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Four studies reported an elevated Cross-linked N-telopeptides of type I collagen (urine or serum) in patients with osteolysis or aseptic prosthetic loosening when compared to appropriate controls. Two or more studies each found elevated C-reactive protein, erythrocyte sedimentation rate, and interleukin-6 in patients with infected prosthetic joints compared to controls. Most other biomarkers were either examined by single studies or had inconsistent or insignificant associations with outcomes. We conclude that the majority of the biomarkers currently lack the evidence to be considered as biomarkers for arthroplasty outcomes. Further studies are needed.<\/jats:p>","DOI":"10.2174\/1874325001105010092","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T05:48:51Z","timestamp":1301464131000},"page":"92-105","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biomarkers in Arthroplasty: A Systematic Review"],"prefix":"10.2174","volume":"5","author":[{"given":"Marty T","family":"Mertens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasvinder A","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2106\/00004623-200704000-00012","volume":"89","author":"Kurtz S","year":"2007","unstructured":"Kurtz S, Ong K, Lau E, Mowat F, Halpern M. 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