{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:25:10Z","timestamp":1776417910739,"version":"3.51.2"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openmicrobiologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMICROJ"],"published-print":{"date-parts":[[2012,2,10]]},"abstract":"<jats:p>\n                    During the cholera survey in Namdinh province (northern Vietnam) in July, 2010, one strain of\n                    <jats:italic>Vibrio cholerae<\/jats:italic>\n                    O139 was isolated from 7 environmental water samples positive for\n                    <jats:italic>ctxA, toxR,<\/jats:italic>\n                    <jats:italic>VCO139<\/jats:italic>\n                    genes and named as\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    O139, ND1 strain. This strain was lysogenic harbouring  a genome similar to the filamentous phage fs1. The replicative form DNA of this phage (named as ND1-fs1, 6856 bp) was sequenced and compared with the other filamentous phages. The filamentous phage ND1-fs1 integrates into the region between\n                    <jats:italic>ctxB<\/jats:italic>\n                    and\n                    <jats:italic>rtxA<\/jats:italic>\n                    genes. The genetic organization of the CTX\u03d5 of\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    O139, strain ND1 was determined and the schematic representation of the genetic organization was shown together with the ND1-fs1 prophage.\n                  <\/jats:p>","DOI":"10.2174\/1874285801206010014","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T04:49:23Z","timestamp":1329367763000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of Vibrio cholerae O139 of an Aquatic Isolate in Northern Vietnam"],"prefix":"10.2174","volume":"6","author":[{"given":"Dong Tu","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan Cuong","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy Hoang","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh Huong","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoai Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binh Minh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhu Duong","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0140-6736(93)92841-G","volume":"42","author":"Chongsa-nguan M","year":"1993","unstructured":"Chongsa-nguan M, Chaicumpa W, Moolasart P, et al. \n                Vibrio cholera O139 Bengal in Bangkok. (Letter) \n                Lancet  \n                1993; \n                42\n                : 430-1.","journal-title":"Lancet"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1758-2229.2009.00085.x","volume":"2","author":"Mantri CK","year":"2010","unstructured":"Mantri CK, Mohapatra SS, Colwell RR, Singk DV. \n                Sequence analysis of Vibrio cholerae orfU and zot from pre-CTX\u03d5and CTX\u03d5 reveals multiple origin of pre-CTX\u03d5 and CTX\u03d5 \n                Environmental Microbiol Rep  \n                2010; \n                2\n                : 67-75.","journal-title":"Environmental Microbiol Rep"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1365-2958.1997.3911758.x","volume":"24","author":"Waldor MK","year":"1997","unstructured":"Waldor MK, Rubin EJ, Pearson GD, Kimsey H, Melalanos JJ. \n                Regulation, replication, and integration functions of the Vibrio cholerae CTX\u03d5 are encoded by region RS2 \n                Mol Microbiol  \n                1997; \n                24\n                : 917-26.","journal-title":"Mol Microbiol"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1073\/pnas.140109997","volume":"97","author":"Davis BM","year":"2000","unstructured":"Davis BM, Waldor MK. \n                 CTX\u03d5contains a hybrid genome derived from tandemly integrated elements \n                Proc Natl Acad Sci USA  \n                2000; \n                97\n                : 8572-7.","journal-title":"Proc Natl Acad Sci USA"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1128\/JCM.42.12.5854-5856.2004","volume":"42","author":"Nusrin S","year":"2004","unstructured":"Nusrin S, Khan GY, Bhuiyan NA, et al. \n                Diverse CTX phages among toxigenic Vibrio vholerae O1 and O139 strains isolated between 1994 and 2002 in an area where cholera is endemic in Bangladesh \n                J Clin Microbiol  \n                2004; \n                42\n                : 5854-6.","journal-title":"J Clin Microbiol"},{"key":"refR6","unstructured":"Maniatis T, Fritsch EF, Sambrook J. \n                Molecular cloning: a laboratory manual. \n                New York: Cold Spring Harbor 1982."},{"key":"refR7","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1128\/AEM.67.6.2421-2429.2001","volume":"67","author":"Rivera ING","year":"2001","unstructured":"Rivera ING, Chun J, Huq A,  Sack RB, Colwell RR. \n                Genotypes associated with virulence in environmental isolates of Vibrio cholerae \n                Appl Environ Microbiol  \n                2001; \n                67\n                : 2421-9.","journal-title":"Appl Environ Microbiol"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1128\/jcm.30.8.2118-2121.1992","volume":"30","author":"Fields PI","year":"1992","unstructured":"Fields PI, Popovic T, Wachsmuth K, Olsvik O. \n                Use of Polymerase Chain Reaction for detection of toxigenic Vibrio cholerae O1 strains from the Latin American cholera epidemic \n                J Clin Microbiol  \n                1992; \n                30\n                : 2118-.","journal-title":"J Clin Microbiol"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1574-695X.1998.tb01128.x","volume":"20","author":"Hoshino K","year":"1998","unstructured":"Hoshino K, Yamasaki S, Mukhopadhyay AK, et al. \n                Development and evaluation of a multiplex PCR assay for rapid detection of toxigenic Vibrio cholerae O1 and O139 \n                FEMS Immunol Med Microbiol  \n                1998; \n                20\n                : 201-7.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.resmic.2007.11.015","volume":"159","author":"Ledon T","year":"2008","unstructured":"Ledon T, Campos J, Suzarte E, et al. \n                El Tor and Calcutta CTX\u03d5 precursors coexisting with intact CTX\u03d5 copies in Vibrio cholerae O139 isolates \n                Res Microbiol  \n                2008; \n                159\n                : 81-7.","journal-title":"Res Microbiol"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1128\/JCM.41.6.2306-2310.2003","volume":"41","author":"Qu M","year":"2003","unstructured":"Qu M, Xu J, Ding T, et al. \n                Molecular epidemiology of Vibrio cholerae O139 in China: Polymorphism of Ribotypes and CTX elements \n                J Clin Microbiol  \n                2003; \n                41\n                : 2306-10.","journal-title":"J Clin Microbiol"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.meegid.2010.05.015","volume":"10","author":"Mantri CK","year":"2010","unstructured":"Mantri CK, Mohapatra SS, Signh DV. \n                Effect of storage and sodium chloride on excision of CTX\u03d5 or pre-CTX\u03d5 and CTX\u03d5 from Vibrio cholerae O130 strains \n                Infect Genet Evol  \n                2010; \n                10\n                : 925-30.","journal-title":"Infect Genet Evol"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1099\/mic.0.2006\/000117-0","volume":"152","author":"Maiti D","year":"2006","unstructured":"Maiti D, Das B, Saha A, et al. \n                Genetic organization of pre-CTX and CTX prophages in the genome of an environmental Vibrio cholerae non-O1, non-O139 strain \n                Microbiol  \n                2006; \n                152\n                : 3633-41.","journal-title":"Microbiol"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"98","author":"Southern EM","year":"1975","unstructured":"Southern EM. \n                Detection of specific sequences among DNA fragments separated by gel electrophoresis \n                J Mol Biol  \n                1975; \n                98\n                : 503-17.","journal-title":"J Mol Biol"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0378-1097(97)00345-5","volume":"154","author":"Ehara M","year":"1997","unstructured":"Ehara M, Shimodori S, Kojima F, et al. \n                Characterization of filamentous phages of Vibrio cholerae O139 and O1 \n                FEMS Microbiol Lett  \n                1997; \n                154\n                : 293-301.","journal-title":"FEMS Microbiol Lett"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/AEM.67.2.910-921.2001","volume":"67","author":"Singh DV","year":"2001","unstructured":"Singh DV, Matta MH, Matte GR, et al. \n                Molecular analysis of Vibrio cholerae O1, O139, non-O1, and non-O139 strains: Clonal relationships between clinical and environmental isolates \n                Appl Environ Microbiol  \n                2001; \n                67\n                : 910-21.","journal-title":"Appl Environ Microbiol"},{"key":"refR17","first-page":"5685","volume":"185","author":"Campos J","year":"2003","unstructured":"Campos J, Martinez E, Suzarte E, et al. \n                VGJ\u03d5, an novel filamentous phage of Vibrio cholerae, integrates into the same chromosomal site as CTX\u03d5 \n                2003; \n                185\n                : 5685-96."},{"key":"refR18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1574-6968.1996.tb08550.x","volume":"145","author":"Kar S","year":"1996","unstructured":"Kar S, Ghosh RK, Ghosh AN, Ghosh A. \n                Integration of the DNA of a novel filamentous phage VSK from Vibrio cholerae O139 into the host chromosomal DNA \n                FEMS Microbiol Lett  \n                1996; \n                145\n                : 17-22.","journal-title":"FEMS Microbiol Lett"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1099\/mic.0.032235-0","volume":"156","author":"Campos J","year":"2010","unstructured":"Campos J, Martinez E, Izquierdo Y, Fando R. \n                VEJ\u03d5, a novel filamentous phage of Vibrio cholerae able to transduce the cholera toxin genes \n                Microbiol  \n                2010; \n                156\n                : 108-5.","journal-title":"Microbiol"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1128\/JB.181.9.2902-2913.1999","volume":"181","author":"Nesper J","year":"1999","unstructured":"Nesper J, Bla\u00df J, Foutoulakis M, Reidl J. \n                Characterization of the major control region of Vibrio vcholerae bacteriophage K139: Immunity, exclusion, and integration \n                J Bacteriol  \n                1999; \n                181\n                : 2902-13.","journal-title":"J Bacteriol"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1128\/JCM.42.12.5854-5856.2004","volume":"42","author":"Nusrin S","year":"2004","unstructured":"Nusrin S, Khan GY, Bhuiyan NA, et al. \n                Diverse CTX phage among toxigenic Vibrio cholerae O1 and O139 strains isolated between 1994 and 2002 in an area where cholera is endemic in Bangladesh \n                J Clin Microbiol  \n                2004; \n                42\n                : 5854-6.","journal-title":"J Clin Microbiol"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0140-6736(05)79193-5","volume":"352","author":"Kimsey HH","year":"1998","unstructured":"Kimsey HH, Nair GB, Ghosh A, Waldor MK. \n                Diverse CTX\u03d5 and evolution of new pathogenic Vibrio cholerae \n                Lancet  \n                1998; \n                352\n                : 457-8.","journal-title":"Lancet"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1128\/JB.181.21.6779-6787.1999","volume":"181","author":"Davis BM","year":"1999","unstructured":"Davis BM, Kimsey HH, Chang W, Waldor MK. \n                The Vibrio cholerae O139 Calcutta bacteriophage CTX\u03d5 is infected and encodes a novel repressor \n                J Bacteriol  \n                1999; \n                181\n                : 6779-87.","journal-title":"J Bacteriol"},{"key":"refR24","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1128\/JB.183.16.4737-4746.2001","volume":"183","author":"Mukhopadhyay AK","year":"2001","unstructured":"Mukhopadhyay AK, Chakaraborty S, Takeda Y, Nair GB, Berg DE. \n                Characterization of VPI pathogenicity island and CTX \u03d5 prophage in environmental strains of Vibrio cholerae \n                J Bacteriol  \n                2001; \n                183\n                : 4737-6.","journal-title":"J Bacteriol"},{"key":"refR25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.resmic.2007.11.015","volume":"159","author":"Ledon T","year":"2008","unstructured":"Ledon T, Campos J, Suzarte E, Rodriguez B, Marrero K, Fando R. \n                El Tor and Calcutta CTX\u03d5 precursors coexisting with intact CTX\u03d5 copies in Vibrio cholerae O139 isolates \n                Res Microbiol  \n                2008; \n                159\n                : 81-7.","journal-title":"Res Microbiol"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1574-695X.2009.00590.x","volume":"57","author":"Bhuiyan NA","year":"2009","unstructured":"Bhuiyan NA, Alam M, Motita M, et al. \n                Changing genotypes of cholera toxin (CT) of Vibrio cholerae O139 in Bangladesh and description of three new CT genotypes \n                FEMS Immunol Med Microbiol  \n                2009; \n                57\n                : 136-41.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"refR27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1574-6968.1996.tb08550.x","volume":"145","author":"Kar S","year":"1996","unstructured":"Kar S, Ghosh RK, Ghosh AN, Ghosh A. \n                Integration of the DNA of a novel filamentous bacteriophgae VSK from Vibrio cholerae O139 into the host chromosomal DNA \n                FEMS Miceobiol Lett  \n                1996; \n                145\n                : 17-22.","journal-title":"FEMS Miceobiol Lett"},{"key":"refR28","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1099\/13500872-141-8-1977","volume":"141","author":"Bhadra RK","year":"1995","unstructured":"Bhadra RK, Roychoudhury S, Banerjee RK, et al. \n                Cholera toxin (CTX) genetic element in Vibrio cholerae O139 \n                Microbiol  \n                1995; \n                141\n                : 1977-83.","journal-title":"Microbiol"},{"key":"refR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1574-6968.2008.01200.x","volume":"284","author":"Nguyen DT","year":"2008","unstructured":"Nguyen DT, Nguyen BM, Tran HH, et al. \n                Filamentous vibriophage fs2 encoding the rstC gene integrates into the same chromosomal region as the CTX phage \n                FEMS Microbiol Lett  \n                2008; \n                284\n                : 225-30.","journal-title":"FEMS Microbiol Lett"}],"container-title":["The Open Microbiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V6\/TOMICROJ-6-14\/TOMICROJ-6-14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V6\/TOMICROJ-6-14\/TOMICROJ-6-14.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V6\/TOMICROJ-6-14\/TOMICROJ-6-14.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:53:49Z","timestamp":1761544429000},"score":1,"resource":{"primary":{"URL":"https:\/\/openmicrobiologyjournal.com\/VOLUME\/6\/PAGE\/14\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,10]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2,10]]}},"alternative-id":["TOMICROJ-6-14"],"URL":"https:\/\/doi.org\/10.2174\/1874285801206010014","relation":{},"ISSN":["1874-2858"],"issn-type":[{"value":"1874-2858","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2011-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}