{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:17:39Z","timestamp":1761545859022,"version":"build-2065373602"},"reference-count":53,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T00:00:00Z","timestamp":1325203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openmicrobiologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMICROJ"],"published-print":{"date-parts":[[2011,12,30]]},"abstract":"<jats:p>Acute viral bronchiolitis represents the most common lower respiratory tract infection in infants and young children and is associated with substantial morbidity and mortality. Respiratory syncytial virus is the most frequently identified virus, but many other viruses may also cause acute bronchiolitis. There is no common definition of acute viral bronchiolitis used internationally, and this may explain part of the confusion in the literature. Most children with bronchiolitis have a self limiting mild disease and can be safely managed at home with careful attention to feeding and respiratory status. Criteria for referral and admission vary between hospitals as do clinical practice in the management of acute viral bronchiolitis, and there is confusion and lack of evidence over the best treatment for this condition. Supportive care, including administration of oxygen and fluids, is the cornerstone of current treatment. The majority of infants and children with bronchiolitis do not require specific measures. Bronchodilators should not be routinely used in the management of acute viral bronchiolitis, but may be effective in some patients. Most of the commonly used management modalities have not been shown to have a clear beneficial effect on the course of the disease. For example, inhaled and systemic corticosteroids, leukotriene receptor antagonists, immunoglobulins and monoclonal antibodies, antibiotics, antiviral therapy, and chest physiotherapy should not be used routinely in the management of bronchiolitis. The potential effect of hypertonic saline on the course of the acute disease is promising, but further studies are required. In critically ill children with bronchiolitis, today there is little justification for the use of surfactant and heliox. Nasal continuous positive airway pressure may be beneficial in children with severe bronchiolitis but a large trial is needed to determine its value. Finally, very little is known on the effect of the various interventions on the development of post-bronchiolitic wheeze.<\/jats:p>","DOI":"10.2174\/1874285801105010159","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T02:47:01Z","timestamp":1326682021000},"page":"159-164","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of Acute Viral Bronchiolitis"],"prefix":"10.2174","volume":"5","author":[{"given":"Ernst","family":"Eber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1542\/peds.2006-2223","volume":"118","year":"2006","unstructured":"American Academy of Pediatrics. \n                Diagnosis and management of bronchiolitis \n                Pediatrics  \n                2006; \n                118\n                : 1774-93.","journal-title":"Pediatrics"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.5694\/j.1326-5377.2004.tb05993.x","volume":"180","author":"Fitzgerald DA","year":"2004","unstructured":"Fitzgerald DA, Kilham HA. \n                Bronchiolitis: assessment and evidence-based management \n                Med J Aust  \n                2004; \n                180\n                : 399-404.","journal-title":"Med J Aust"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1183\/09031936.00166508","volume":"34","author":"Lenney W","year":"2009","unstructured":"Lenney W, Boner AL, Bont L, et al. \n                Medicines used in respiratory diseases only seen in children \n                Eur Respir J  \n                2009; \n                34\n                : 531-1.","journal-title":"Eur Respir J"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","volume":"282","author":"Shay DK","year":"1999","unstructured":"Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. \n                Bronchiolitis-associated hospitalizations among US children, 1980-1996 \n                JAMA  \n                1999; \n                282\n                : 1440-6.","journal-title":"JAMA"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(06)69077-6","volume":"368","author":"Smyth RL","year":"2006","unstructured":"Smyth RL, Openshaw PJ. \n                Bronchiolitis \n                Lancet  \n                2006; \n                368\n                : 312-22.","journal-title":"Lancet"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","volume":"360","author":"Hall CB","year":"2009","unstructured":"Hall CB, Weinberg GA, Iwane MK, et al. \n                The burden of respiratory syncytial virus infection in young children \n                N Engl J Med  \n                2009; \n                360\n                : 588-98.","journal-title":"N Engl J Med"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1542\/peds.2009-2092","volume":"125","author":"Zorc JJ","year":"2010","unstructured":"Zorc JJ, Hall CB. \n                Bronchiolitis: Recent evidence on diagnosis and management \n                Pediatrics  \n                2010; \n                125\n                : 342-9.","journal-title":"Pediatrics"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.prrv.2009.10.001","volume":"11","author":"Wainwright C","year":"2010","unstructured":"Wainwright C. \n                Acute viral bronchiolitis in children \u2013 a very common condition with few therapeutic options \n                Paediatr Respir Rev  \n                2010; \n                11\n                : 39-45.","journal-title":"Paediatr Respir Rev"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1542\/peds.2007-1135","volume":"121","author":"Unger S","year":"2008","unstructured":"Unger S, Cunningham S. \n                Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis \n                Pediatrics  \n                2008; \n                121\n                : 470-5.","journal-title":"Pediatrics"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/PEC.0b013e318188498c","volume":"24","author":"Babl FE","year":"2008","unstructured":"Babl FE, Sheriff N, Neutze J, Borland M, Oakley E. \n                Bronchiolitis management in pediatric emergency departments in Australia and New Zealand: a PREDICT study \n                Pediatr Emerg Care  \n                2008; \n                24\n                : 656-8.","journal-title":"Pediatr Emerg Care"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1197\/j.aem.2003.12.003","volume":"11","author":"Plint AC","year":"2004","unstructured":"Plint AC, Johnson DW, Wiebe N, et al. \n                Practice variation among pediatric emergency departments in the treatment of bronchiolitis \n                Acad Emerg Med  \n                2004; 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