{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:23:08Z","timestamp":1790234588240,"version":"4.1.0"},"reference-count":40,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openrheumatologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORJ"],"published-print":{"date-parts":[[2017,1,31]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To study the association between\n                      <jats:italic>ERAP1<\/jats:italic>\n                      ,\n                      <jats:italic>IL23R<\/jats:italic>\n                      and\n                      <jats:italic>PTGER4<\/jats:italic>\n                      single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      rs27044 and rs30187 (\n                      <jats:italic>ERAP1<\/jats:italic>\n                      ), rs11209032 (\n                      <jats:italic>IL23R<\/jats:italic>\n                      ) and rs10440635 (\n                      <jats:italic>PTGER4<\/jats:italic>\n                      ) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of \u201c0\u201d following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of &gt;20 (patients with mild vertebral changes (\n                      <jats:italic>i.e.<\/jats:italic>\n                      squaring or erosions) were omitted for clear stratification) regardless of disease duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The genotype distributions and allele frequencies of\n                      <jats:italic>ERAP1<\/jats:italic>\n                      rs27044 and rs30187,\n                      <jats:italic>IL23R<\/jats:italic>\n                      rs11209032 and\n                      <jats:italic>PTGER4<\/jats:italic>\n                      rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5\u00b117.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In radiographically well-categorized AS patients,\n                      <jats:italic>ERAP1<\/jats:italic>\n                      rs27044 and rs30187,\n                      <jats:italic>IL23R<\/jats:italic>\n                      rs11209032 and\n                      <jats:italic>PTGER4<\/jats:italic>\n                      rs10440635 SNPs are not found to be associated with radiographic severity of AS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874312901711010001","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T01:03:50Z","timestamp":1486688630000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis"],"prefix":"10.2174","volume":"11","author":[{"given":"Gulsen","family":"Ozen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Eren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Erzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Ugur","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel Zehra","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevsun","family":"Inanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamir","family":"Atagunduz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1136\/annrheumdis-2011-200842","volume":"71","author":"Lories R.J.","year":"2012","unstructured":"Lories RJ, Dougados M. 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