlation \n            Stat Sci  \n            1989; \n            4\n            : 73-86.","journal-title":"Stat Sci"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2307\/2685263","volume":"42","author":"Rodgers JL","year":"1988","unstructured":"Rodgers JL, Nicewander WA. \n            Thirteen ways to look at the correlation coefficient \n            Am Stat  \n            1988; \n            42\n            : 59-66.","journal-title":"Am Stat"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2105-7-371","volume":"7","author":"Lozupone C","year":"2006","unstructured":"Lozupone C, Hamady M, Knight R. \n            UniFrac--an online tool for comparing microbial community diversity in a phylogenetic context \n            BMC Bioinformatics  \n            2006; \n            7\n            : 371.","journal-title":"BMC Bioinformatics"},{"key":"refR24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.12968\/jowc.2008.17.8.30796","volume":"17","author":"Wolcott RD","year":"2008","unstructured":"Wolcott RD, Rhoads DD, Dowd SE. \n            Biofilms and chronic wound inflammation \n            J Wound Care  \n            2008; 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\n            8\n            : 125.","journal-title":"BMC Microbiol"},{"key":"refR31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.0006-341X.2002.00531.x","volume":"58","author":"Chao A","year":"2002","unstructured":"Chao A, Bunge J. \n            Estimating the number of species in a stochastic abundance model \n            Biometrics  \n            2002; \n            58\n            : 531-9.","journal-title":"Biometrics"},{"key":"refR32","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1128\/jb.109.3.953-965.1972","volume":"109","author":"Brenner DJ","year":"1972","unstructured":"Brenner DJ, Fanning GR, Skerman FJ, Falkow S. \n            Polynucleotide sequence divergence among strains of Escherichia coli and closely related organisms \n            J Bacteriol  \n            1972; \n            109\n            : 953-65.","journal-title":"J Bacteriol"},{"key":"refR33","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/oxfordjournals.jbchem.a021672","volume":"121","author":"Ohnishi Y","year":"1997","unstructured":"Ohnishi Y, Beppu T, Horinouchi S. \n            Two genes encoding serine protease homologues in Serratia marcescens and characterization of their products in Escherichia coli \n            J Biochem  \n            1997; \n            121\n            : 902-13.","journal-title":"J Biochem"},{"key":"refR34","first-page":"705","volume":"18","author":"Langrock ML","year":"2008","unstructured":"Langrock ML, Linde HJ, Landthaler M, Karrer S. \n            Leg ulcers and abscesses caused by Serratia marcescens \n            Eur J Dermatol  \n            2008; \n            18\n            : 705-.","journal-title":"Eur J Dermatol"},{"key":"refR35","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1099\/jmm.0.46075-0","volume":"54","author":"Dekio I","year":"2005","unstructured":"Dekio I, Hayashi H, Sakamoto M, et al. \n            Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling \n            J Med Microbiol  \n            2005; \n            54\n            : 1231-8.","journal-title":"J Med Microbiol"},{"key":"refR36","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1128\/JCM.00799-08","volume":"46","author":"Bek-Thomsen M","year":"2008","unstructured":"Bek-Thomsen M, Lomholt HB, Kilian M. \n            Acne is not associated with yet-uncultured bacteria \n            J Clin Microbiol  \n            2008; \n            46\n            : 3355-60.","journal-title":"J Clin Microbiol"},{"key":"refR37","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1073\/pnas.0607077104","volume":"104","author":"Gao Z","year":"2007","unstructured":"Gao Z, Tseng CH, Pei Z, Blaser MJ. \n            Molecular analysis of human forearm superficial skin bacterial biota \n            Proc Natl Acad Sci USA  \n            2007; \n            104\n            : 2927-32.","journal-title":"Proc Natl Acad Sci USA"},{"key":"refR38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.mi.42.100188.002301","volume":"42","author":"Roth RR","year":"1988","unstructured":"Roth RR, James WD. \n            Microbial ecology of the skin \n            Annu Rev Microbiol  \n            1988; \n            42\n            : 441-64.","journal-title":"Annu Rev Microbiol"},{"key":"refR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2009.01.002","volume":"54","author":"Krutmann J","year":"2009","unstructured":"Krutmann J. \n            Pre- and probiotics for human skin \n            J Dermatol Sci  \n            2009; \n            54\n            : 1-5.","journal-title":"J Dermatol Sci"},{"key":"refR40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S0094837300002633","volume":"1","author":"Raup DM","year":"1975","unstructured":"Raup DM. \n            Taxonomic diversity estimation using rarefaction \n            Paleobiology  \n            1975; \n            1\n            : 333-42.","journal-title":"Paleobiology"},{"key":"refR41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/CMR.10.1.125","volume":"10","author":"Funke G","year":"1997","unstructured":"Funke G, Von GA, Clarridge JE, III Bernard KA. \n            Clinical microbiology of coryneform bacteria \n            Clin Microbiol Rev  \n            1997; \n            10\n            : 125-59.","journal-title":"Clin Microbiol Rev"},{"key":"refR42","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1128\/JB.187.13.4671-4682.2005","volume":"187","author":"Tauch A","year":"2005","unstructured":"Tauch A, Kaiser O, Hain T, et al. \n            Complete genome sequence and analysis of the multiresistant nosocomial pathogen Coryne-bacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora \n            J Bacteriol  \n            2005; \n            187\n            : 4671-82.","journal-title":"J Bacteriol"},{"key":"refR43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1365-4362.1999.00738.x","volume":"38","author":"Bowler PG","year":"1999","unstructured":"Bowler PG, Davies BJ. \n            The microbiology of infected and noninfected leg ulcers \n            Int J Dermatol  \n            1999; \n            38\n            : 573-8.","journal-title":"Int J Dermatol"},{"key":"refR44","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1046\/j.1365-4362.1998.00445.x","volume":"37","author":"Brook I","year":"1998","unstructured":"Brook I, Frazier EH. \n            Aerobic and anaerobic microbiology of chronic venous ulcers \n            Int J Dermatol  \n            1998; \n            37\n            (6)\n            : 426-8.","journal-title":"Int J Dermatol"},{"key":"refR45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/10408418709104438","volume":"14","author":"Brook I","year":"1987","unstructured":"Brook I. \n            Role of encapsulated anaerobic bacteria in synergistic infections \n            Crit Rev Microbiol  \n            1987; \n            14\n            : 171-93.","journal-title":"Crit Rev Microbiol"},{"key":"refR46","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/iai.27.1.44-50.1980","volume":"27","author":"Mayrand D","year":"1980","unstructured":"Mayrand D, McBride BC. \n            Exological relationships of bacteria involved in a simple, mixed anaerobic infection \n            Infect Immun  \n            1980; \n            27\n            : 44-50.","journal-title":"Infect Immun"},{"key":"refR47","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1046\/j.1464-5491.2000.00374-2.x","volume":"17","author":"Urbancic-Rovan V","year":"2000","unstructured":"Urbancic-Rovan V, Gubina M. \n            Bacteria in superficial diabetic foot ulcers \n            Diabet Med  \n            2000; \n            17\n            : 814-5.","journal-title":"Diabet Med"},{"key":"refR48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.12968\/jowc.1996.5.6.277","volume":"5","author":"Trengove NJ","year":"1996","unstructured":"Trengove NJ, Stacey MC, McGechie DF, Mata S. \n            Qualitative bacteriology and leg ulcer healing \n            J Wound Care  \n            1996; 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