{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T06:26:06Z","timestamp":1761287166361,"version":"build-2065373602"},"reference-count":14,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T00:00:00Z","timestamp":1226966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2008,11,18]]},"abstract":"<jats:p>To investigate the effect of brinzolamide on diurnal fluctuations in the intraocular pressure (IOP) in patients on latanoprost ophthalmic solution prospectively was aimed. Eleven patients with primary open angle glaucoma were enrolled in this study. The subjects were admitted to the hospital and had their IOPs measured over 24 hours (10 AM, noon, 2 PM, 4 PM, 6 PM, 8 PM, 10 PM, midnight, 3 AM, 6 AM, and 8AM). After topical administration of brinzolamide twice daily for 4-8 weeks for one eye, they were readmitted and again had their IOPs measured in the same manner as during the previous admission. The additional administration of brinzolamide significantly reduced IOP by 9.7\u00b14.5% during 24-hour, 9.5\u00b14.7% during daytime, and 10.3\u00b15.6% during nighttime, respectively. Brinzolamide exerts additive effects over 24 hours in reducing IOP in patients with glaucoma who are receiving latanoprost ophthalmic solution.<\/jats:p>","DOI":"10.2174\/1874364100802010160","type":"journal-article","created":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T12:35:27Z","timestamp":1227616527000},"page":"160-164","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Additive Effect of Brinzolamide on Diurnal Changes in Intraocular Pressure in Latanoprost-treated Eyes"],"prefix":"10.2174","volume":"2","author":[{"given":"Keitetsu","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1517\/14656566.8.18.3237","volume":"8","author":"Whitson JT","year":"2007","unstructured":"Whitson JT. \n                    Glaucoma a review of adjunctive therapy and new management strategies \n                    Expert Opin Pharmacother  \n                    2007; 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\n                    41\n                    : 2566-73.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"refR5","first-page":"1641","volume":"111","author":"Iwase A","year":"2004","unstructured":"Iwase A, Suzuki Y, Araie M, et al. \n                    The prevalence of primary open-angle glaucoma in Japanese: The Tajimi Study \n                    Ophthalmology  \n                    2004; \n                    111\n                    : 1641-8.","journal-title":"Ophthalmology"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0002-9394(98)00095-6","volume":"126","author":"Silver LH","year":"1998","unstructured":"Silver LH. \n                    Clinical efficacy and safety of brinzolamide (Azopt), a new topical carbonic anhydrase inhibitor for primary open-angle glaucoma and ocular hypertension.Brinzolamide Primary Therapy Study Group.  \n                    Am J Ophthalmol  \n                    1998; \n                    126\n                    : 400-8.","journal-title":"Am J Ophthalmol"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1350-9462(99)00006-3","volume":"19","author":"Sugrue MF","year":"2000","unstructured":"Sugrue MF. \n                    Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors \n                    Prog Retin Eye Res  \n                    2000; 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