{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:34:54Z","timestamp":1753889694424,"version":"3.41.2"},"reference-count":26,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openrespiratorymedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORMJ"],"published-print":{"date-parts":[[2022,10,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                <jats:p>This study aimed to determine the prevalence and criteria of wheat allergy (WA) among patients with resistant allergic conjunctivitis (AC).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                <jats:p>A prospective comparative study was conducted on 100 patients with resistant AC. Skin prick-tests (SPTs), total and sIgE against a panel of inhalant and food allergens were performed in all patients\u2019 sera. They were divided into 2 groups according to skin prick test (SPT) and specific IgE (sIgE) level, namely the wheat sensitive group (WSG) and wheat tolerant group (WTG). Total ocular symptom scores (TOSS) and 4-point sign scales were correlated for both groups.<\/jats:p>\n                <\/jats:sec>\n            <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                <jats:p>Ten patients out of 100 with IgE-mediated resistant AC were wheat sensitive, and the other 90 were wheat tolerant patients. WSG included patients of significantly younger age. Positive family history of atopy was proven in <jats:italic>100<\/jats:italic>% of WSG vs. 67% of WTG. A significantly higher frequency of multiorgan allergy was detected in 100% of WSG vs. 20% in WTG (<jats:italic>P<\/jats:italic> = 0.0001). Thirty (30%) of WSG had associated allergic rhinitis (AR) and bronchial asthma (BA). Another 30% had an associated AR only, 10% had an associated BA only, and another 20% had an associated skin allergy. TOSS, 4- point sign scale, and total IgE level were significantly higher in WSG.<\/jats:p>\n                <\/jats:sec>\n            <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                <jats:p>This study provides novel evidence that wheat allergy is responsible for some severe forms of AC.<\/jats:p>\n            <\/jats:sec>","DOI":"10.2174\/18743064-v16-e2208170","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T09:50:21Z","timestamp":1665395421000},"update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IgE Mediated Wheat Allergy Associated with Resistant and Severe Forms of Allergic Conjunctivitis"],"prefix":"10.2174","volume":"16","author":[{"given":"Khulood M.","family":"Sayed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdellah H.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/15569527.2014.890938","volume":"34","author":"Mimura T.","year":"2015","unstructured":"Mimura T, Yamagami S, Noma H, et al. \n                    Specific IgE for wheat in tear fluid of patients with allergic conjunctivitis. \n                    Cutan Ocul Toxicol  \n                    2015; \n                    34\n                    (1)\n                    : 25-34.","journal-title":"Cutan. 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