{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:07:08Z","timestamp":1768280828281,"version":"3.49.0"},"reference-count":11,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2015,2,20]]},"abstract":"<jats:sec><jats:title>Purpose :<\/jats:title><jats:p>To report a corneal collagen cross-linking (CXL) mushroom shape demarcation line profile after limited Bowman\u2019s membrane removal by phototherapeutic keratectomy (PTK).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods :<\/jats:title><jats:p>Case report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results :<\/jats:title><jats:p>A twenty-one-year-old male with progressive keratoconus underwent mechanical epithelial debridement (at an 8.5 mm zone) followed by PTK (at a 5.0 mm zone and in a 10 \u03bcm depth) and CXL. No intra- or early postoperative complications were found. Evaluation of the corneal stromal demarcation line depth using anterior segment optical coherence tomography revealed a mushroom shape profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion :<\/jats:title><jats:p>It seems that removal of the Bowman\u2019s layer leads to greater depth of the corneal stromal demarcation line.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874364101509010017","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T10:35:39Z","timestamp":1424774139000},"page":"17-19","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Corneal Collagen Cross-Linking Mushroom Shape Demarcation Line Profile After Limited Bowman\u2019s Membrane Removal by Phototherapeutic Keratectomy"],"prefix":"10.2174","volume":"9","author":[{"given":"George D","family":"Kymionis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Grentzelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nektarios E","family":"Klados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki A","family":"Xanthopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore A","family":"Paraskevopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathios T","family":"Detorakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00055735-200108000-00008","volume":"12","author":"Rapuano CJ","year":"2001","unstructured":"Rapuano CJ. Excimer laser phototherapeutic keratectomy. Curr Opin Ophthalmol 2001; 12 : 288-93.","journal-title":"Curr Opin Ophthalmol."},{"key":"refR2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"Wollensak G","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T. Riboflavin\/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 2003; 135 : 620-7.","journal-title":"Am J Ophthalmol."},{"key":"refR3","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.ophtha.2012.03.038","volume":"119","author":"Kymionis GD","year":"2012","unstructured":"Kymionis GD, Grentzelos MA, Kounis GA, Diakonis VF, Limnopoulou AN, Panagopoulou SI. Combined transepithelial phototherapeutic keratectomy and corneal collagen cross-linking for progressive keratoconus. Ophthalmology 2012; 119 : 1777-84.","journal-title":"Ophthalmology."},{"key":"refR4","doi-asserted-by":"crossref","first-page":"146543","DOI":"10.1155\/2010\/146543","volume":"2010","author":"Kymionis GD","year":"2010","unstructured":"Kymionis GD, Grentzelos MA, Karavitaki AE, et al. Transepithelial phototherapeutic keratectomy using a 213-nm solid-state laser system followed by corneal collagen cross-linking with riboflavin and UVA irradiation. J Ophthalmol 2010; 2010 : 146543.","journal-title":"J Ophthalmol."},{"key":"refR5","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jcrs.2014.01.040","volume":"40","author":"Kymionis GD","year":"2014","unstructured":"Kymionis GD, Grentzelos MA, Kankariya VP, et al. Long-term results of combined transepithelial phototherapeutic keratectomy and corneal collagen crosslinking for keratoconus Cretan protocol. J Cataract Refract Surg 2014; 40 (9) : 1439-45.","journal-title":"J Cataract Refract Surg."},{"key":"refR6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/01.ico.0000225720.38748.58","volume":"25","author":"Seiler T","year":"2006","unstructured":"Seiler T, Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea 2006; 25 : 1057-9.","journal-title":"Cornea."},{"key":"refR7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/ICO.0b013e318030df5a","volume":"26","author":"Mazzotta C","year":"2007","unstructured":"Mazzotta C, Balestrazzi A, Traversi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced crosslinking of corneal collagen ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 2007; 26 : 390-7.","journal-title":"Cornea."},{"key":"refR8","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ajo.2009.06.031","volume":"148","author":"Doors M","year":"2009","unstructured":"Doors M, Nayyirih G, et al. Tahzib Use of anterior segment optical coherence tomography to study corneal changes after collagen cross-linking. Am J Ophthalmol 2009; 148 : 844-51.","journal-title":"Am J Ophthalmol."},{"key":"refR9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/ICO.0b013e31828733ea","volume":"32","author":"Kymionis GD","year":"2013","unstructured":"Kymionis GD, Grentzelos MA, Plaka AD, et al. Evaluation of the corneal collagen cross-linking demarcation line profile using anterior segment optical coherence tomography. Cornea 2013; 32 : 907-10.","journal-title":"Cornea."},{"key":"refR10","volume":"[Epub ahead of print]","author":"Kymionis GD","year":"2013","unstructured":"Kymionis GD, Grentzelos MA, Plaka AD, et al. Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients. Am J Ophthalmol 2013; [Epub ahead of print]","journal-title":"Am J Ophthalmol."},{"key":"refR11","first-page":"2165","volume":"43","author":"Kolozsv\u00e1ri L","year":"2002","unstructured":"Kolozsv\u00e1ri L, N\u00f3gr\u00e1di A, Hopp B, Bor Z. UV absorbance of the human cornea in the 240- to 400-nm range. Invest Ophthalmol Vis Sci 2002; 43 : 2165-8.","journal-title":"Invest Ophthalmol Vis Sci."}],"container-title":["The Open Ophthalmology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V9\/TOOPHTJ-9-17\/TOOPHTJ-9-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V9\/TOOPHTJ-9-17\/TOOPHTJ-9-17.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V9\/TOOPHTJ-9-17\/TOOPHTJ-9-17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T07:40:48Z","timestamp":1598773248000},"score":1,"resource":{"primary":{"URL":"https:\/\/openophthalmologyjournal.com\/VOLUME\/9\/PAGE\/17\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2,20]]}},"alternative-id":["TOOPHTJ-9-17"],"URL":"https:\/\/doi.org\/10.2174\/1874364101509010017","relation":{},"ISSN":["1874-3641"],"issn-type":[{"value":"1874-3641","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2,20]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2014-10-2","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-1-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-1-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-2-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}