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The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IRF8, TNFAIP3, REL, TLR4, NOD1,2, CCR1,CCR3, GIMAP1,2,4, KLRC4, STAT4, NCOA5, FOXP3, PSORS1C1, FUT2, UBAC2, SUMO4, ADO-EGR2, CEBPB-PTPN1, and JPKL-CNTN5. These genes encode proteins involved mainly in immune regulation and inflammation, and some in transcription and post-translational modification. A complete view of these BD-associated genes may provide a clue to this complex disease in terms of its pathogenesis and exploring potentially targeted therapies for BD.<\/jats:p>","DOI":"10.2174\/1874312901812010070","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T11:09:45Z","timestamp":1530788985000},"page":"70-85","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review"],"prefix":"10.2174","volume":"12","author":[{"given":"Yan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1750-1172-7-20","volume":"12","author":"Saadoun D","year":"2012","unstructured":"Saadoun D, Wechsler B. 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