{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:56:30Z","timestamp":1772160990085,"version":"3.50.1"},"reference-count":18,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T00:00:00Z","timestamp":1353024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openrheumatologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORJ"],"published-print":{"date-parts":[[2012,11,16]]},"abstract":"<jats:p>Felty\u2019s syndrome is a rare, severe extra-articular manifestation of rheumatoid arthritis (RA). There is no standard therapy, and several disease-modifying antirheumatic drugs have been used with varying success. Only very few reports exist in literature on the use of biologicals in this indication and this with a variable efficacy. We report the case of a 53-year-old woman with severe refractory\/partly undertreated RA who presented with Felty\u2019s syndrome and pancytopenia, in whom treatment with rituximab led to an marked increase of red blood cells, neutrophils and thrombocytes. In addition, the RA disease activity status improved dramatically and treatment with steroids could be reduced. The current sparse literature on this topic is reviewed.<\/jats:p>","DOI":"10.2174\/1874312901206010312","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T04:11:12Z","timestamp":1353557472000},"page":"312-314","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeted Therapy with Rituximab in Felty\u2019s Syndrome: A Case Report"],"prefix":"10.2174","volume":"6","author":[{"given":"Line","family":"Heylen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan","family":"Dierickx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Westhovens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.berh.2004.05.002","volume":"18","author":"Balint GP","year":"2004","unstructured":"Balint GP, Balint PV. \n            Felty's syndrome \n            Best Pract Res Clin Rheumatol  \n            2004; \n            18\n            : 631-45.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00005792-199069020-00001","volume":"69","author":"Campion G","year":"1990","unstructured":"Campion G, Maddison PJ, Goulding N, et al. \n            The Felty syndrome\na case-matched study of clinical manifestations and outcome\nserologic features and immunogenetic associations \n            Medicine\n(Baltimore)  \n            1990; \n            69\n            : 69-80.","journal-title":"Medicine\n(Baltimore)"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/ard.41.5.486","volume":"41","author":"Thorne C","year":"1982","unstructured":"Thorne C, Urowitz MB. \n            Long-term outcome in Felty's syndrome \n            \nAnn Rheum Dis  \n            1982; \n            41\n            : 486-9.","journal-title":"Ann Rheum Dis"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1200\/JCO.1997.15.10.3266","volume":"15","author":"Maloney DG","year":"1997","unstructured":"Maloney DG, Grillo-Lopez AJ, Bodkin DJ, et al. \n            IDEC-C2B8\nresults of a phase I multiple-dose trial in patients with relapsed\nnon-Hodgkin's lymphoma \n            J Clin Oncol  \n            1997; \n            15\n            : 3266-74.","journal-title":"J Clin Oncol"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1200\/JCO.1998.16.8.2825","volume":"16","author":"McLaughlin P","year":"1998","unstructured":"McLaughlin P, Grillo-Lopez AJ, Link BK, et al. \n            Rituximab\nchimeric anti-CD20 monoclonal antibody therapy for relapsed\nindolent lymphoma: half of patients respond to a four-dose\ntreatment program \n            J Clin Oncol  \n            1998; \n            16\n            : 2825-33.","journal-title":"J Clin Oncol"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/rheumatology\/38.11.1150","volume":"38","author":"Protheroe A","year":"1999","unstructured":"Protheroe A, Edwards JC, Simmons A, Maclennan K, Selby P. \n            \nRemission of inflammatory arthropathy in association with anti-\nCD20 therapy for non-Hodgkin's lymphoma \n            Rheumatology\n(Oxford)  \n            1999; \n            38\n            : 1150-2.","journal-title":"Rheumatology\n(Oxford)"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1056\/NEJMoa032534","volume":"350","author":"Edwards JC","year":"2004","unstructured":"Edwards JC, Szczepanski L, Szechinski J, et al. \n            Efficacy of B-celltargeted\ntherapy with rituximab in patients with rheumatoid\narthritis \n            N Engl J Med  \n            2004; \n            350\n            : 2572-81.","journal-title":"N Engl J Med"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1002\/art.22025","volume":"54","author":"Cohen SB","year":"2006","unstructured":"Cohen SB, Emery P, Greenwald MW, et al. \n            Rituximab for\nrheumatoid arthritis refractory to anti-tumor necrosis factor\ntherapy: Results of a multicenter randomized double-blind\nplacebo-controlled phase III trial evaluating primary efficacy and\nsafety at twenty-four weeks \n            Arthritis Rheum  \n            2006; \n            54\n            : 2793-806.","journal-title":"Arthritis Rheum"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/ard.34.2.156","volume":"34","author":"Gupta R","year":"1975","unstructured":"Gupta R, Robinson WA, Albrecht D. \n            Granulopoietic activity in\nFelty's syndrome \n            Ann Rheum Dis  \n            1975; \n            34\n            : 156-61.","journal-title":"Ann Rheum Dis"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/art.1780180405","volume":"18","author":"Duckham DJ","year":"1975","unstructured":"Duckham DJ, Rhyne RL Jr, Smith FE, Williams RC  Jr. \n            Retardation\nof colony growth of in vitro bone marrow culture using sera from\npatients with Felty's syndrome disseminated lupus erythematosus\n(SLE) rheumatoid arthritis and other disease states \n            Arthritis\nRheum  \n            1975; \n            18\n            : 323-3.","journal-title":"Arthritis\nRheum"},{"key":"refR11","first-page":"1127","volume":"26","author":"Wiik A","year":"1974","unstructured":"Wiik A, Munthe E. \n            Complement-fixing granulocyte-specific\nantinuclear factors in neutropenic cases of rheumatoid arthritis \n            \nImmunology  \n            1974; \n            26\n            : 1127-34.","journal-title":"Immunology"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2141.2010.08076.x","volume":"149","author":"Cooper N","year":"2010","unstructured":"Cooper N, Arnold DM. \n            The effect of rituximab on humoral and cell\nmediated immunity and infection in the treatment of autoimmune\ndiseases \n            Br J Haematol  \n            2010; \n            149\n            : 3-13.","journal-title":"Br J Haematol"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ajh.21939","volume":"86","author":"Dierickx D","year":"2011","unstructured":"Dierickx D, Delannoy A, Saja K, Verhoef G, Provan D. \n            Anti-CD20\nmonoclonal antibodies and their use in adult autoimmune\nhematological disorders \n            Am J Hematol  \n            2011; \n            86\n            : 278-91.","journal-title":"Am J Hematol"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.rhu.0000200326.17729.76","volume":"12","author":"Weinreb N","year":"2006","unstructured":"Weinreb N, Rabinowitz A, Dellaripa PF. \n            Beneficial response to\nrituximab in refractory Felty Syndrome \n            J Clin Rheumatol  \n            2006; \n            \n12\n            : 48.","journal-title":"J Clin Rheumatol"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/ard.2007.077966","volume":"67","author":"Salama A","year":"2008","unstructured":"Salama A, Schneider U, Dorner T. \n            Beneficial response to rituximab\nin a patient with haemolysis and refractory Felty syndrome \n            Ann\nRheum Dis  \n            2008; \n            67\n            : 894-5.","journal-title":"Ann\nRheum Dis"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1136\/ard.2007.078915","volume":"67","author":"Lekharaju V","year":"2008","unstructured":"Lekharaju V, Chattopadhyay C. \n            Efficacy of rituximab in Felty's\nsyndrome \n            Ann Rheum Dis  \n            2008; \n            67\n            : 1352.","journal-title":"Ann Rheum Dis"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/ard.2004.025643","volume":"64","author":"Sordet C","year":"2005","unstructured":"Sordet C, Gottenberg JE, Hellmich B, Kieffer P, Mariette X, Sibilia \nJ. \n            Lack of efficacy of rituximab in Felty's syndrome \n            Ann Rheum\nDis  \n            2005; \n            64\n            : 332-.","journal-title":"Ann Rheum\nDis"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/art.1780290713","volume":"7","author":"Allen LS","year":"1986","unstructured":"Allen LS, Groff G. \n            Treatment of Felty's syndrome with low-dose\noral methotrexate \n            Arthritis Rheum  \n            1986; \n            7\n            : 902-5.","journal-title":"Arthritis Rheum"}],"container-title":["The Open Rheumatology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V6\/TORJ-6-312\/TORJ-6-312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V6\/TORJ-6-312\/TORJ-6-312.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V6\/TORJ-6-312\/TORJ-6-312.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:11:06Z","timestamp":1761559866000},"score":1,"resource":{"primary":{"URL":"https:\/\/openrheumatologyjournal.com\/VOLUME\/6\/PAGE\/312\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,16]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,11,16]]}},"alternative-id":["TORJ-6-312"],"URL":"https:\/\/doi.org\/10.2174\/1874312901206010312","relation":{},"ISSN":["1874-3129"],"issn-type":[{"value":"1874-3129","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11,16]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2012-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}