{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:15:59Z","timestamp":1790162159849,"version":"4.1.0"},"reference-count":57,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openmicrobiologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMICROJ"],"published-print":{"date-parts":[[2015,11,3]]},"abstract":"<jats:p>Most microbiome research related to airway diseases has focused on the gut microbiome. This is despite advances in culture independent microbial identification techniques revealing that even healthy lungs possess a unique dynamic microbiome. This conceptual change raises the question; if lung diseases could be causally linked to local dysbiosis of the local lung microbiota. Here, we manipulate the murine lung and gut microbiome, in order to show that the lung microbiota can be changed experimentally. We have used four different approaches: lung inflammation by exposure to carbon nano-tube particles, oral probiotics and oral or intranasal exposure to the antibiotic vancomycin. Bacterial DNA was extracted from broncho-alveolar and nasal lavage fluids, caecum samples and compared by DGGE. Our results show that: the lung microbiota is sex dependent and not just a reflection of the gut microbiota, and that induced inflammation can change lung microbiota. This change is not transferred to offspring. Oral probiotics in adult mice do not change lung microbiome detectible by DGGE. Nasal vancomycin can change the lung microbiome preferentially, while oral exposure does not. These observations should be considered in future studies of the causal relationship between lung microbiota and lung diseases.<\/jats:p>","DOI":"10.2174\/1874285801509010167","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T20:39:06Z","timestamp":1446583146000},"page":"167-179","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The Murine Lung Microbiome Changes During Lung Inflammation and Intranasal Vancomycin Treatment"],"prefix":"10.2174","volume":"9","author":[{"given":"Kenneth Klingenberg","family":"Barfod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katleen","family":"Vrankx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengameh Chlo\u00e9","family":"Mirsepasi-Lauridsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka Stilund","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin S\u00f8rig","family":"Hougaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Thor","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Ouwenhand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Angeliki","family":"Krogfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3109\/00365521.2014.898326","volume":"49","author":"Helander H.F.","year":"2014","unstructured":"Helander HF, F\u00e4ndriks L. Surface area of the digestive tract - revisited Scand J Gastroenterol 2014; 49 (6) : 681-9.","journal-title":"Scand. J. Gastroenterol"},{"key":"refR2","first-page":"391","volume":"112","author":"Hasleton P.S.","year":"1972","unstructured":"Hasleton PS. The internal surface area of the adult human lung J Anat 1972; 112 (Pt 3) : 391-400.","journal-title":"J. Anat"},{"key":"refR3","doi-asserted-by":"publisher","first-page":"e8578","DOI":"10.1371\/journal.pone.0008578","volume":"5","author":"Hilty M.","year":"2010","unstructured":"Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways PLoS One 2010; 5 (1) : e8578.","journal-title":"PLoS One"},{"key":"refR4","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.jaci.2010.10.048","volume":"127","author":"Huang Y.J.","year":"2011","unstructured":"Huang YJ, Nelson CE, Brodie EL, et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma J Allergy Clin Immunol 2011; 127 (2) : 372-381.e1, 3.","journal-title":"J. Allergy Clin. Immunol"},{"key":"refR5","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1164\/rccm.201210-1913OC","volume":"187","author":"Morris A.","year":"2013","unstructured":"Morris A, Beck JM, Schloss PD, et al. Comparison of the respiratory microbiome in healthy nonsmokers and smokers Am J Respir Crit Care Med 2013; 187 (10) : 1067-75.","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"refR6","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s11882-013-0355-y","volume":"13","author":"Huang Y.J.","year":"2013","unstructured":"Huang YJ. Asthma microbiome studies and the potential for new therapeutic strategies Curr Allergy Asthma Rep 2013; 13 (5) : 453-61.","journal-title":"Curr. Allergy Asthma Rep"},{"key":"refR7","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1164\/rccm.201303-0488WS","volume":"187","author":"Huang Y.J.","year":"2013","unstructured":"Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM. The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report Am J Respir Crit Care Med 2013; 187 (12) : 1382-7.","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"refR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1586\/ers.13.24","volume":"7","author":"Dickson R.P.","year":"2013","unstructured":"Dickson RP, Erb-Downward JR, Huffnagle GB. The role of the bacterial microbiome in lung disease Expert Rev Respir Med 2013; 7 (3) : 245-57.","journal-title":"Expert Rev. Respir. Med"},{"key":"refR9","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nri3769","volume":"14","author":"Marsland B.J.","year":"2014","unstructured":"Marsland BJ, Gollwitzer ES. Host-microorganism interactions in lung diseases Nat Rev Immunol 2014; 14 (12) : 827-35.","journal-title":"Nat. Rev. Immunol"},{"key":"refR10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/1471-2180-13-303","volume":"13","author":"Barfod K.K.","year":"2013","unstructured":"Barfod KK, Roggenbuck M, Hansen LH, et al. The murine lung microbiome in relation to the intestinal and vaginal bacterial communities BMC Microbiol 2013; 13 : 303.","journal-title":"BMC Microbiol"},{"key":"refR11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1471-2180-6-98","volume":"6","author":"Licht T.R.","year":"2006","unstructured":"Licht TR, Hansen M, Poulsen M, Dragsted LO. Dietary carbohydrate source influences molecular fingerprints of the rat faecal microbiota BMC Microbiol 2006; 6 : 98.","journal-title":"BMC Microbiol"},{"key":"refR12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2174\/1874285801105010014","volume":"5","author":"Smith B.","year":"2011","unstructured":"Smith B, Li N, Andersen AS, Slotved HC, Krogfelt KA. Optimising bacterial DNA extraction from faecal samples: comparison of three methods Open Microbiol J 2011; 5 : 14-7.","journal-title":"Open Microbiol. J"},{"key":"refR13","doi-asserted-by":"publisher","first-page":"e20113","DOI":"10.1371\/journal.pone.0020113","volume":"6","author":"Wacklin P.","year":"2011","unstructured":"Wacklin P, M\u00e4kivuokko H, Alakulppi N, et al. Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine PLoS One 2011; 6 (5) : e20113.","journal-title":"PLoS One"},{"key":"refR14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3109\/02770900903556413","volume":"47","author":"McLeish A.C.","year":"2010","unstructured":"McLeish AC, Zvolensky MJ. Asthma and cigarette smoking: a review of the empirical literature J Asthma 2010; 47 (4) : 345-61.","journal-title":"J. Asthma"},{"key":"refR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/15287394.2013.863746","volume":"77","author":"Alberg T.","year":"2014","unstructured":"Alberg T, Hansen JS, Lovik M, Nygaard UC. Particles influence allergic responses in mice--role of gender and particle size J Toxicol Environ Health A 2014; 77 (5) : 281-92.","journal-title":"J. Toxicol. Environ. Health A"},{"key":"refR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00204-013-1116-3","volume":"88","author":"Ronzani C.","year":"2014","unstructured":"Ronzani C, Casset A, Pons F. Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma Arch Toxicol 2014; 88 (2) : 489-99.","journal-title":"Arch. Toxicol"},{"key":"refR17","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1378\/chest.10-1861","volume":"139","author":"Forsythe P.","year":"2011","unstructured":"Forsythe P. Probiotics and lung diseases Chest 2011; 139 (4) : 901-8.","journal-title":"Chest"},{"key":"refR18","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.3748\/wjg.15.3261","volume":"15","author":"Ouwehand A.C.","year":"2009","unstructured":"Ouwehand AC, Nermes M, Collado MC, Rautonen N, Salminen S, Isolauri E. Specific probiotics alleviate allergic rhinitis during the birch pollen season World J Gastroenterol 2009; 15 (26) : 3261-8.","journal-title":"World J. Gastroenterol"},{"key":"refR19","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.jaci.2011.02.015","volume":"127","author":"Ly N.P.","year":"2011","unstructured":"Ly NP, Litonjua A, Gold DR, Celed\u00f3n JC. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol 2011; 127 (5) : 1087-94.","journal-title":"J. Allergy Clin. Immunol"},{"key":"refR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.4161\/gmic.1.5.13169","volume":"1","author":"Rauch M.","year":"2010","unstructured":"Rauch M, Lynch SV. Probiotic manipulation of the gastrointestinal microbiota Gut Microbes 2010; 1 (5) : 335-8.","journal-title":"Gut Microbes"},{"key":"refR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.anaerobe.2011.09.006","volume":"18","author":"Grze\u015bkowiak \u0141.","year":"2012","unstructured":"Grze\u015bkowiak \u0141, Gr\u00f6nlund MM, Beckmann C, Salminen S, von Berg A, Isolauri E. The impact of perinatal probiotic intervention on gut microbiota: double-blind placebo-controlled trials in Finland and Germany Anaerobe 2012; 18 (1) : 7-13.","journal-title":"Anaerobe"},{"key":"refR22","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/01.mpg.0000189346.25172.fd","volume":"42","author":"Gueimonde M.","year":"2006","unstructured":"Gueimonde M, Sakata S, Kalliom\u00e4ki M, Isolauri E, Benno Y, Salminen S. Effect of maternal consumption of lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates J Pediatr Gastroenterol Nutr 2006; 42 (2) : 166-70.","journal-title":"J. Pediatr. Gastroenterol. Nutr"},{"key":"refR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/00005176-200403000-00012","volume":"38","author":"Schultz M.","year":"2004","unstructured":"Schultz M, G\u00f6ttl C, Young RJ, Iwen P, Vanderhoof JA. Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization J Pediatr Gastroenterol Nutr 2004; 38 (3) : 293-7.","journal-title":"J. Pediatr. Gastroenterol. Nutr"},{"key":"refR24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4049\/jimmunol.168.1.171","volume":"168","author":"Christensen H.R.","year":"2002","unstructured":"Christensen HR, Fr\u00f8kiaer H, Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells J Immunol 2002; 168 (1) : 171-8.","journal-title":"J. Immunol"},{"key":"refR25","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/j.1365-2222.2006.02629.x","volume":"37","author":"Feleszko W.","year":"2007","unstructured":"Feleszko W, Jaworska J, Rha RD, et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma Clin Exp Allergy 2007; 37 (4) : 498-505.","journal-title":"Clin. Exp. Allergy"},{"key":"refR26","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1164\/rccm.200606-821OC","volume":"175","author":"Forsythe P.","year":"2007","unstructured":"Forsythe P, Inman MD, Bienenstock J. Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice Am J Respir Crit Care Med 2007; 175 (6) : 561-9.","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"refR27","doi-asserted-by":"publisher","unstructured":"Azad MB, Kozyrskyj AL. Perinatal programming of asthma: the role of gut microbiota 2012.","DOI":"10.1155\/2012\/932072"},{"key":"refR28","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1111\/j.1365-2222.2005.02379.x","volume":"35","author":"Noverr M.C.","year":"2005","unstructured":"Noverr MC, Huffnagle GB. The \u2018microflora hypothesis\u2019 of allergic diseases Clin Exp Allergy 2005; 35 (12) : 1511-20.","journal-title":"Clin. Exp. Allergy"},{"key":"refR29","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.jmii.2013.04.005","volume":"46","author":"Kuo C.H.","year":"2013","unstructured":"Kuo CH, Kuo HF, Huang CH, Yang SN, Lee MS, Hung CH. Early life exposure to antibiotics and the risk of childhood allergic diseases: an update from the perspective of the hygiene hypothesis J Microbiol Immunol Infect 2013; 46 (5) : 320-9.","journal-title":"J. Microbiol. Immunol. Infect"},{"key":"refR30","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/embor.2012.32","volume":"13","author":"Russell S.L.","year":"2012","unstructured":"Russell SL, Gold MJ, Hartmann M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma EMBO Rep 2012; 13 (5) : 440-7.","journal-title":"EMBO Rep"},{"key":"refR31","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1007\/s00125-012-2564-7","volume":"55","author":"Hansen C.H.","year":"2012","unstructured":"Hansen CH, Krych L, Nielsen DS, et al. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse Diabetologia 2012; 55 (8) : 2285-94.","journal-title":"Diabetologia"},{"key":"refR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1128\/IAI.73.1.30-38.2005","volume":"73","author":"Noverr M.C.","year":"2005","unstructured":"Noverr MC, Falkowski NR, McDonald RA, McKenzie AN, Huffnagle GB. Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13 Infect Immun 2005; 73 (1) : 30-8.","journal-title":"Infect. Immun"},{"key":"refR33","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1128\/IAI.01520-08","volume":"77","author":"Antonopoulos D.A.","year":"2009","unstructured":"Antonopoulos DA, Huse SM, Morrison HG, Schmidt TM, Sogin ML, Young VB. Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation Infect Immun 2009; 77 (6) : 2367-75.","journal-title":"Infect. Immun"},{"key":"refR34","doi-asserted-by":"publisher","first-page":"158","DOI":"10.4161\/gmic.23567","volume":"4","author":"Russell S.L.","year":"2013","unstructured":"Russell SL, Gold MJ, Willing BP, Thorson L, McNagny KM, Finlay BB. Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma Gut Microbes 2013; 4 (2) : 158-64.","journal-title":"Gut Microbes"},{"key":"refR35","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1136\/jcp.48.7.689-b","volume":"48","author":"Armstrong C.J.","year":"1995","unstructured":"Armstrong CJ, Wilson TS. Systemic absorption of vancomycin J Clin Pathol 1995; 48 (7) : 689.","journal-title":"J. Clin. Pathol"},{"key":"refR36","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"Kilkenny C.","year":"2010","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research PLoS Biol 2010; 8 (6) : e1000412.","journal-title":"PLoS Biol"},{"key":"refR37","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.reprotox.2013.05.006","volume":"41","author":"Hougaard K.S.","year":"2013","unstructured":"Hougaard KS, Jackson P, Kyjovska ZO, et al. Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice Reprod Toxicol 2013; 41 : 86-97.","journal-title":"Reprod. Toxicol"},{"key":"refR38","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1080\/15287394.2013.838915","volume":"76","author":"Hansen J.S.","year":"2013","unstructured":"Hansen JS, Nielsen GD, S\u00f8rli JB, Clausen PA, Wolkoff P, Larsen ST. Adjuvant and inflammatory effects in mice after subchronic inhalation of allergen and ozone-initiated limonene reaction products J Toxicol Environ Health A 2013; 76 (19) : 1085-95.","journal-title":"J. Toxicol. Environ. Health A"},{"key":"refR39","doi-asserted-by":"publisher","first-page":"e11065","DOI":"10.1371\/journal.pone.0011065","volume":"5","author":"Weiss G.","year":"2010","unstructured":"Weiss G, Rasmussen S, Nielsen Fink L, Jarmer H, N\u00f8hr Nielsen B, Fr\u00f8kiaer H. Bifidobacterium bifidum actively changes the gene expression profile induced by Lactobacillus acidophilus in murine dendritic cells PLoS One 2010; 5 (6) : e11065.","journal-title":"PLoS One"},{"key":"refR40","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1097\/MPG.0b013e318263066c","volume":"55","author":"G\u00f8bel R.J.","year":"2012","unstructured":"G\u00f8bel RJ, Larsen N, Jakobsen M, M\u00f8lgaard C, Michaelsen KF. Probiotics to adolescents with obesity: effects on inflammation and metabolic syndrome J Pediatr Gastroenterol Nutr 2012; 55 (6) : 673-8.","journal-title":"J. Pediatr. Gastroenterol. Nutr"},{"key":"refR41","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1574-6941.2010.01024.x","volume":"75","author":"Larsen N.","year":"2011","unstructured":"Larsen N, Vogensen FK, G\u00f8bel R, et al. Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 FEMS Microbiol Ecol 2011; 75 (3) : 482-96.","journal-title":"FEMS Microbiol. Ecol"},{"key":"refR42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/AEM.59.3.695-700.1993","volume":"59","author":"Muyzer G.","year":"1993","unstructured":"Muyzer G, de Waal EC, Uitterlinden AG. Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA Appl Environ Microbiol 1993; 59 (3) : 695-700.","journal-title":"Appl. Environ. Microbiol"},{"key":"refR43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2307\/1217208","volume":"11","author":"Robert R.","year":"1962","unstructured":"Robert R. Sokal, F.James Rohlf. The comparison of dendrograms by objective methods Taxon 1962; 11 (2) : 33-40.","journal-title":"Taxon"},{"key":"refR44","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1128\/JCM.26.11.2465-2466.1988","volume":"26","author":"Hunter P.R.","year":"1988","unstructured":"Hunter PR, Gaston MA. Numerical index of the discriminatory ability of typing systems: an application of Simpson\u2019s index of diversity J Clin Microbiol 1988; 26 (11) : 2465-6.","journal-title":"J. Clin. Microbiol"},{"key":"refR45","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0022-5193(66)90013-0","volume":"13","author":"Pielou E.C.","year":"1966","unstructured":"Pielou EC. The measurement of diversity in different types of biological collections J Theor Biol 1966; 13 : 131-44.","journal-title":"J. Theor. Biol"},{"key":"refR46","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12915-014-0087-z","volume":"12","author":"Salter S.J.","year":"2014","unstructured":"Salter SJ, Cox MJ, Turek EM, et al. Reagent and laboratory contamination can critically impact sequence-based microbiome analyses BMC Biol 2014; 12 : 87.","journal-title":"BMC Biol"},{"key":"refR47","doi-asserted-by":"publisher","first-page":"e02284","DOI":"10.1128\/mBio.02284-14","volume":"6","author":"Venkataraman A.","year":"2015","unstructured":"Venkataraman A, Bassis CM, Beck JM, et al. Application of a neutral community model to assess structuring of the human lung microbiome MBio 2015; 6 (1) : e02284-14.","journal-title":"MBio"},{"key":"refR48","doi-asserted-by":"publisher","first-page":"e46231","DOI":"10.1371\/journal.pone.0046231","volume":"7","author":"Bangsgaard Bendtsen K.M.","year":"2012","unstructured":"Bangsgaard Bendtsen KM, Krych L, S\u00f8rensen DB, et al. Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB\/c mouse PLoS One 2012; 7 (10) : e46231.","journal-title":"PLoS One"},{"key":"refR49","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1258\/la.2010.010058","volume":"44","author":"Hufeldt M.R.","year":"2010","unstructured":"Hufeldt MR, Nielsen DS, Vogensen FK, Midtvedt T, Hansen AK. Family relationship of female breeders reduce the systematic inter-individual variation in the gut microbiota of inbred laboratory mice Lab Anim 2010; 44 (4) : 283-9.","journal-title":"Lab. Anim"},{"key":"refR50","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.4049\/jimmunol.1400085","volume":"193","author":"Hansen C.H.","year":"2014","unstructured":"Hansen CH, Andersen LS, Krych L, et al. Mode of delivery shapes gut colonization pattern and modulates regulatory immunity in mice J Immunol 2014; 193 (3) : 1213-22.","journal-title":"J. Immunol"},{"key":"refR51","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.immuni.2013.08.013","volume":"39","author":"Yurkovetskiy L.","year":"2013","unstructured":"Yurkovetskiy L, Burrows M, Khan AA, et al. Gender bias in autoimmunity is influenced by microbiota Immunity 2013; 39 (2) : 400-12.","journal-title":"Immunity"},{"key":"refR52","doi-asserted-by":"publisher","first-page":"4500","DOI":"10.1038\/ncomms5500","volume":"5","author":"Bolnick D.I.","year":"2014","unstructured":"Bolnick DI, Snowberg LK, Hirsch PE, et al. Individual diet has sex-dependent effects on vertebrate gut microbiota Nat Commun 2014; 5 : 4500.","journal-title":"Nat. Commun"},{"key":"refR53","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1164\/rccm.201403-0428LE","volume":"190","author":"Genuneit J.","year":"2014","unstructured":"Genuneit J. Sex-specific development of asthma differs between farm and nonfarm children: a cohort study Am J Respir Crit Care Med 2014; 190 (5) : 588-90.","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"refR54","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/MOG.0b013e3283573017","volume":"28","author":"Russell S.L.","year":"2012","unstructured":"Russell SL, Finlay BB. The impact of gut microbes in allergic diseases Curr Opin Gastroenterol 2012; 28 (6) : 563-9.","journal-title":"Curr. Opin. Gastroenterol"},{"key":"refR55","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1084\/jem.20090845","volume":"206","author":"Conrad M.L.","year":"2009","unstructured":"Conrad ML, Ferstl R, Teich R, et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78 J Exp Med 2009; 206 (13) : 2869-77.","journal-title":"J. Exp. Med"},{"key":"refR56","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.jaci.2011.04.035","volume":"128","author":"Brand S.","year":"2011","unstructured":"Brand S, Teich R, Dicke T, et al. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes J Allergy Clin Immunol 2011; 128 (3) : 618-25.e1, 7.","journal-title":"J. Allergy Clin. Immunol"},{"key":"refR57","doi-asserted-by":"publisher","first-page":"e113466","DOI":"10.1371\/journal.pone.0113466","volume":"9","author":"Yun Y.","year":"2014","unstructured":"Yun Y, Srinivas G, Kuenzel S, et al. Environmentally determined differences in the murine lung microbiota and their relation to alveolar architecture PLoS One 2014; 9 (12) : e113466.","journal-title":"PLoS One"}],"container-title":["The Open Microbiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V9\/TOMICROJ-9-167\/TOMICROJ-9-167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V9\/TOMICROJ-9-167\/TOMICROJ-9-167.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V9\/TOMICROJ-9-167\/TOMICROJ-9-167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T21:33:34Z","timestamp":1599773614000},"score":1,"resource":{"primary":{"URL":"https:\/\/openmicrobiologyjournal.com\/VOLUME\/9\/PAGE\/167\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,11,3]]}},"alternative-id":["TOMICROJ-9-167"],"URL":"https:\/\/doi.org\/10.2174\/1874285801509010167","relation":{},"ISSN":["1874-2858"],"issn-type":[{"value":"1874-2858","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2015-3-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-9-1","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-9-2","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-3","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}