{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:33:26Z","timestamp":1787585606698,"version":"build-2736575974"},"reference-count":94,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["openrheumatologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORJ"],"published-print":{"date-parts":[[2015,12,22]]},"abstract":"<jats:p>Inflammatory rheumatic diseases are characterized by inflammation resulting from the immune dysregulation\nthat usually attacks joints, skin and internal organs. Many of them are considered as complex disease that may be\npredisposed by multiple genes and\/or genetic loci, and triggered by environmental factors such as microbiome and cellular\nstress. The major histocompatibility complex class I chain-related gene A (MICA) is a highly polymorphic gene that\nencodes protein variants expressed under cellular stress conditions, and these MICA variants play important roles in\nimmune activation and surveillance. Recently, accumulating evidences from both genetic and functional studies have\nsuggested that MICA polymorphisms may be associated with various rheumatic diseases, and the expression of MICA\nvariants may attribute to the altered immune responses in the diseases. The objective of this review is to discuss potential\ngenetic associations and pathological relevance of MICA in inflammatory rheumatic diseases that may help us to\nunderstand pathogenesis contributing to the development of these diseases.    <\/jats:p>","DOI":"10.2174\/1874312901409010094","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T10:39:20Z","timestamp":1450780760000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases"],"prefix":"10.2174","volume":"9","author":[{"given":"Qingwen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"publisher","first-page":"6259","DOI":"10.1073\/pnas.91.14.6259","volume":"91","author":"Bahram S.","year":"1994","unstructured":"Bahram S, Bresnahan M, Geraghty DE, Spies T. \n            A second lineage of mammalian major histocompatibility complex class I genes \n            Proc Natl Acad Sci USA  \n            1994; \n            91\n            (14)\n            : 6259-63.","journal-title":"Proc. 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