{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:20:53Z","timestamp":1761895253851,"version":"build-2065373602"},"reference-count":8,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:00:00Z","timestamp":1297382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2011,2,11]]},"abstract":"<jats:p>Corneal collagen cross-linking (CxL) is a prevalent surgical method for the management of keratoconus. However, literature suggests that, further to keratoconus, CxL has a beneficial impact on a series of corneal related diseases and states.<\/jats:p>\n                  <jats:p>This article attempts to provide a contemporary review for all additional applications of CxL. Specifically, it outlines the most recent studies that demonstrate the beneficial impact of CxL for iatrogenic ectasias, pellucid marginal degeneration, infectious keratitis, bullous keratitopathy, and for ulcerative keratitis.<\/jats:p>\n                  <jats:p>The outcome of this review indicates that CxL could serve as a primary or adjuvant therapeutic modality for all aforementioned corneal-related pathologic states.<\/jats:p>","DOI":"10.2174\/1874364101105010017","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T02:06:09Z","timestamp":1302055569000},"page":"17-18","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Additional Applications of Corneal Cross Linking"],"prefix":"10.2174","volume":"5","author":[{"given":"Vassilios","family":"Kozobolis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Labiris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gkika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haris","family":"Sideroudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.jcrs.2007.07.028","volume":"33","author":"Hafezi F","year":"2007","unstructured":"Hafezi F, Kanellopoulos J, Wiltfang R, Seiler T. \n                Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after LASIK  \n                J Cataract Refract Surg  \n                2007; \n                33\n                (12 )\n                : 2035-40.","journal-title":"J Cataract Refract Surg"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jcrs.2009.03.025","volume":"35","author":"Kymionis GD","year":"2009","unstructured":"Kymionis GD, Karavitaki AE, Kounis GA, et al. \n                Management of pellucid marginal corneal degeneration with simultaneous customized photorefractive keratectomy and collagen crosslinking  \n                               J Cataract Refract Surg  \n                2009; \n                35\n                (7)\n                : 1298-301.","journal-title":"J Cataract Refract Surg"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000187630","volume":"41","author":"Wollensak G","year":"2009","unstructured":"Wollensak G, Aurich H, Wirbelauer C, Pham DT. \n                Potential use of Riboflavin\/ UVA crosslinking in bullous keratopathy  \n                Ophthalmic Res  \n                2009; \n                41\n                (2)\n                : 114-7.","journal-title":"Ophthalmic Res"},{"key":"refR4","first-page":"S730","volume":"24","author":"Krueger RR","year":"2008","unstructured":"Krueger RR, Ramos-Esteban JC, Kanellopoulos AJ. \n                Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: laboratory investigation and first clinical case \n                J Refract Surg  \n                2008; \n                24\n                (7\n                )\n                : S730-6.","journal-title":"J Refract Surg"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1167\/iovs.07-1592","volume":"49","author":"Martins SAR","year":"2008","unstructured":"Martins SAR, Combs JC, Noguera G, et al. \n                Antimicrobial efficacy of riboflavin\/UVA combination (365 n). In vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis  \n                Invest Ophthalmol Vis Sci  \n                2008; \n                49\n                : 3402-8.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/ICO.0b013e318169d698","volume":"27","author":"Iseli HP","year":"2008","unstructured":"Iseli HP, Thiel AM, Hafezi F, et al. \n                Ultraviolet A\/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts \n                Cornea  \n                2008; \n                27\n                (5)\n                : 590-4.","journal-title":"Cornea"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/112067210901900221","volume":"19","author":"Micelli Ferrari T","year":"2009","unstructured":"Micelli Ferrari T, Leozappa M, Lorusso M. \n                Escherichia coli keratitis treated with ultraviolet A\/riboflavin corneal cross-linking: a case report \n                Eur J Ophthalmol  \n                2009; \n                19\n                (2)\n                : 295-7.","journal-title":"Eur J Ophthalmol"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/ICO.0b013e3181a81802","volume":"29","author":"Kozobolis V","year":"2010","unstructured":"Kozobolis V, Labiris G, Gkika M, et al. \n                UVA collagen cross linking treatment of bullous keratopathy combined with corneal ulcer \n                Cornea  \n                2010; \n                29\n                (2 )\n                : 235-8.","journal-title":"Cornea"}],"container-title":["The Open Ophthalmology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V5\/TOOPHTJ-5-17\/TOOPHTJ-5-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V5\/TOOPHTJ-5-17\/TOOPHTJ-5-17.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V5\/TOOPHTJ-5-17\/TOOPHTJ-5-17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:42:29Z","timestamp":1761298949000},"score":1,"resource":{"primary":{"URL":"https:\/\/openophthalmologyjournal.com\/VOLUME\/5\/PAGE\/17\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,11]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2,11]]}},"alternative-id":["TOOPHTJ-5-17"],"URL":"https:\/\/doi.org\/10.2174\/1874364101105010017","relation":{},"ISSN":["1874-3641"],"issn-type":[{"type":"print","value":"1874-3641"}],"subject":[],"published":{"date-parts":[[2011,2,11]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2010-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}