{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:40:42Z","timestamp":1761561642754,"version":"build-2065373602"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openrheumatologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORJ"],"published-print":{"date-parts":[[2012,6,28]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine associations between sicca symptoms, chronic rhinosinusitis (CRS) symptoms and asthma in a community survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data was obtained from the Spring 2009 South Australian Health Omnibus Survey which sampled,\n                      <jats:italic>via<\/jats:italic>\n                      interviewer administered questionnaire, 3007 individuals aged 15 years and over whose socio-demographic distribution corresponded to South Australian population estimates. Respondents were asked a range of questions relating to the presence of persistent dry eyes or dry mouth, CRS and medically diagnosed nasal polyps and asthma. Relationships between symptoms were explored using maximum likelihood dependency tree analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The respective population prevalences were: dry mouth (5.9%), dry eyes (8.6%), nasal polyps (3.8%), CRS (13.2%) and asthma (12.0%). The overall prevalence of sicca symptoms (dry eyes or dry mouth) was 12.4%. Dependency tree analysis revealed the expected symptom clustering between (1) sicca symptoms and their association with female gender and increasing age and (2) CRS, nasal polyps and asthma (one airway hypothesis). However there was also an association between dry eyes and CRS (OR 2.5, 95% CI 1.9, 3.4), which was in fact stronger than the association between CRS and asthma (OR 1.9, 95% CI 1.4, 2.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Sicca symptoms are common in the community. Our novel finding of a strong association between dry eyes and CRS suggests that further research into the relationship between airway inflammation and sicca symptoms is required. These findings may have particular relevance to Sj\u00f6gren\u2019s syndrome (SS) in both its primary and secondary forms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874312901206010170","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T11:04:47Z","timestamp":1341486287000},"page":"170-174","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sicca Symptoms and their Association with Chronic Rhinosinusitis in a Community Sample"],"prefix":"10.2174","volume":"6","author":[{"given":"S","family":"Lester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rischmueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LW","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PJ","family":"Wormald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Zalewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MA","family":"Hamilton-Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RJ","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/03009740701678712","volume":"37","author":"Haugen AJ","year":"2008","unstructured":"Haugen AJ, Peen E, Hulten B, et al. \n                Estimation of the prevalence\nof primary Sjogren's syndrome in two age-different community-based\npopulations using two sets of classification criteria: the\nHordaland Health Study \n                Scand J Rheumatol  \n                2008; \n                37\n                (1)\n                : 30-4.","journal-title":"Scand J Rheumatol"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1196\/annals.1384.003","volume":"1098","author":"Fox PC","year":"2007","unstructured":"Fox PC. \n                Autoimmune diseases and Sjogren's syndrome: an\nautoimmune exocrinopathy \n                Ann N Y Acad Sci  \n                2007; \n                1098\n                : 15-21.","journal-title":"Ann N Y Acad Sci"},{"key":"refR3","unstructured":"Sjogren HSC. \n                A new conception of keratoconjunctivitis sicca:\nkeratitis filiformis in hypofunction of the lachrymal glands. \n                Sydney: Australasian Medical Publishing 1943."},{"key":"refR4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/bmj.4.5785.460","volume":"4","author":"Doig JA","year":"1971","unstructured":"Doig JA, Whaley K, Dick WC, et al. \n                Otolaryngological aspects of\nSjogren's syndrome \n                Br Med J  \n                1971; \n                4\n                (5785)\n                : 460-3.","journal-title":"Br Med J"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2214\/ajr.169.3.9275871","volume":"169","author":"Franquet T","year":"1997","unstructured":"Franquet T, Gimenez A, Monill JM, et al. \n                Primary Sjogren's\nsyndrome and associated lung disease: CT findings in 50 patients \n                AJR Am J Roentgenol  \n                1997; \n                169\n                (3)\n                : 655-8.","journal-title":"AJR Am J Roentgenol"},{"key":"refR6","first-page":"125","volume":"9","author":"La Corte R","year":"1991","unstructured":"La Corte R, Potena A, Bajocchi G, et al. \n                Increased bronchial\nresponsiveness in primary Sjogren's syndrome. 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