{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:03:55Z","timestamp":1761419035640},"reference-count":13,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openrespiratorymedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORMJ"],"published-print":{"date-parts":[[2016,7,15]]},"abstract":"\n Background:<\/jats:title>\n Prefabricated adjustable thermoplastic mandibular advancement devices (PAT-MADs) are a practical short-term treatment for obstructive sleep apnoea-hypopnoea syndrome (OSAHS) in patients who have failed or refused continuous positive airway pressure (CPAP) therapy.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To assess the effectiveness of a new professionally-fitted PAT-MAD in patients with OSAHS in Morocco.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n Twenty-four adults with mild, moderate or severe OSAHS were fitted with the PAT-MAD (BluePro\u00ae<\/jats:sup>; BlueSom, France). Respiratory parameters (apnoea-hypopnoea index (AHI), oxygen desaturation index (ODI)) and daytime sleepiness using the Epworth Sleepiness scale (ESS) were assessed before and after treatment. Adverse events were recorded.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Mean treatment duration was 106.3 \u00b1 73.4 days. Mean AHI score decreased from 21.4 \u00b1 7.4 to 9.3 \u00b1 4.1 after treatment (p<\/jats:italic><0.0001) (mean reduction of 57.0 \u00b1 12.3%). Mean ESS and ODI also decreased at EOS (from 10.4 \u00b1 2.8 to 7.3 \u00b1 2.3, mean reduction 30.3 \u00b1 12.2%, p<\/jats:italic>=0.0001; and 7.0 \u00b1 6.9 to 4.7 \u00b1 4.0, mean reduction 30.5 \u00b1 25.0%, p<\/jats:italic>=0.2, respectively). Treatment was considered to have been successful in 22 patients (91.7%) who had mild OSAHS or an AHI score of \u22645 at the end of the study. The device was well-tolerated.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This new PAT-MAD appears to be effective at reducing respiratory parameters and improving daytime alertness in patients with OSAHS. Long term studies in a larger number of patients are warranted to assess the long-term efficacy, retention and side-effects of this device.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1874306401610010046","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T10:13:57Z","timestamp":1468577637000},"page":"46-50","update-policy":"http:\/\/dx.doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pilot Study of a New Adjustable Thermoplastic Mandibular Advancement Device for the Management of Obstructive Sleep Apnoea-Hypopnoea Syndrome: A Brief Research Letter"],"prefix":"10.2174","volume":"10","author":[{"given":"Mohammed","family":"El Ibrahimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounir","family":"Laabouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/2040622315590318","volume":"6","author":"Spicuzza L.","year":"2015","unstructured":"Spicuzza L, Caruso D, Di Maria G. \n Obstructive sleep apnoea syndrome and its management. \n Ther Adv Chronic Dis \n 2015; \n 6\n (5)\n : 273-85.","journal-title":"Ther. 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