{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:31:44Z","timestamp":1761129104429},"reference-count":17,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openrheumatologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORJ"],"published-print":{"date-parts":[[2013,11,29]]},"abstract":"<jats:sec>\n                <jats:title>Objectives:<\/jats:title>\n                <jats:p> The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA.\n<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n                <jats:title>Methods: <\/jats:title>\n                <jats:p>We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI) were performed on all cases, and pain was assessed with the Denis pain scale. Average age, height, weight, body mass index, bone mineral density (L1-4), central edge angle, Sharp\u2019s angle, and acetabular hip index were calculated.\n<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n                <jats:title>Results: <\/jats:title>\n                <jats:p>Within two months of the onset of pain, 4 of the 7 cases showed broad bone signal changes, while 3 cases showed local signal changes in the proximal femur on hip MRI. Three to 6 months after the onset of pain, in all patients whose pain was much improved, plain radiographs showed progression to further-stage OA.\n<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n                <jats:title>Conclusion: <\/jats:title>\n                <jats:p>Our findings suggest that bone abnormalities in the proximal femur might be involved in the pathogenesis of primary hip OA.\n<\/jats:p> <\/jats:sec>","DOI":"10.2174\/1874312920130930003","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T00:13:01Z","timestamp":1381709581000},"page":"112-118","update-policy":"http:\/\/dx.doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations"],"prefix":"10.2174","volume":"7","author":[{"given":"Mikio","family":"Kamimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijiro","family":"Mukaiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeharu","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","first-page":"34","volume":"213","author":"Radin EL","year":"1986","unstructured":"Radin EL, Rose RM. \n                    Role of subchondral bone in the initiation and progression of cartilage damage. \n                    Clin Orthop Relat Res  \n                    1986; \n                     213\n                    : 34-40.","journal-title":"Clin Orthop Relat Res"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","volume":"8","author":"Burr DB","year":"2012","unstructured":"Burr DB, Gallant MA. \n                    Bone remodelling in osteoarthritis. \n                    Nat Rev Rheumatol  \n                    2012; \n                     8\n                    : 665-73.","journal-title":"Nat Rev Rheumatol"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nrrheum.2012.223","volume":"9","author":"Guermazi A","year":"2013","unstructured":"Guermazi A, Roemer FW, Haugen IK, Crema MD, Hayashi D. \n                    MRI-based semiquantitative scoring of joint pathology in osteoarthritis. \n                    Nat Rev Rheumatol  \n                    2013; \n                     9\n                    : 236-51.","journal-title":"Nat Rev Rheumatol"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semarthrit.2012.03.009","volume":"42","author":"Xu L","year":"2012","unstructured":"Xu L, Hayashi D, Roemer FW, Felson DT, Guermazi A. \n                    Magnetic resonance imaging of subchondral bone marrow lesions in association with osteoarthritis. \n                    Semin Arthritis Rheum  \n                    2012; \n                     42\n                    : 105-8.","journal-title":"Semin Arthritis Rheum"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"e5339","DOI":"10.1136\/bmj.e5339","volume":"345","author":"Guermazi A","year":"2012","unstructured":"Guermazi A, Niu J, Hayashi D, et al. \n                    Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). \n                    BMJ  \n                    2012; \n                    345\n                    : e5339-0.","journal-title":"BMJ"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2174\/1874312901307010058","volume":"7","author":"Kamimura M","year":"2013","unstructured":"Kamimura M, Nakamura Y, Ikegami S, Uchiyama S, Kato H. \n                    Joint pain undergoes a transition in accordance with signal changes of bones detected by MRI in hip osteoarthritis. \n                    Open Rheumatol J  \n                    2013; \n                     7\n                    : 58-65.","journal-title":"Open Rheumatol J"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.joca.2009.04.005","volume":"17","author":"Muraki S","year":"2009","unstructured":"Muraki S, Oka H, Akune T, et al. \n                    Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. \n                    Osteoarth Cartil  \n                    2009; \n                     17\n                    : 1137-43.","journal-title":"Osteoarth Cartil"},{"key":"refR8","first-page":"142","volume":"189","author":"Denis F","year":"1984","unstructured":"Denis F, Armstrong GW, Searls K, Matta L. \n                    Acute thoracolumbar burst fractures in the absence of neurologic deficit.A comparison between operative and nonoperative treatment. \n                     Clin Orthop Relat Res  \n                    1984; \n                     189\n                    : 142-9.","journal-title":"Clin Orthop Relat Res"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jocn.2005.11.050","volume":"14","author":"Takahara K","year":"2007","unstructured":"Takahara K, Kamimura M, Nakagawa H, Hashidate H, Uchiyama S. \n                    Radiographic evaluation of vertebral fractures in osteoporotic patients. \n                    J Clin Neurosci  \n                    2007; \n                    14\n                    : 122-6.","journal-title":"J Clin Neurosci"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2214\/ajr.147.3.553","volume":"147","author":"Stafford SA","year":"1986","unstructured":"Stafford SA, Rosenthal DI, Gebhardt MC, Brady TJ, Scott JA. \n                    MRI in stress fracture. \n                    AJR Am J Roentgenol  \n                    1986; \n                     147\n                    : 553-6.","journal-title":"AJR Am J Roentgenol"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1148\/radiology.167.3.3363134","volume":"167","author":"Yao L","year":"1988","unstructured":"Yao L, Lee JK. \n                    Occult intraosseous fracture: detection with MR imaging. \n                    Radiology  \n                    1988; \n                     167\n                    : 749-51.","journal-title":"Radiology"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1097-0029(19970515)37:4<343::AID-JEMT9>3.0.CO;2-L","volume":"37","author":"Burr DB","year":"1997","unstructured":"Burr DB, Schaffler MB. \n                    The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence. \n                    Microsc Res Tech  \n                    1997; \n                    37\n                    : 343-57.","journal-title":"Microsc Res Tech"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00002281-199805000-00017","volume":"10","author":"Burr DB","year":"1998","unstructured":"Burr DB. \n                    The importance of subchondral bone in osteoarthrosis. \n                    Curr Opin Rheumatol  \n                    1998; \n                     10\n                    : 256-62.","journal-title":"Curr Opin Rheumatol"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0889-857X(03)00061-9","volume":"29","author":"Burr DB","year":"2003","unstructured":"Burr DB, Radin EL. \n                    Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?. \n                    Rheum Dis Clin North Am  \n                    2003; \n                    29\n                    : 675-85.","journal-title":"Rheum Dis Clin North Am"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/art.20124","volume":"50","author":"Hayami T","year":"2004","unstructured":"Hayami T, Pickarski M, Wesolowski GA, et al. \n                    The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. \n                    Arthritis Rheum  \n                    2004; \n                    50\n                    : 193-206.","journal-title":"Arthritis Rheum."},{"key":"refR16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3349\/ymj.2010.51.2.164","volume":"51","author":"Iwamoto J","year":"2010","unstructured":"Iwamoto J, Takeda T, Sato Y, Matsumoto H. \n                    Effects of risedronate on osteoarthritis of the knee. \n                    Yonsei Med J  \n                    2010; \n                    51\n                    : 164-70.","journal-title":"Yonsei Med J."},{"key":"refR17","doi-asserted-by":"crossref","first-page":"R152","DOI":"10.1186\/ar3103","volume":"12","author":"Bellido M","year":"2010","unstructured":"Bellido M, Lugo L, Roman-Blas JA, et al. \n                    Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. \n                    Arthritis Res Ther  \n                    2010; \n                    12\n                    (4\n                    )\n                    : R152-0.","journal-title":"Arthritis Res Ther"}],"container-title":["The Open Rheumatology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V7\/TORJ-7-112\/TORJ-7-112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V7\/TORJ-7-112\/TORJ-7-112.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V7\/TORJ-7-112\/TORJ-7-112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T01:54:27Z","timestamp":1561082067000},"score":1,"resource":{"primary":{"URL":"https:\/\/openrheumatologyjournal.com\/VOLUME\/7\/PAGE\/112\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,11,29]]}},"alternative-id":["TORJ-7-112"],"URL":"https:\/\/doi.org\/10.2174\/1874312920130930003","relation":{},"ISSN":["1874-3129"],"issn-type":[{"value":"1874-3129","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2013-8-9","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-9-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-9-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}