{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:27:54Z","timestamp":1761298074413,"version":"build-2065373602"},"reference-count":10,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2011,12,19]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe a case of a child with a known history of pigmentary mosaicism suggestive of Hypomelanosis of Ito presenting with unilateral leukocoria, who was ultimately diagnosed with retinoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A report of a 16-month-old girl with pigmentary mosaicism and unilateral retinoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A previously healthy 16-month-old girl with a diagnosis of a mosaic hypopigmentation at the age of 6 months based on a linear and whorled pattern of skin hypopigmentation along the lines of Blaschko, presented with unilateral strabismus, leukocoria, retinal detachment, and sub-retinal exudation. Hypomelanosis of Ito and other similar neurocutaneous syndromes are known to be associated with abnormal retinal pigmentation, vascular abnormalities, and retinal detachment. Examination included a fluorescein angiogram, ultrasonography, and an MRI of the brain and orbits that demonstrated features consistent with retinoblastoma.<\/jats:p>\n                    <jats:p>Given these findings and a flat electroretinogram, the eye was enucleated with final pathologic confirmation of retinoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Previously unreported presentation of unilateral retinoblastoma in a child with pigmentary mosaicism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874364101105010055","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T04:41:06Z","timestamp":1325133666000},"page":"55-58","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Retinoblastoma Presenting in a Child with Hypomelanosis of Ito"],"prefix":"10.2174","volume":"5","author":[{"given":"Tarek","family":"El-Sawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingmin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwame","family":"Anyane-Yeboa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly D","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Folberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P","family":"Marr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","first-page":"57","volume":"55","author":"Ito M","year":"1952","unstructured":"Ito M. \n                Studies on melanin. XI. Incontinentia pigmenti achromians: a singular case of naevus depigmentosus systematicus bilateralis \n                Tohoku J Exp Med  \n                1952; \n                55\n                (Suppl\n                )\n                : 57-9.","journal-title":"Tohoku J Exp Med"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1525-1470.1992.tb00317.x","volume":"9","author":"Ruiz-Maldonado R","year":"1992","unstructured":"Ruiz-Maldonado R, Toussaint S, Tamayo L, et al. \n                Hypomelanosis of Ito: diagnostic criteria and report of 41 cases \n                Pediatr Dermatol  \n                1992; \n                9\n                (1)\n                : 1-10.","journal-title":"Pediatr Dermatol"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1017\/S0317167100027475","volume":"15","author":"Pascual-Castroviejo I","year":"1988","unstructured":"Pascual-Castroviejo I, L\u00f3pez-Rodriguez L, de la Cruz Medina M, et al. \n                Hypomelanosis of Ito. Neurological complications in 34 cases \n                Can J Neurol Sci  \n                1988; \n                15\n                (2)\n                : 124-9.","journal-title":"Can J Neurol Sci"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/(SICI)1096-8628(19990806)85:4<346::AID-AJMG7>3.0.CO;2-1","volume":"85","author":"Kuster W","year":"1999","unstructured":"Kuster W, Konig A. \n                Hypomelanosis of Ito: no entity, but a cutaneous sign of mosaicism \n                Am J Med Genet  \n                1999; \n                85\n                (4)\n                : 346-50.","journal-title":"Am J Med Genet"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1177\/088307380001501001","volume":"15","author":"Ruggieri M","year":"2000","unstructured":"Ruggieri M, Pavone L. \n                Hypomelanosis of Ito: clinical syndrome or just phenotype? \n                J Child Neurol  \n                2000; \n                15\n                (10)\n                : 635-44.","journal-title":"J Child Neurol"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1001\/archderm.1996.03890340027005","volume":"132","author":"Kishwer NS","year":"1996","unstructured":"Kishwer NS, PeBenito R, Orlow SJ. \n                Analysis of 54 Cases of Hypopigmentation and Hyperpigmentation Along the Lines of Blaschko \n                Arch Dermatol  \n                1996; \n                132\n                : 1167-70.","journal-title":"Arch Dermatol"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/jmg.25.12.809","volume":"25","author":"Donnai D","year":"1988","unstructured":"Donnai D, Read AP, McKeown C, Andrews T. \n                Hypomelanosis of Ito: a manifestation of mosaicism or chimerism \n                J Med Genet  \n                1988; \n                25\n                (12)\n                : 809-18.","journal-title":"J Med Genet"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3928\/0191-3913-19910501-11","volume":"28","author":"Weaver RG Jr","year":"1991","unstructured":"Weaver RG Jr, Martin T, Zanolli MD. \n                The ocular changes of incontinentia pigmenti achromians (hypomelanosis of Ito) \n                J Pediatr Ophthalmol Strabismus  \n                1991; \n                28\n                (3)\n                : 160-3.","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000310069","volume":"200","author":"Amon M","year":"1990","unstructured":"Amon M, Menapace R, Kirnbauer R. \n                Ocular symptomatology in familial hypomelanosis Ito. Incontinentia pigmenti achromians \n                Ophthalmologica  \n                1990; \n                200\n                (1)\n                : 1-6.","journal-title":"Ophthalmologica"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/archderm.1973.01620190068017","volume":"107","author":"Jelinek JE","year":"1973","unstructured":"Jelinek JE, Bart RS, Schiff SM. \n                Hypomelanosis of Ito (\u201cincontinentia pigmenti achromians\u201d). Report of three cases and review of the literature \n                Arch Dermatol  \n                1973; \n                107\n                (4)\n                : 596-601.","journal-title":"Arch Dermatol"}],"container-title":["The Open Ophthalmology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V5\/TOOPHTJ-5-55\/TOOPHTJ-5-55.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V5\/TOOPHTJ-5-55\/TOOPHTJ-5-55.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V5\/TOOPHTJ-5-55\/TOOPHTJ-5-55.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:23:32Z","timestamp":1761297812000},"score":1,"resource":{"primary":{"URL":"https:\/\/openophthalmologyjournal.com\/VOLUME\/5\/PAGE\/55\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,19]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12,19]]}},"alternative-id":["TOOPHTJ-5-55"],"URL":"https:\/\/doi.org\/10.2174\/1874364101105010055","relation":{},"ISSN":["1874-3641"],"issn-type":[{"type":"print","value":"1874-3641"}],"subject":[],"published":{"date-parts":[[2011,12,19]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2011-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}