{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:28:29Z","timestamp":1787063309994,"version":"build-2736575974"},"reference-count":15,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openrespiratorymedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORMJ"],"published-print":{"date-parts":[[2014,1,24]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Drug inhalation via a dry-powder inhaler (DPI) is a convenient, time efficient alternative to\nnebulizers in the treatment of cystic fibrosis (CF) or non-CF bronchiectasis. Efficient drug administration via DPIs\ndepends on the device resistance and adequate (\u226545L\/min) inspiratory flows and volumes generated by individuals. Drypowder\nmannitol is delivered using a RS01 breath-actuated device developed by Plastiape, for Pharmaxis. The study aim\nwas to determine in vivo if non-CF bronchiectasis patients\u2019 inspiratory flows and volumes are adequate to use the RS01\nDPI device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methodology:<\/jats:title>\n                    <jats:p>An open, non-interventional study; enrolled 17 subjects with non-CF bronchiectasis, 18 to 80\nyears, with baseline FEV1 \u22651.0L and \u226550\u2030 predicted. Inspiratory flows and volumes were measured when subjects\ninhaled in a controlled manner through the RS01 device in series with a spirometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean inspiratory volume (IV) of non-CF bronchiectasis subjects was 2.08 \u00b1 0.5L and achieved a mean PIF\nof 78.6 \u00b1 11.2L\/min with the inhaler device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Use of the RS01 DPI device allowed adequate inspiratory flow and volume for dispersion of dry-powder\nmannitol in non-CF bronchiectasis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874306401408010008","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:17:02Z","timestamp":1392855422000},"page":"8-13","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inspiratory Flows and Volumes in Subjects with Non-CF Bronchiectasis Using a New Dry Powder Inhaler Device"],"prefix":"10.2174","volume":"8","author":[{"given":"Mark R.","family":"Elkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra D.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare P.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Daviskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Charlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijpharm.2007.08.013","volume":"349","author":"Glover W","year":"2008","unstructured":"Glover W, Chan H-K, Eberl S, Daviskas E, Verschuer J. \n                    Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers. \n                    Int J Pharm  \n                    2008; 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