{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:00:27Z","timestamp":1770354027923,"version":"3.49.0"},"reference-count":18,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2014,6,13]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p> To determine the effects of laser surgical IOP reduction by means of transscleral cyclophotocoagulation (CPC) on retinal blood flow parameters in glaucoma patients using Dynamic Vessel Analysis (DVA).\n<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Materials and Methodology: <\/jats:title>\n                    <jats:p>26 patients (average age: 70 years) with a long history of primary open angle glaucoma underwent CPC. The effect on the reactive capacity of retinal vessels was assessed before and 6-8 weeks after CPC by means of the Dynamic Vessel Analyzer (DVA) using flicker light provocation.\n<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Results: <\/jats:title>\n                    <jats:p>In our group of POAG patients, IOP was significantly reduced about approximately 20% by CPC while systemic blood pressure and heart rate were not changed.\n<\/jats:p><jats:p>The most obvious differences between the pre- and postoperative DVA measurements could be observed in the maximal dilation of the retinal arteries which increased from 0.75 % (+\/- 0.6) to 3.17 % (+\/- 0.5) with an average increase of 2.4 % (p&lt;0.01). In addition, the ability of the arteries for constriction improved significantly (p&lt;0.05) while the dynamic responses of the veins and the initial baseline values (MU) of the vessel diameters did not change.\n<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Conclusions: <\/jats:title>\n                    <jats:p>Our results of DVA measurements after an IOP-lowering laser surgical intervention (CPC) reveal a significant recovery of the regulative capacity of retinal arteries in glaucoma patients that has up to now neither been properly documented nor appreciated. Future studies with long-term follow-up must determine the clinical importance of these findings for the treatment of glaucoma patients.\n<\/jats:p>   <\/jats:sec>","DOI":"10.2174\/1874364101408010027","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T04:20:05Z","timestamp":1405916405000},"page":"27-31","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Laser Cyclophotocoagulation Enhances the Regulative Capacity of Retinal Vessels in Glaucoma"],"prefix":"10.2174","volume":"8","author":[{"given":"Stephan","family":"Kremmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Anastassiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Schallenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus-Peter","family":"Steuhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilser","family":"W","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Selbach","family":"J","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00417-006-0280-z","volume":"244","author":"Grueb M","year":"2006","unstructured":"Grueb M, Rohrbach JM,  Bartz-Schmidt KU   , et al. \n                     Transscleral diode laser cyclophotocoagulation as primary and secondary surgical treatment in primary open-angle and pseudoexfoliatve glaucoma. \n                    Long-term clinical outcomes Graefes Arch Clin Exp Ophthalmol  \n                    2006; \n                    244\n                    : 1293-9.","journal-title":"Long-term clinical outcomes. 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Ophthalmologe."},{"key":"refR7","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3109\/02713680903353764","volume":"12","author":"Nguyen TT","year":"2009","unstructured":"Nguyen TT,  Kreis AJ,  Kawasaki R  , et al. \n                     Reproducibility of the retinal vascular response to flicker light in Asians. \n                    Curr Eye Res  \n                    2009; \n                    12\n                    : 1082-8.","journal-title":"Curr Eye Res."},{"key":"refR8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1755-3768.2009.01587.x","volume":"88","author":"Garhofer G","year":"2010","unstructured":"Garhofer G, Bek T, Boehm A  , et al. \n                     Use of the retinal vessel analyzer in ocular blood flow research. \n                    Acta Ophthalmol  \n                    2010; \n                    88\n                    : 717-22.","journal-title":"Acta Ophthalmol."},{"key":"refR9","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1167\/iovs.09-5136","volume":"51","author":"Heitmar R","year":"2010","unstructured":"Heitmar R, Blann A, Cubbidge RP   , et al. \n                     Continuous retinal vessel diameter measurements - the future of retinal vessel assessment?. \n                    Invest Ophthalmol Vis Sci  \n                    2010; 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