{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:54:47Z","timestamp":1791395687250,"version":"4.3.3"},"reference-count":28,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openrheumatologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TORJ"],"published-print":{"date-parts":[[2013,11,29]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p> Determine risk factors for infection following hip or knee total joint arthroplasty in patients with\nrheumatoid arthritis.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Methods: <\/jats:title>\n                    <jats:p>All rheumatoid arthritis patients with a hip or knee arthroplasty between years 2000 and 2010 were identified\nfrom population-based administrative data from the Calgary Zone of Alberta Health Services. Clinical data from patient\ncharts during the hospital admission and during a one year follow-up period were extracted to identify incident infections.\n<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Results: <\/jats:title>\n                    <jats:p>We identified 381 eligible procedures performed in 259 patients (72.2% female, mean age 63.3 years, mean body\nmass index 27.6 kg\/m2). Patient comorbidities were hypertension (43.2%), diabetes (10.4%), coronary artery disease\n(13.9%), smoking (10.8%) and obesity (32%). Few infectious complications occurred: surgical site infections occurred\nwithin the first year after 5 procedures (2 joint space infections, 3 deep incisional infections). Infections of non-surgical\nsites (urinary tract, skin or respiratory, n=4) complicated the hospital admission. The odds ratio for any post-arthroplasty\ninfection was increased in patients using prednisone doses exceeding 15 mg\/day (OR 21.0, 95%CI 3.5-127.2, p=&lt;0.001),\nunderweight patients (OR 6.0, 95%CI 1.2-30.9, p=0.033) and those with known coronary artery disease (OR 5.1, 95%CI\n1.3-19.8, p=0.017). Types of disease-modifying therapy, age, sex, and other comorbidities were not associated with an\nincreased risk for infection.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Conclusion: <\/jats:title>\n                    <jats:p>Steroid doses over 15 mg\/day, being underweight and having coronary artery disease were associated with\nsignificant increases in the risk of post-arthroplasty infection in rheumatoid arthritis. Maximal tapering of prednisone and\ncomorbidity risk reduction must be addressed in the peri-operative management strategy.\n<\/jats:p>\n                <\/jats:sec>","DOI":"10.2174\/1874312920131210005","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T05:53:15Z","timestamp":1389592395000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Risk Factors for Infection Following Total Joint Arthroplasty in Rheumatoid Arthritis"],"prefix":"10.2174","volume":"7","author":[{"given":"Ranjani","family":"Somayaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Barnabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","first-page":"52","volume":"29","author":"Massardo L","year":"2002","unstructured":"Massardo L, Gabriel SE, Crowson CS. \n                    A population based assessment of the use of orthopedic surgery in patients with rheumatoid arthritis. \n                    J Rheumatol  \n                    2002; \n                    29\n                    (1)\n                    : 52-6.","journal-title":"J Rheumatol"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/art.10998","volume":"49","author":"da Silva E","year":"2003","unstructured":"da Silva E, Doran MF, Crowson CS. \n                    Declining use of orthopedic surgery in patients with rheumatoid arthritis?.Results of a long-erm.population-based assessment. \n                    Arthritis Rheum  \n                    2003; \n                     49 \n                    (2)\n                    : 216-0.","journal-title":"Arthritis Rheum"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/ard.2009.112474","volume":"69","author":"Louie GH","year":"2010","unstructured":"Louie GH, Ward MM. \n                    Changes in the rates of joint surgery among patients with rheumatoid arthritis in California. 1983-2007. \n                     Ann Rheum Dis  \n                    2010; \n                    69\n                    (5)\n                    : 868-7.","journal-title":"Ann Rheum Dis"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1186\/ar3328","volume":"13","author":"Hekmat K","year":"2011","unstructured":"Hekmat K, Jacobsson L, Nilsson JA. \n                    Decrease in the incidence of total hip arthroplasties in patients with rheumatoid arthritis--results from a well defined population in south Sweden. \n                    Arthritis Res Ther  \n                    2011; \n                    13\n                    (2)\n                    : R67.","journal-title":"Arthritis Res Ther"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3899\/jrheum.111056","volume":"39","author":"Shourt CA","year":"2012","unstructured":"Shourt CA, Crowson CS, Gabriel SE. \n                    Orthopedic surgery among patients with rheumatoid arthritis 1980-2007 a population-based study focused on surgery rates sex and mortality. \n                    J Rheumatol  \n                    2012; \n                    39\n                    (3)\n                    : 481-5.","journal-title":"J Rheumatol"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1002\/art.37690","volume":"64","author":"Ravi B","year":"2012","unstructured":"Ravi B, Escott B, Shah PS. \n                    A systematic review and meta-analysis comparing complications following total joint arthroplasty for rheumatoid arthritis versus for osteoarthritis. \n                    Arthritis Rheum  \n                    2012; \n                    64\n                    (12)\n                    : 3839-49.","journal-title":"Arthritis Rheum"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1017\/S0195941700015241","volume":"13","author":"Horan TC","year":"1992","unstructured":"Horan TC, Gaynes RP, Martone WJ. \n                    CDC definitions of nosocomial surgical site infections. 1992: a modification of CDC definitions of surgical wound infections. \n                     Infect Control Hosp Epidemiol  \n                    1992; \n                    13\n                    (10)\n                    : 606-8.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1002\/art.34530","volume":"64","author":"Crowson CS","year":"2012","unstructured":"Crowson CS, Hoganson DD, Fitz-Gibbon PD. \n                    Development and validation of a risk score for serious infection in patients with rheumatoid arthritis. \n                    Arthritis Rheum  \n                    2012; \n                    64\n                    (9)\n                    : 2847-55.","journal-title":"Arthritis Rheum"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/art.24060","volume":"59","author":"Bongartz T","year":"2008","unstructured":"Bongartz T, Halligan CS, Osmon DR. \n                    Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. \n                    Arthritis Rheum  \n                    2008; \n                    59\n                    (12)\n                    : 1713-20.","journal-title":"Arthritis Rheum"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/17453679108994458","volume":"62","author":"Bengtson S","year":"1991","unstructured":"Bengtson S, Knutson K. \n                    The infected knee arthroplasty.A 6-year follow-up of 357 cases. \n                     Acta Orthop Scand  \n                    1991; \n                    62\n                    (4)\n                    : 301-11.","journal-title":"Acta Orthop Scand"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/000164701753532853","volume":"72","author":"Robertsson O","year":"2001","unstructured":"Robertsson O, Knutson K, Lewold S. \n                    The Swedish Knee Arthroplasty Register 1975-1997: an update with special emphasis on 41 223 knees operated on in 1988-1997. \n                    Acta Orthop Scand  \n                    2001; \n                    72\n                    (5)\n                    : 503-13.","journal-title":"Acta Orthop Scand"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"878","DOI":"10.2106\/00004623-199072060-00013","volume":"72","author":"Wilson MG","year":"1990","unstructured":"Wilson MG, Kelley K, Thornhill TS. \n                    Infection as a complication of total knee-replacement arthroplasty.Risk factors and treatment in sixty-seven cases. \n                     J Bone Joint Surg Am  \n                    1990; \n                    72\n                    (6)\n                    : 878-3.","journal-title":"J Bone Joint Surg Am"},{"key":"refR13","first-page":"665","volume":"63","author":"Wymenga AB","year":"1992","unstructured":"Wymenga AB, van Horn JR, Theeuwes A. \n                    Perioperative factors associated with septic arthritis after arthroplasty.Prospective multicenter study of 362 knee ad 2.51 hip operations.  \n                    Acta Orthop Scand  \n                    1992; \n                    63\n                    (6)\n                    : 665-71.","journal-title":"Acta Orthop Scand"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1086\/514991","volume":"27","author":"Berbari EF","year":"1998","unstructured":"Berbari EF, Hanssen AD, Duffy MC. \n                    Risk factors for prosthetic joint infection: case-control study. \n                    Clin Infect Dis  \n                    1998; \n                    27\n                    (5)\n                    : 1247-54.","journal-title":"Clin Infect Dis"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2106\/JBJS.G.01686","volume":"91","author":"Jamsen E","year":"2009","unstructured":"Jamsen E, Huhtala H, Puolakka T, et al. \n                    Risk factors for infection after knee arthroplasty A register-based analysis of 43 149 cases. \n                    J Bone Joint Surg Am  \n                    2009; \n                    91\n                    (1)\n                    : 38-47.","journal-title":"J Bone Joint Surg Am"},{"key":"refR16","author":"Saucedo JM","year":"2013","unstructured":"Saucedo JM, Marecek GS, Wanke TR, et al. \n                    Understanding Readmission After Primary Total Hip and Knee Arthroplasty Who's at Risk?. \n                    J Arthroplasty  [Epub ahead of print] \n                    2013.","journal-title":"J Arthroplasty  [Epub ahead of print]."},{"key":"refR17","doi-asserted-by":"crossref","first-page":"R145","DOI":"10.1186\/ar3087","volume":"12","author":"Gilson M","year":"2010","unstructured":"Gilson M, Gossec L, Mariette X, et al. \n                    Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor alpha-blockers: a case-control study. \n                    Arthritis Res Ther  \n                    2010; \n                    12\n                    (4)\n                    : R145.","journal-title":"Arthritis Res Ther"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/rheumatology\/kep376","volume":"49","author":"Kawakami K","year":"2010","unstructured":"Kawakami K, Ikari K, Kawamura K, et al. \n                    Complications and features after joint surgery in rheumatoid arthritis patients treated with tumour necrosis factor-alpha blockers: perioperative interruption of tumour necrosis factor-alpha blockers decreases complications?. \n                    Rheumatology (Oxford)  \n                    2010; \n                    49\n                    (2)\n                    : 341-7.","journal-title":"Rheumatology (Oxford)"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/rheumatology\/kel236","volume":"46","author":"Salliot C","year":"2007","unstructured":"Salliot C, Gossec L, Ruyssen-Witrand A, et al. \n                    Infections during tumour necrosis factor-alpha blocker therapy for rheumatic diseases in daily practice: a systematic retrospective study of 709 patients. \n                    Rheumatology (Oxford)  \n                    2007; \n                    46\n                    (2)\n                    : 327-4.","journal-title":"Rheumatology (Oxford)"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.autrev.2008.07.010","volume":"8","author":"Cutolo M","year":"2008","unstructured":"Cutolo M, Seriolo B, Pizzorni C, et al. \n                    Use of glucocorticoids and risk of infections. \n                    Autoimmun Rev  \n                    2008; \n                    8\n                    (2)\n                    : 153-5.","journal-title":"Autoimmun Rev"},{"key":"refR21","first-page":"69","volume":"21","author":"Momohara S","year":"2011","unstructured":"Momohara S, Kawakami K, Iwamoto T, et al. \n                    Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs. \n                    Mod Rheumatol  \n                    2011; \n                    21\n                    (5)\n                    : 69-75.","journal-title":"Mod Rheumatol"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/art.21841","volume":"55","author":"Giles JT","year":"2006","unstructured":"Giles JT, Bartlett SJ, Gelber AC, et al. \n                    Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis. \n                    Arthritis Rheum  \n                    2006; \n                    55\n                    (2)\n                    : 333-7.","journal-title":"Arthritis Rheum"},{"key":"refR23","first-page":"430","volume":"25","author":"Ruyssen-Witrand A","year":"2007","unstructured":"Ruyssen-Witrand A, Gossec L, Salliot C, et al. \n                    Complication rates of 127 surgical procedures performed in rheumatic patients receiving tumor necrosis factor alpha blockers. \n                    Clin Exp Rheumatol  \n                    2007; \n                    25\n                    (3)\n                    : 430-6.","journal-title":"Clin Exp Rheumatol"},{"key":"refR24","first-page":"689","volume":"34","author":"den Broeder AA","year":"2007","unstructured":"den Broeder AA, Creemers MC, Fransen J, et al. \n                    Risk factors for surgical site infections and other complications in elective surgery in patients with rheumatoid arthritis with special attention for anti-tumor necrosis factor: a large retrospective study. \n                    J Rheumatol  \n                    2007; \n                    34\n                    (4)\n                    : 689-95.","journal-title":"J Rheumatol"},{"key":"refR25","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1002\/art.11301","volume":"48","author":"Ellerin T","year":"2003","unstructured":"Ellerin T, Rubin RH, Weinblatt ME. \n                    Infections and anti-tumor necrosis factor alpha therapy. \n                    Arthritis Rheum  \n                    2003; \n                    48\n                    (11)\n                    : 3013-22.","journal-title":"Arthritis Rheum"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1592\/phco.2005.25.11.1566","volume":"25","author":"Busti AJ","year":"2005","unstructured":"Busti AJ, Hooper JS, Amaya CJ, et al. \n                    Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing. \n                    Pharmacotherapy  \n                    2005; \n                    25\n                    (11)\n                    : 1566-91.","journal-title":"Pharmacotherapy"},{"key":"refR27","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/art.23721","volume":"59","author":"Saag KG","year":"2008","unstructured":"Saag KG, Teng GG, Patkar NM, et al. \n                    American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. \n                    Arthritis Rheum  \n                    2008; \n                    59\n                    (6)\n                    : 762-84.","journal-title":"Arthritis Rheum"},{"key":"refR28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3899\/jrheum.120165","volume":"39","author":"Bombardier C","year":"2012","unstructured":"Bombardier C, Hazlewood GS, Akhavan P, et al. \n                    Canadian Rheumatology Association recommendations for the pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs: part II safety. \n                    J Rheumatol  \n                    2012; \n                    39\n                    (8)\n                    : 1583-602.","journal-title":"J Rheumatol"}],"container-title":["The Open Rheumatology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V7\/TORJ-7-119\/TORJ-7-119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V7\/TORJ-7-119\/TORJ-7-119.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openrheumatologyjournal.com\/contents\/volumes\/V7\/TORJ-7-119\/TORJ-7-119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T05:54:32Z","timestamp":1561096472000},"score":1,"resource":{"primary":{"URL":"https:\/\/openrheumatologyjournal.com\/VOLUME\/7\/PAGE\/119\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,11,29]]}},"alternative-id":["TORJ-7-119"],"URL":"https:\/\/doi.org\/10.2174\/1874312920131210005","relation":{},"ISSN":["1874-3129"],"issn-type":[{"value":"1874-3129","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2013-9-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-7","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}