{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:05:39Z","timestamp":1789203939672,"version":"build-2803163510"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openrespiratorymedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORMJ"],"published-print":{"date-parts":[[2015,6,26]]},"abstract":"<jats:p>Transfusion-related acute lung injury (TRALI) is a life-threatening intervention that develops within 6 hours of transfusion of one or more units of blood, and is an important cause of morbidity and mortality resulting from transfusion. It is necessary to dismiss other causes of acute lung injury (ALI), like sepsis, acute cardiogenic edema, acute respiratory distress syndrome (ARDS) or bacterial infection. There are two mechanisms that lead to the development of this syndrome: immune-mediated and no immune- mediated TRALI. A common theme among the experimental TRALI models is the central importance of neutrophils in mediating the early immune response, and lung vascular injury. Central clinical symptoms are dyspnea, tachypnea, tachycardia, cyanosis and pulmonary secretions, altogether with other hemodynamic alterations, such as hypotension and fever. Complementary to these clinical findings, long-term validated animal models for TRALI should allow the determination of the cellular targets for TRALI-inducing alloantibodies as well as delineation of the underlying pathogenic molecular mechanisms, and key molecular mediators of the pathology. Diagnostic criteria have been established and preventive measures have been implemented. These actions have contributed to the reduction in the overallnumber of fatalities. However, TRALI still remains a clinical problem. Any complication suspected of TRALI should immediately be reported.<\/jats:p>","DOI":"10.2174\/1874306401509010092","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T07:27:14Z","timestamp":1437031634000},"page":"92-96","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Transfusion-Related Acute Lung Injured (TRALI): Current Concepts"],"prefix":"10.2174","volume":"9","author":[{"given":"P","family":"\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Romero-Dapueto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/j.0041-1132.2004.04347.x","volume":"44","author":"Kleinman S","year":"2004","unstructured":"Kleinman S, Caulfield T, Chan P , et al. Toward an understanding of transfusion-related acute lung injury statement of a consensus panel Transfusion 2004; 44 : 1774-89.","journal-title":"Transfusion"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/01.CCM.0000159849.94750.51","volume":"33","author":"Toy P","year":"2005","unstructured":"Toy P, Popovsky MA, Abraham E , et al. Transfusion-related acute lung injury Definition and review Crit Care Med 2005; 33 : 721-6.","journal-title":"Crit Care Med"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1537-2995.1985.25686071434.x","volume":"25","author":"Popovsky MA","year":"1985","unstructured":"Popovsky MA, Moore SB. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury Transfusion 1985; 25 : 573-7.","journal-title":"Transfusion"},{"key":"refR4","first-page":"320","volume":"67","author":"Vlaar AP","year":"2009","unstructured":"Vlaar AP, Schultz MJ, Juffermans NP. Transfusion-related acute lung injury a change of perspective Neth J Med 2009; 67 : 320-6.","journal-title":"Neth J Med"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1537-2995.2006.00956.x","volume":"46","author":"Kleinman S","year":"2006","unstructured":"Kleinman S. A perspective on transfusion-related acute lung injury two years after the Canadian Consensus Conference Transfusion 2006; 46 : 1465-8.","journal-title":"Transfusion"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.medin.2009.03.007","volume":"34","author":"A\u00f1\u00f3n JM","year":"2010","unstructured":"A\u00f1\u00f3n JM, Garc\u00eda de Lorenzo A, Quintana M , et al. Transfusion-related acute lung injury Med Intensiva 2010; 34 : 139-49.","journal-title":"Med Intensiva"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1097\/CCM.0b013e31818c3801","volume":"36","author":"Marik PE","year":"2008","unstructured":"Marik PE, Corwin HL. Acute lung injury following to transfusion expanding the definition Crit Care Med 2008; 36 : 3080-4.","journal-title":"Crit Care Med"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00408-005-2578-8","volume":"184","author":"Swanson K","year":"2006","unstructured":"Swanson K, Dwyre DM, Krochmal J, Raife TJ. Transfusion-related acute lung injury (TRALI): current clinical and pathophysiologic considerations Lung 2006; 184 : 177-85.","journal-title":"Lung"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1586\/ehm.11.74","volume":"5","author":"M\u00fcller MC","year":"2012","unstructured":"M\u00fcller MC, Juffermans NP. Transfusion-related acute lung injury a preventable syndrome\u03ba Expert Rev Hematol 2012; 5 : 97-106.","journal-title":"Expert Rev Hematol"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1423-0410.2008.01144.x","volume":"96","author":"Bierling P","year":"2009","unstructured":"Bierling P, Bux J, Curtis B , et al. Recommendations of the ISBT working party on granulocyte immunobiology for leucocyte antibody screening in the investigation and prevention of antibody-mediated transfusion-related acute lung injury Vox Sang 2009; 96 : 266-9.","journal-title":"Vox Sang"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1423-0410.2005.00648.x","volume":"89","author":"Bux J","year":"2005","unstructured":"Bux J. Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion Vox Sang 2005; 89 : 1-10.","journal-title":"Vox Sang"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1182\/blood-2004-07-2929","volume":"105","author":"Silliman CC","year":"2005","unstructured":"Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury Blood 2005; 105 : 2266-73.","journal-title":"Blood"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5603\/CJ.2013.0091","volume":"20","author":"Jaworski K","year":"2013","unstructured":"Jaworski K, Ma\u03balanka K, Kosior DA. Transfusion-related acute lung injury a dangerous and under diagnosed noncardiogenic pulmonary edema Cardiol J 2013; 20 : 337-44.","journal-title":"Cardiol J"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1182\/blood-2011-12-395897","volume":"119","author":"Shaz BH","year":"2012","unstructured":"Shaz BH. Giving TRALI the one-two punch Blood 2012; 119 : 1620-.","journal-title":"Blood"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1365-2141.2007.06492.x","volume":"136","author":"Bux J","year":"2007","unstructured":"Bux J, Sachs U. The pathogenesis of transfusion-related acute lung injury (TRALI) Br J Haematol 2007; 136 : 788-99.","journal-title":"Br J Haematol"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1182\/blood.V76.7.1438.1438","volume":"76","author":"Seeger W","year":"1990","unstructured":"Seeger W, Schneider U, Kreusler B , et al. Reproduction of transfusion-related acute lung injury in an ex vivo lung model Blood 1990; 76 : 1438-44.","journal-title":"Blood"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1182\/blood-2005-04-1744","volume":"107","author":"Sachs UJ","year":"2006","unstructured":"Sachs UJ, Hattar K, Weissmann N , et al. Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat model Blood 2006; 107 : 1217-9.","journal-title":"Blood"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1537-2995.2003.00385.x","volume":"43","author":"Silliman CC","year":"2003","unstructured":"Silliman CC, Bjornsen AJ, Wyman TH , et al. Plasma and lipids from stored platelets cause acute lung injury in an animal model Transfusion 2003; 43 : 633-40.","journal-title":"Transfusion"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tmrv.2008.09.002","volume":"23","author":"L\u00f6gdberg LE","year":"2009","unstructured":"L\u00f6gdberg LE, Vikulina T, Zimring JC, Hillyer CD. Animal models of transfusion-related acute lung injury Transfus Med Rev 2009; 23 : 13-24.","journal-title":"Transfus Med Rev"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1365-2141.1996.d01-1703.x","volume":"93","author":"Bux J","year":"1996","unstructured":"Bux J, Becker F, Seeger W , et al. Transfusion-related acute lung injury due to HLA-A2-specific antibodies in recipient and NB1-specific antibodies in donor blood Br J Haematol 1996; 93 : 707-13.","journal-title":"Br J Haematol"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/187152507782109845","volume":"5","author":"Vlaar AP","year":"2007","unstructured":"Vlaar AP, Zweers MM, Schultz MJ , et al. Developing specific therapeutic strategies for transfusion-related acute lung injury an overview of potentially useful animal models Cardiovasc Hematol Agents Med Chem 2007; 5 : 319-26.","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/j.1537-2995.2011.03490.x","volume":"52","author":"Wo\u03baniak MJ1","year":"2012","unstructured":"Wo\u03baniak MJ1, Bowring C, Lucas G, Ridgwell K. Detection of HNA-3a and -3b antibodies using transfected cell lines and recombinant proteins Transfusion 2012; 52 : 1458-67.","journal-title":"Transfusion"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.CCM.0000199069.19193.89","volume":"34","author":"Ritter C","year":"2006","unstructured":"Ritter C, da Cunha AA, Echer IC , et al. Effects of N-acetylcysteine plus deferoxamine in lipopolysaccharide induced acute lung injury in the rat Crit Care Med 2006; 34 : 471-7.","journal-title":"Crit Care Med"},{"key":"refR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.7861\/clinmedicine.9-1-87","volume":"9","author":"Aravinthan A","year":"2009","unstructured":"Aravinthan A, Sen S, Marcus N. Transfusion-related acute lung injury a rare and life-threatening complication of a common procedure Clin Med 2009; 9 : 87-9.","journal-title":"Clin Med"},{"key":"refR25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1182\/asheducation-2006.1.497","author":"Triulzi DJ","year":"2006","unstructured":"Triulzi DJ. Transfusion-related acute lung injury an update Hematol Am Soc Hematol Educ Program 2006; 497-501.","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1537-2995.2006.01148.x","volume":"47","author":"Fadeyi EA","year":"2007","unstructured":"Fadeyi EA, De Los Angeles MM, Wayen AS , et al. The transfusion of neutrophil-specific antibodies causes leukopenia and a broad spectrum of pulmonary reactions Transfusion 2007; 47 : 545-0.","journal-title":"Transfusion"},{"key":"refR27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0210-5691(07)74765-4","volume":"31","author":"Gordo Vidal F","year":"2007","unstructured":"Gordo Vidal F, Delgado Arnaiz C, CalvoHerranz E. Mechanical ventilation induced lung injury Med Intensiva 2007; 31 : 18-26.","journal-title":"Med Intensiva"},{"key":"refR28","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0140-6736(12)62197-7","volume":"382","author":"Vlaar AP","year":"2013","unstructured":"Vlaar AP, Juffermans NP. Transfusion-related acute lung injury a clinical review Lancet 2013; 382 : 984-4.","journal-title":"Lancet"},{"key":"refR29","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1097\/01.CCM.0000214312.20718.3E","volume":"34","author":"Moore SB","year":"2006","unstructured":"Moore SB. Transfusion-related acute lung injury (TRALI): clinical presentation, treatment, and prognosis Crit Care Med 2006; 34 : S114-7.","journal-title":"Crit Care Med"}],"container-title":["The Open Respiratory Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openrespiratorymedicinejournal.com\/contents\/volumes\/V9\/TORMJ-9-92\/TORMJ-9-92.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrespiratorymedicinejournal.com\/contents\/volumes\/V9\/TORMJ-9-92\/TORMJ-9-92.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrespiratorymedicinejournal.com\/contents\/volumes\/V9\/TORMJ-9-92\/TORMJ-9-92.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T02:55:53Z","timestamp":1599274553000},"score":1,"resource":{"primary":{"URL":"https:\/\/openrespiratorymedicinejournal.com\/VOLUME\/9\/PAGE\/92\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,6,26]]}},"alternative-id":["TORMJ-9-92"],"URL":"https:\/\/doi.org\/10.2174\/1874306401509010092","relation":{},"ISSN":["1874-3064"],"issn-type":[{"value":"1874-3064","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2015-3-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-4-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-4-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-6-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}