{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:17:49Z","timestamp":1780420669354,"version":"3.54.1"},"reference-count":27,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":["openmicrobiologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMICROJ"],"published-print":{"date-parts":[[2016,6,30]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To identify laboratory and clinical characteristics of different pathogens associated with early-onset sepsis (EOS) of the newborn.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Newborns with EOS were retrospectively analyzed regarding laboratory and clinical parameters associated with the identified pathogen.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 125 newborns having diagnosis of culture proven EOS between 1993 and 2011. One hundred cases had diagnosis of group B streptococci (GBS) infection (80%), 11 had <jats:italic>Escherichia coli<\/jats:italic> (8.8%), eight enterococci (6.4%), and six other pathogens (4.8%). White blood cell count (WBC), immature to total neutrophil (IT) ratio, and C-reactive protein (CRP) values did not differ between groups within the first 72 hours of life. Presence of high (&gt;30000\/\u00b5L) and low (&lt;9000\/\u00b5l) WBC was significantly less found compared with IT-ratio &gt;0.2 in GBS and <jats:italic>E.coli<\/jats:italic> EOS. High WBC were more common found than low WBC in all groups. Gram positive pathogens were more common found in late preterm and term infants (84%), and gram negative pathogens more common in very low birth weight infants (64%). <jats:italic>E. coli<\/jats:italic> was significantly associated with lower gestational age and birth weight, respectively.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An abnormal IT-ratio was a more common finding than an abnormal WBC in GBS and <jats:italic>E. coli<\/jats:italic> EOS. <jats:italic>E. coli<\/jats:italic> was significantly associated with prematurity.<\/jats:p>\n                <\/jats:sec>","DOI":"10.2174\/1874285801610010133","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T22:16:47Z","timestamp":1467325007000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison Between Pathogen Associated Laboratory and Clinical Parameters in Early-Onset Sepsis of the Newborn"],"prefix":"10.2174","volume":"10","author":[{"given":"Bernhard","family":"Resch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renoldner","family":"B","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hofer","family":"N","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","author":"Cortese F.","year":"2015","unstructured":"Cortese F, Scicchitano P, Gesualdo M, et al. \n                    Early and late infections in Newborns: Where do we stand? 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