{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:28:40Z","timestamp":1769520520965,"version":"3.49.0"},"reference-count":19,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openrespiratorymedicinejournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORMJ"],"published-print":{"date-parts":[[2019,4,30]]},"abstract":"<jats:sec>\n          <jats:title>Background:<\/jats:title>\n          <jats:p>Tuberculosis prevention is a major goal in the hospital setting. Because of the possible progression or reactivation of latent disease, the screening of healthcare workers is an important issue in the TB control program. The aim of the study was to assess the prevalence of LTBI (latent tuberculosis infection) and to evaluate the main risk factors related to this condition in a teaching hospital in Italy.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Methods:<\/jats:title>\n          <jats:p>We reviewed the data of a tuberculosis screening conducted on 3622 healthcare professionals in a teaching hospital in Rome. All subjects were evaluated by QuantiFERON test which if positive, was followed by appropriate clinical and diagnostic procedures.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results:<\/jats:title>\n          <jats:p>Latent Tuberculosis Infection LTBI condition was detected in 2.1% of the cases, most commonly in men. Male gender, higher age class, country of birth and nurse job were statistically related with the positivity to QuantiFERON test.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusion:<\/jats:title>\n          <jats:p>LTBI was relatively uncommon in our population, however, given the potential risk of reactivation and progression to overt disease, the screening of healthcare workers and students is recommended in the hospital of low-incidence countries.<\/jats:p>\n        <\/jats:sec>","DOI":"10.2174\/1874306401913010001","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T04:32:12Z","timestamp":1557289932000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and Risk Factors for Latent Tuberculosis Infection among Healthcare Workers in a Low Incidence Country"],"prefix":"10.2174","volume":"13","author":[{"given":"Luca","family":"Coppeta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pietroiusti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Neri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Janni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savino","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Papa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Magrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mrm.20517","volume":"54","year":"2005","unstructured":"CDC Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health - Care Settings \n          MMWR  \n          2005; \n\n          54\n          (No. RR-17)\n          : 1-141.","journal-title":"MMWR"},{"key":"ref2","unstructured":"Ministero del Lavoro della Salute e delle Politiche Sociali. \n            Aggiornamento delle raccomandazioni per le attivit\u00e0 di controllo della tubercolosi in Italia \n            2013.\n            http:\/\/www.salute.gov.it\/imgs\/C_17_ pubblicazioni_1221_allegato.pdf"},{"key":"ref3","unstructured":"Istituto Superiore di Sanit\u00e0. \n            Tubercolosi Aspetti epidemiologici: dati generali \n            http:\/\/www.epicentro.iss.it\/problemi\/Tubercolosi\/epid.asp"},{"key":"ref4","first-page":"1","volume":"54","year":"2005","unstructured":"National Tuberculosis Controllers Association; \n            Centers for Disease Control and Prevention (CDC). \n            Guidelines for the investigation of contacts of persons with infectious tuberculosis. Recommendations from the National Tuberculosis Controllers Association and CDC. \n            MMWR Recomm Rep  \n            2005; \n            54\n            (RR-15)\n            : 1-47.","journal-title":"MMWR Recomm. Rep."},{"key":"ref5","unstructured":"Ministero del Lavoro della Salute e delle Politiche Sociali. Prevenzione della tubercolosi negli operatori sanitari e soggetti ad essi equiparati.  Approvato come Accordo nella Conferenza Stato-Regioni-Province Autonome del 7 febbraio 2013"},{"key":"ref6","unstructured":"WHO. \n            WHO policy on TB infection control in health-care facilities, congregate settings and households \n            http:\/\/whqlibdoc.who.int\/ publications\/2009\/9789241598323_eng.pdf"},{"key":"ref7","unstructured":"Decreto legislativo 9 aprile 2008, n. 81 \u201cAttuazione dell\u2019articolo 1 della legge 3 agosto 2007, n. 123, in materia di tutela della salute e della sicurezza nei luoghi di lavoro\u201d."},{"key":"ref8","unstructured":"Conferenza permanente per i rapporti tra lo Stato, le Regioni e le Province Autonome di Trento e Bolzano \u2013 Provvedimento 17 dicembre 1998 \u2013 Linee Guida per il controllo della malattia tubercolare, su proposta del Ministro della Sanit\u00e0, ai sensi dell\u2019art. 115, comma 1, lettera b), del decreto legislativo 31 marzo 1998, n. 112."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1136\/thx.2010.143180","volume":"67","author":"Zwerling A.","year":"2012","unstructured":"Zwerling A, van den Hof S, Scholten J, Cobelens F, Menzies D, Pai M. \n            Interferon-gamma release assays for tuberculosis screening of healthcare workers: A systematic review. \n            Thorax  \n            2012; \n            67\n            (1)\n            : 62-70.","journal-title":"Thorax"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"ofx137","DOI":"10.1093\/ofid\/ofx137","volume":"4","author":"Uden L","year":"2017","unstructured":"Uden L, Barber E, Ford N, Cooke GS. \n            Risk of tuberculosis infection and disease for health care workers: An updated meta-analysis. \n            Open Forum Infect Dis  \n            2017; \n            4\n            (3)\n            : ofx137.","journal-title":"Open Forum Infect Dis."},{"key":"ref11","first-page":"1","author":"Lamberti M.","year":"2016","unstructured":"Lamberti M, Muoio MR, Westermann C, Nienhaus A, Arnese A. \n            RibeiroSobrinho AP, Di Giuseppe G, Garzillo EM, Crispino V, Coppola N, De Rosa A. Prevalence and associated risk factors of latent tuberculosis infection among undergraduate and postgraduate dental students: A retrospective study. \n            Arch Environ Occup Health  \n            2016; \n        \n            1-7.\n            \n            \n           [Epub ahead of print].","journal-title":"Arch. Environ. Occup. Health"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6673-4-1","volume":"4","author":"Schablon A.","year":"2009","unstructured":"Schablon A, Beckmann G, Harling M, Diel R, Nienhaus A. \n            Prevalence of latent tuberculosis infection among health care workers in a hospital for pulmonary diseases. \n            J Occup Med Toxicol  \n            2009; \n            4\n            : 1.","journal-title":"J. Occup. Med. Toxicol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1128\/JCM.02803-15","volume":"54","author":"Banaei N.","year":"2016","unstructured":"Banaei N, Gaur RL, Pai M. \n            M. PaiInterferon \u03b3 release assays for latent tuberculosis: What are the sources of variability? \n            J Clin Microbiol  \n            2016; \n            54\n            (4)\n            : 845-50.","journal-title":"J. Clin. Microbiol."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115322","volume":"9","author":"Schablon A.","year":"2014","unstructured":"Schablon A, Nienhaus A, Ringshausen FC, Preisser AM, Peters C. \n            Occupational screening for tuberculosis and the use of a borderline zone for interpretation of the IGRA in German healthcare workers. \n            PLoS One  \n            2014; \n            9\n            (12)\n            e115322","journal-title":"PLoS One"},{"key":"ref15","first-page":"137","volume":"72","author":"Magrini A.","year":"2016","unstructured":"Magrini A, Coppeta L, Somma G, et al. \n            Risk of tuberculosis in healthcare workers: Risk assessment and medical surveillance. \n            Ig Sanita Pubbl  \n            2016; \n            72\n            (2)\n            : 137-43.","journal-title":"Ig. Sanita Pubbl."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/imm.12223","volume":"141","author":"Verrall A.J.","year":"2014","unstructured":"Verrall AJ, Netea MG, Alisjahbana B, Hill PC, van Crevel R. \n            Early clearance of Mycobacterium tuberculosis: A new frontier in prevention. \n            Immunology  \n            2014; \n            141\n            (4)\n            : 506-13.","journal-title":"Immunology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1164\/rccm.200607-923ED","volume":"174","author":"Nardell E.A.","year":"2006","unstructured":"Nardell EA, Wallis RS. \n            Here today gone tomorrow: The case for transient acute tuberculosis infection. \n            Am J Respir Crit Care Med  \n            2006; \n            174\n            (7)\n            : 734-5.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1186\/1471-2334-13-443","volume":"13","author":"Durando P.","year":"2013","unstructured":"Durando P, Sotgiu G, Spigno F, et al. \n            Latent tuberculosis infection and associated risk factors among undergraduate healthcare students in Italy: A cross-sectional study. \n            BMC Infect Dis  \n            2013; \n            13\n            : 443.","journal-title":"BMC Infect. Dis."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/746895","volume":"2015","author":"Durando P.","year":"2015","unstructured":"Durando P, Alicino C, Orsi A, et al. \n            Latent tuberculosis infection among a large cohort of medical students at a teaching hospital in Italy. \n            BioMed Res Int  \n            2015; \n            2015\n            746895","journal-title":"BioMed Res. Int."}],"container-title":["The Open Respiratory Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openrespiratorymedicinejournal.com\/contents\/volumes\/V13\/TORMJ-13-1\/TORMJ-13-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrespiratorymedicinejournal.com\/contents\/volumes\/V13\/TORMJ-13-1\/TORMJ-13-1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrespiratorymedicinejournal.com\/contents\/volumes\/V13\/TORMJ-13-1\/TORMJ-13-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T04:32:16Z","timestamp":1557289936000},"score":1,"resource":{"primary":{"URL":"https:\/\/openrespiratorymedicinejournal.com\/VOLUME\/13\/PAGE\/1\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,4,30]]}},"alternative-id":["TORMJ-13-1"],"URL":"https:\/\/doi.org\/10.2174\/1874306401913010001","relation":{},"ISSN":["1874-3064"],"issn-type":[{"value":"1874-3064","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4,30]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}